INT94059

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Context Info
Confidence 0.26
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.82
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (ISYNA1) cytoplasm (ISYNA1)
Anatomy Link Frequency
plasma 4
macrophages 2
skin 2
spleen 2
ISYNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Acupuncture 16 99.98 Very High Very High Very High
electroacupuncture 1 92.96 High High
anesthesia 5 92.08 High High
Pain 3 70.12 Quite High
Inflammation 29 68.12 Quite High
Neurotransmitter 1 65.92 Quite High
gABA 1 59.52 Quite High
Glutamate 1 59.16 Quite High
cytokine 7 54.72 Quite High
Inflammatory response 3 47.52 Quite Low
Disease Link Frequency Relevance Heat
Injury 77 99.84 Very High Very High Very High
Diabetes Mellitus 3 97.04 Very High Very High Very High
Infection 5 96.20 Very High Very High Very High
Alagille Syndrome 1 88.20 High High
Neuropathy 4 82.36 Quite High
Sepsis 40 78.84 Quite High
Adult Respiratory Distress Syndrome 36 78.40 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 77.56 Quite High
Lentivirus Infections 1 75.00 Quite High
Immunodeficiency 1 73.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased STAT-1 and iNOS mRNA levels were also observed in DRGs from FIV-infected animals relative to mock-infected controls.
Positive_regulation (Increased) of Transcription (levels) of iNOS
1) Confidence 0.26 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.40 Pain Relevance 0.10
Neither arginase II nor iNOS mRNA abundance in the spleen was significantly increased by trauma at 24 h.
Neg (Neither) Positive_regulation (increased) of Transcription (abundance) of iNOS in spleen associated with injury
2) Confidence 0.19 Published 2001 Journal Shock Section Abstract Doc Link 11236905 Disease Relevance 0.77 Pain Relevance 0.25
As shown in Figure 3, the expressions of iNOS and COX-2 mRNA were significantly elevated in macrophages treated with LPS (1??
Positive_regulation (elevated) of Transcription (expressions) of iNOS in macrophages
3) Confidence 0.18 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846352 Disease Relevance 0.28 Pain Relevance 0.17
Subsequent to enhanced transcription and expression of eNOS and iNOS, both total NOS activity and plasma NOS levels were increased from 12 to 24 hours after the double-hit injury.
Positive_regulation (increased) of Transcription (transcription) of iNOS in plasma associated with injury
4) Confidence 0.04 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.61 Pain Relevance 0.03
Subsequent to enhanced transcription and expression of eNOS and iNOS, both total NOS activity and plasma NOS levels were increased from 12 to 24 hours after the double-hit injury.
Positive_regulation (enhanced) of Transcription (transcription) of iNOS in plasma associated with injury
5) Confidence 0.04 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.60 Pain Relevance 0.03
Additional experiments demonstrated that acupuncture increased the level of iNOS mRNA in macrophages [44] and while examining the distributions of NO in the skin points of rats it was shown that NO contents and nNOS expression were consistently higher in the skin acupoints/meridians associated with low electric resistance [45].
Positive_regulation (increased) of Transcription (level) of iNOS in skin associated with acupuncture
6) Confidence 0.03 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1180462 Disease Relevance 0.16 Pain Relevance 0.27

General Comments

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