INT9408

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Context Info
Confidence 0.69
First Reported 1981
Last Reported 2010
Negated 13
Speculated 9
Reported most in Abstract
Documents 296
Total Number 305
Disease Relevance 242.27
Pain Relevance 57.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp) extracellular region (Crp)
Anatomy Link Frequency
erythrocyte 40
white blood cell 18
blood 14
plasma 10
joint 4
Crp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 709 100.00 Very High Very High Very High
Pain 260 100.00 Very High Very High Very High
Inflammatory marker 101 100.00 Very High Very High Very High
Inflammatory response 61 100.00 Very High Very High Very High
Pain score 5 100.00 Very High Very High Very High
Inflammatory stimuli 3 100.00 Very High Very High Very High
Angina 259 99.96 Very High Very High Very High
abdominal pain 87 99.88 Very High Very High Very High
backache 31 99.86 Very High Very High Very High
methotrexate 42 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 870 100.00 Very High Very High Very High
Pain 184 100.00 Very High Very High Very High
Obesity 88 100.00 Very High Very High Very High
Adhesions 49 100.00 Very High Very High Very High
Hyperglycemia 45 100.00 Very High Very High Very High
Leukocytosis 36 100.00 Very High Very High Very High
Hyperinsulinism 13 100.00 Very High Very High Very High
Osteolysis 3 100.00 Very High Very High Very High
Cholangitis 226 99.98 Very High Very High Very High
Diabetes Mellitus 528 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
INVESTIGATIONS: Laboratory results showed marked thrombocytopenia, hyperbilirubinaemia, appreciably elevated urine retention parameters and increased C-reactive protein.
Positive_regulation (increased) of C-reactive protein in urine
1) Confidence 0.69 Published 2001 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 11595956 Disease Relevance 0.09 Pain Relevance 0
Back pain (100%), fever (75%), and elevated C-reactive protein levels (100%) were common, but gastrointestinal symptoms were not (0%).
Positive_regulation (elevated) of C-reactive protein associated with fever and backache
2) Confidence 0.68 Published 2005 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 15662331 Disease Relevance 0.85 Pain Relevance 0.15
The common presentations were low back pain with or without inflammatory reaction (fever, elevated C-reactive protein level, and mild leukocytosis).
Positive_regulation (elevated) of C-reactive protein associated with low back pain, inflammation, leukocytosis, fever and backache
3) Confidence 0.68 Published 2005 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 15805944 Disease Relevance 1.13 Pain Relevance 0.42
In a representative population of patients with unstable angina, a sizable proportion had increased serum C-reactive protein levels; however, abnormal concentrations of C-reactive protein do not predict an adverse outcome in the early phase after the acute episode.
Positive_regulation (increased) of C-reactive protein associated with angina
4) Confidence 0.68 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9352968 Disease Relevance 0.80 Pain Relevance 0.65
Moreover, it has recently been found that increased C-reactive protein is associated with a poor outcome during hospitalization in selected patients with severe unstable angina.
Positive_regulation (increased) of C-reactive protein associated with angina
5) Confidence 0.68 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9352968 Disease Relevance 0.70 Pain Relevance 0.60
A throat culture showed positive growth for group A streptococcus, and consequently antistreptolysin-O serum titer and C-reactive protein were elevated.
Positive_regulation (elevated) of C-reactive protein
6) Confidence 0.68 Published 1996 Journal Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi Section Abstract Doc Link 8854355 Disease Relevance 1.59 Pain Relevance 0.33
Laboratory investigation revealed severe leukocytosis and a sharply increased C-reactive protein level.
Positive_regulation (increased) of C-reactive protein associated with leukocytosis
7) Confidence 0.68 Published 2006 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 16463619 Disease Relevance 0.68 Pain Relevance 0.21
Both conditions are generally associated with elevation of erythrocyte sedimentation rate and C-reactive protein.
Positive_regulation (elevation) of C-reactive protein in erythrocyte
8) Confidence 0.68 Published 2006 Journal Drugs Aging Section Abstract Doc Link 16964987 Disease Relevance 1.52 Pain Relevance 0.19
Erythrocyte sedimentation rate and C-reactive protein were examined and were elevated in all 5 cases.
Positive_regulation (elevated) of C-reactive protein in Erythrocyte
9) Confidence 0.68 Published 2007 Journal J Spinal Disord Tech Section Abstract Doc Link 17538353 Disease Relevance 0.75 Pain Relevance 0.53
Group C = 22 patients with nonspecific abdominal pain, 18 (72 percent) of whom had an elevated C-reactive protein level, although in only 4 (7.1 percent) were these levels higher than 2.5 percent mg/dl.
Positive_regulation (elevated) of C-reactive protein associated with abdominal pain
10) Confidence 0.68 Published 1994 Journal Dis. Colon Rectum Section Abstract Doc Link 8287747 Disease Relevance 0.69 Pain Relevance 0.10
He had mild anemia and an elevated C-reactive protein.
Positive_regulation (elevated) of C-reactive protein associated with anaemia
11) Confidence 0.68 Published 2005 Journal Internist (Berl) Section Abstract Doc Link 15657719 Disease Relevance 0.98 Pain Relevance 0.29
As the erythrocyte sedimentation rate and C-reactive protein were increased (69/115 and 12.1 mg/dl, respectively) and abscess was diagnosed.
Positive_regulation (increased) of C-reactive protein in erythrocyte associated with abscess
12) Confidence 0.68 Published 1998 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 9762050 Disease Relevance 0.51 Pain Relevance 0.19
The grade of instability of coronary lesions as predicted by the increases in C-reactive protein induced by PTCA and/or stenting was closely correlated with Braunwald's classification of unstable angina.
Positive_regulation (increases) of C-reactive protein associated with angina
13) Confidence 0.68 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11152846 Disease Relevance 0.36 Pain Relevance 0.36
White blood cell count (P = 0.012) and plasma C-reactive protein values (P < 0.001) were significantly increased in patients suffering from deep vein thrombosis.
Positive_regulation (increased) of C-reactive protein in vein
14) Confidence 0.68 Published 2003 Journal Wien. Klin. Wochenschr. Section Body Doc Link 12674687 Disease Relevance 0.17 Pain Relevance 0
In the group as a whole, increased C-reactive protein was associated with a higher cardiovascular risk.


Positive_regulation (increased) of C-reactive protein
15) Confidence 0.68 Published 2000 Journal Eur. Heart J. Section Body Doc Link 10988012 Disease Relevance 0 Pain Relevance 0
CONCLUSION: In patients with deep vein thrombosis, thrombus formation and consequent vein wall damage induce a systemic inflammatory reaction which is reflected by significantly increased levels of white blood cells and plasma C-reactive protein.


Positive_regulation (increased) of C-reactive protein in plasma
16) Confidence 0.68 Published 2003 Journal Wien. Klin. Wochenschr. Section Body Doc Link 12674687 Disease Relevance 0.13 Pain Relevance 0
We measured baseline C-reactive protein levels before stenting with a high-sensitivity assay; 651 patients (57%) had elevated C-reactive protein levels (>5 mg/L).
Positive_regulation (elevated) of C-reactive protein
17) Confidence 0.68 Published 2003 Journal Am. J. Med. Section Body Doc Link 12829197 Disease Relevance 0.09 Pain Relevance 0
RESULTS: During the 1-year follow-up, 62 (9.5%) of the 651 patients with an elevated C-reactive protein level and 24 (4.8%) of the 501 patients with normal levels died or had a myocardial infarction (P = 0.002).
Positive_regulation (elevated) of C-reactive protein
18) Confidence 0.68 Published 2003 Journal Am. J. Med. Section Body Doc Link 12829197 Disease Relevance 0.08 Pain Relevance 0
Hypochromic anemia, hypergammaglobulinemia, and elevated C-reactive protein were found in this case.
Positive_regulation (elevated) of C-reactive protein associated with hypergammaglobulinemia and hypochromic anemia
19) Confidence 0.68 Published 2002 Journal Surg. Today Section Abstract Doc Link 12111527 Disease Relevance 0.71 Pain Relevance 0.15
In the Cox regression model, only increased C-reactive protein levels were independently related to the incidence of subsequent cardiac events (chi-square 9.8, p = 0.001).
Positive_regulation (increased) of C-reactive protein
20) Confidence 0.68 Published 1999 Journal Am. J. Cardiol. Section Abstract Doc Link 10392860 Disease Relevance 0.52 Pain Relevance 0.15

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