INT94060

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 6.70
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (ISYNA1) cytoplasm (ISYNA1)
Anatomy Link Frequency
spleen 2
plasma 1
macrophages 1
corpus 1
skin 1
ISYNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Acupuncture 16 99.70 Very High Very High Very High
aspirin 4 98.26 Very High Very High Very High
anesthesia 7 96.52 Very High Very High Very High
Sciatica 3 94.76 High High
rheumatoid arthritis 2 93.12 High High
antagonist 2 92.40 High High
electroacupuncture 1 92.40 High High
Inflammation 85 87.44 High High
agonist 1 85.80 High High
qutenza 3 84.60 Quite High
Disease Link Frequency Relevance Heat
Injury 67 98.70 Very High Very High Very High
Toxicity 21 97.48 Very High Very High Very High
Diabetes Mellitus 4 96.48 Very High Very High Very High
Infection 7 95.36 Very High Very High Very High
Nerve Root Compression 3 94.76 High High
Rheumatoid Arthritis 5 93.64 High High
Systemic Sclerosis 8 90.68 High High
INFLAMMATION 125 87.44 High High
Alagille Syndrome 1 87.36 High High
Disease 20 84.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS) and IL-1beta gene expressions were quantified by transcription of mRNA followed by real time and quantitative polymerase chain reaction.
Transcription (transcription) of iNOS
1) Confidence 0.43 Published 2002 Journal Osteoarthr. Cartil. Section Body Doc Link 12127835 Disease Relevance 0.08 Pain Relevance 0
Increased STAT-1 and iNOS mRNA levels were also observed in DRGs from FIV-infected animals relative to mock-infected controls.
Transcription (levels) of iNOS
2) Confidence 0.30 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.38 Pain Relevance 0.10
As shown in Figure 3, the expressions of iNOS and COX-2 mRNA were significantly elevated in macrophages treated with LPS (1??
Transcription (expressions) of iNOS in macrophages
3) Confidence 0.24 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846352 Disease Relevance 0.28 Pain Relevance 0.17
Although mRNA could be detected for IL-1, IL-6, iNOS and cox-2 in some of the samples, mean cycle numbers were very high and thus, have to be interpreted with caution. mRNA of iNOS and IL-6 were detected in almost all samples, while IL-1 and PGE2 were found in only very few samples.


Transcription (detected) of iNOS
4) Confidence 0.22 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC404466 Disease Relevance 0 Pain Relevance 0.03
Spleen arginase I and II and iNOS mRNA abundance, arginase I protein expression, and arginase activity were determined.
Transcription (abundance) of iNOS in Spleen
5) Confidence 0.22 Published 2001 Journal Shock Section Abstract Doc Link 11236905 Disease Relevance 0.60 Pain Relevance 0.24
Neither arginase II nor iNOS mRNA abundance in the spleen was significantly increased by trauma at 24 h.
Transcription (abundance) of iNOS in spleen associated with injury
6) Confidence 0.22 Published 2001 Journal Shock Section Abstract Doc Link 11236905 Disease Relevance 0.76 Pain Relevance 0.24
Although mRNA could be detected for IL-1, IL-6, iNOS and cox-2 in some of the samples, mean cycle numbers were very high and thus, have to be interpreted with caution. mRNA of iNOS and IL-6 were detected in almost all samples, while IL-1 and PGE2 were found in only very few samples.


Transcription (interpreted) of iNOS
7) Confidence 0.21 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC404466 Disease Relevance 0 Pain Relevance 0.03
Although mRNA could be detected for IL-1, IL-6, iNOS and cox-2 in some of the samples, mean cycle numbers were very high and thus, have to be interpreted with caution. mRNA of iNOS and IL-6 were detected in almost all samples, while IL-1 and PGE2 were found in only very few samples.


Transcription (detected) of iNOS
8) Confidence 0.21 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC404466 Disease Relevance 0 Pain Relevance 0.03
This was reflected also with the numbers of cycles for IL-1, IL-6, iNOS and cox-2, although mRNA of IL-6 and iNOS were at least detected in most of the groups.
Transcription (detected) of iNOS
9) Confidence 0.18 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC404466 Disease Relevance 0.07 Pain Relevance 0
Spermine did not affect the up-regulation of iNOS mRNA levels but in a concentration-dependent manner significantly attenuated iNOS protein levels and NO production.
Transcription (levels) of iNOS
10) Confidence 0.17 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15548540 Disease Relevance 0.29 Pain Relevance 0.04
ODC knockdown with small interfering (si) RNA resulted in increased H. pylori-stimulated iNOS protein expression and NO production without altering iNOS mRNA levels.
Transcription (levels) of iNOS
11) Confidence 0.17 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15548540 Disease Relevance 0.25 Pain Relevance 0.10
Inducible iNOS was detected in cultured PBMC by immunofluorescence, immunoblot and flow cytometry with or without IL-1 beta + TNF alpha, IL-4 or IFN gamma from day 1 to day 5.
Transcription (detected) of iNOS in PBMC
12) Confidence 0.16 Published 2001 Journal Bull. Acad. Natl. Med. Section Abstract Doc Link 11501260 Disease Relevance 1.11 Pain Relevance 0.28
the higher sensitivity of iNOS gene transcription toward
Transcription (transcription) of iNOS
13) Confidence 0.11 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1874678 Disease Relevance 0.07 Pain Relevance 0
As a multifunctional antioxidant, however, melatonin and its metabolites have unique features over the usual antioxidants including iNOS inhibition and ONOO– scavenging properties against mustard-induced acute toxicity (Sadir et al., 2007; Topal et al., 2005; Ucar et al., 2007; Yildirim et al., 2004).
Neg (inhibition) Transcription (inhibition) of iNOS associated with toxicity
14) Confidence 0.07 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 0.64 Pain Relevance 0.19
Aspirin caused gastric injury that peaked 6 h after dosing and returned to normality at 24 h. iNOS mRNA expression occurs in the corpus in parallel with damage.
Transcription (expression) of iNOS in corpus associated with aspirin and injury
15) Confidence 0.07 Published 2010 Journal FASEB J. Section Abstract Doc Link 19741170 Disease Relevance 0.24 Pain Relevance 0.14
Subsequent to enhanced transcription and expression of eNOS and iNOS, both total NOS activity and plasma NOS levels were increased from 12 to 24 hours after the double-hit injury.
Transcription (transcription) of iNOS in plasma associated with injury
16) Confidence 0.06 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.60 Pain Relevance 0.03
Additional experiments demonstrated that acupuncture increased the level of iNOS mRNA in macrophages [44] and while examining the distributions of NO in the skin points of rats it was shown that NO contents and nNOS expression were consistently higher in the skin acupoints/meridians associated with low electric resistance [45].
Transcription (level) of iNOS in skin associated with acupuncture
17) Confidence 0.04 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1180462 Disease Relevance 0.16 Pain Relevance 0.26
The mechanistic studies showed that CAPZ inhibited the expression of iNOS mRNA through the inactivation of nuclear transcription factor-kappa B (NF-kappa B).
Transcription (expression) of iNOS
18) Confidence 0.03 Published 2001 Journal Int. Immunopharmacol. Section Abstract Doc Link 11357890 Disease Relevance 0.17 Pain Relevance 0.30

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