INT94056

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.57
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Arg1) cytoplasm (Arg1)
Anatomy Link Frequency
macrophages 6
immune cells 4
spleen 2
lung 2
Peritoneal macrophages 2
Arg1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 13 98.84 Very High Very High Very High
Inflammation 96 98.68 Very High Very High Very High
cytokine 33 97.80 Very High Very High Very High
diclofenac 190 96.76 Very High Very High Very High
chemokine 9 93.24 High High
Inflammatory response 11 88.32 High High
Bioavailability 1 78.32 Quite High
agonist 1 66.24 Quite High
sodium channel 7 45.12 Quite Low
COX-2 inhibitor 12 22.00 Low Low
Disease Link Frequency Relevance Heat
Injury 46 99.98 Very High Very High Very High
Cancer 251 99.84 Very High Very High Very High
Diabetes Mellitus 29 99.56 Very High Very High Very High
Asthma 2 99.20 Very High Very High Very High
Adhesions 5 98.84 Very High Very High Very High
INFLAMMATION 112 98.68 Very High Very High Very High
Obesity 33 97.32 Very High Very High Very High
Pancreatic Cancer 26 94.32 High High
Disease 9 90.28 High High
Fibrosis 18 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Trauma induces up-regulation of arginase I gene expression in splenic immune cells within 24 h of injury.
Positive_regulation (regulation) of Gene_expression (expression) of arginase I in immune cells associated with injury
1) Confidence 0.60 Published 2001 Journal Shock Section Abstract Doc Link 11236905 Disease Relevance 0.76 Pain Relevance 0.24
Peritoneal macrophages can be involved in tumor surveillance [26] and show an enhanced arginase expression in tumor-bearing mice [27].
Positive_regulation (enhanced) of Gene_expression (expression) of arginase in Peritoneal macrophages associated with cancer
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939880 Disease Relevance 0.85 Pain Relevance 0.16
Expression of Arg1 is induced in macrophages predominantly by anti-inflammatory Th2 cytokines while iNOS is induced by inflammatory Th1 cytokines [47].
Positive_regulation (induced) of Gene_expression (Expression) of Arg1 in macrophages associated with inflammation and cytokine
3) Confidence 0.56 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.54 Pain Relevance 0.19
Trauma increased spleen arginase I protein expression and activity (P = 0.01) within 12 and for at least 48 h after injury and coincided with up-regulated arginase I mRNA abundance at 24 h.
Positive_regulation (increased) of Gene_expression (expression) of arginase I in spleen associated with injury
4) Confidence 0.41 Published 2001 Journal Shock Section Abstract Doc Link 11236905 Disease Relevance 0.73 Pain Relevance 0.25
Trauma induces up-regulation of arginase I gene expression in splenic immune cells within 24 h of injury.
Positive_regulation (induces) of Gene_expression (expression) of arginase I in immune cells associated with injury
5) Confidence 0.41 Published 2001 Journal Shock Section Abstract Doc Link 11236905 Disease Relevance 0.77 Pain Relevance 0.24
Arginase 1 (Arg1) expressed by Th2-induced fibroproliferative M2 macrophages [37] is also up-regulated during OVA-induced asthma [26], but down-regulated during post-pneumonectomy lung regeneration.
Positive_regulation (regulated) of Gene_expression (expressed) of Arginase 1 in lung associated with asthma
6) Confidence 0.34 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.87 Pain Relevance 0.28
Since macrophage arginase expression can change in response to culture dish adhesion [28] we also measured arginase activity in non-cultured freshly isolated cells from the mouse peritoneal cavity, thereby compromising on macrophages purity, (Fig 4A bottom).
Positive_regulation (change) of Gene_expression (expression) of arginase in macrophages associated with adhesions
7) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939880 Disease Relevance 0.95 Pain Relevance 0.19
The increased arginase I expression implied an increased alternative activation of macrophages in the adipose tissue, which could lead to the secretion of the anti-inflammatory cytokines IL-10 and IL-8 [47], indicating that Rx treatment may lead to polarization of resident macrophage towards the alternative state.
Positive_regulation (increased) of Gene_expression (expression) of arginase I in macrophages associated with inflammation, obesity and cytokine
8) Confidence 0.22 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.93 Pain Relevance 0.33
Assay for arginase activity
Positive_regulation (Assay) of Gene_expression (activity) of arginase
9) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2917406 Disease Relevance 0.18 Pain Relevance 0.07

General Comments

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