INT94082

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Context Info
Confidence 0.23
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 10.03
Pain Relevance 7.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IK) nucleus (IK) cell-cell signaling (IK)
Anatomy Link Frequency
T cell 6
joint 2
macrophages 2
liver 2
lymphocytes 2
IK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 921 100.00 Very High Very High Very High
Inflammation 476 100.00 Very High Very High Very High
cINOD 11 99.22 Very High Very High Very High
aspirin 11 98.92 Very High Very High Very High
Opioid 7 97.72 Very High Very High Very High
rheumatoid arthritis 71 97.66 Very High Very High Very High
fibrosis 89 97.44 Very High Very High Very High
Neuropathic pain 4 95.56 Very High Very High Very High
adenocard 9 95.04 Very High Very High Very High
Chronic pancreatitis 6 94.24 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 516 100.00 Very High Very High Very High
Wound Healing 6 100.00 Very High Very High Very High
Ulcers 10 99.84 Very High Very High Very High
Injury 26 99.68 Very High Very High Very High
Disease 123 98.64 Very High Very High Very High
Rheumatoid Arthritis 74 97.66 Very High Very High Very High
Fibrosis 85 97.44 Very High Very High Very High
Renal Disease 2 97.08 Very High Very High Very High
Nervous System Injury 4 96.48 Very High Very High Very High
Apoptosis 45 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, findings from several laboratories have demonstrated the impact of opioid treatment on antibody responses, and the molecular basis for this effect is likely due, at least in part, to the modulation of both cytokine and cytokine receptor expression.
Regulation (modulation) of Gene_expression (expression) of cytokine associated with opioid and cytokine
1) Confidence 0.23 Published 2001 Journal Drug Alcohol Depend Section Abstract Doc Link 11245967 Disease Relevance 0.23 Pain Relevance 0.77
The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.
Neg (not) Regulation (affect) of Gene_expression (expression) of cytokine in T cells associated with inflammation, cinod and cytokine
2) Confidence 0.08 Published 2001 Journal Blood Section Abstract Doc Link 11238116 Disease Relevance 0.16 Pain Relevance 0.33
Previous studies indicated that aspirin (acetylsalicylic acid [ASA]) can have profound immunomodulatory effects by regulating cytokine gene expression in several types of cells.
Regulation (regulating) of Gene_expression (expression) of cytokine associated with aspirin and cytokine
3) Confidence 0.07 Published 2001 Journal Blood Section Abstract Doc Link 11238116 Disease Relevance 0.06 Pain Relevance 0.27
Typical scenarios are decreased leukocyte numbers affecting cytokine production, liver injury that impairs synthesis of binding proteins and clearance, renal dysfunction affecting clearance, and compromise of the intestinal barrier leading to endotoxin translocation and stimulation of inflammatory mediators.
Regulation (affecting) of Gene_expression (production) of cytokine in liver associated with inflammatory mediators, renal disease, injury and cytokine
4) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 1.42 Pain Relevance 0.52
Cytokine expression and activity are highly regulated to constrain a system that has potential for immunopathology.
Regulation (regulated) of Gene_expression (expression) of Cytokine associated with cytokine
5) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.25 Pain Relevance 0.41
This report documents the findings from a pilot study involving a small number of subjects treated with Pirfenidone, a novel regulator of cytokine gene expression, administered a minimum of six months after the completion of radiation therapy.
Regulation (regulator) of Gene_expression (expression) of cytokine associated with cytokine
6) Confidence 0.01 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1891306 Disease Relevance 0.38 Pain Relevance 0.12
The goal of this pilot study is to determine if Pirfenidone, a novel regulator of cytokine gene expression, has the potential to ameliorate established radiation-induced fibrosis.


Regulation (regulator) of Gene_expression (expression) of cytokine associated with fibrosis and cytokine
7) Confidence 0.01 Published 2007 Journal Radiat Oncol Section Abstract Doc Link PMC1891306 Disease Relevance 0.57 Pain Relevance 0.34
Considering the critical role that several cytokines, such as TNF and IL-1, are thought to play in the pathogenesis of RA, the genetic variation of these cytokines and their actual presence in the joint, it is possible that polymorphisms regulating cytokine production affect the natural course of the disease [12].
Spec (possible) Regulation (regulating) of Gene_expression (production) of cytokine in joint associated with rheumatoid arthritis, disease and cytokine
8) Confidence 0.00 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 0.89 Pain Relevance 0.53
However, the effects of cAMP on signaling pathways that regulate cytokine production and cell cycle progression in Th1 and Th2 lymphocytes remain controversial.
Regulation (regulate) of Gene_expression (production) of cytokine in lymphocytes associated with cytokine
9) Confidence 0.00 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.29 Pain Relevance 0.17
When used in combination the two drugs demonstrated an additive effect on this pattern of cytokine production [15] perhaps through an effect on NFAT and AP-1 transcription factors [16].
Regulation (effect) of Gene_expression (production) of cytokine associated with cytokine
10) Confidence 0.00 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.20 Pain Relevance 0.13
In animal studies, PDE4 inhibitors inhibit antigen-mediated T cell proliferation and skew the T cell cytokine profile toward a Th2 phenotype by downregulating the expression or production of Th1 cytokines without affecting Th2 cytokine expression [58,59].
Neg (without) Regulation (affecting) of Gene_expression (expression) of cytokine in T cell associated with cytokine
11) Confidence 0.00 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.25 Pain Relevance 0.47
This fold-change of cytokine gene expression decreased at 48 h after treatment which may be due to the short half-life of cytokines in UV-inactivated infected supernatant [69,70].
Regulation (change) of Gene_expression (expression) of cytokine gene associated with cytokine
12) Confidence 0.00 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2984415 Disease Relevance 0.57 Pain Relevance 0.63
Thus, p38 MAPK is involved in regulating T cell cytokine expression in part by modulating mRNA stability, the precise molecular mechanism of which remains to be characterized.


Regulation (regulating) of Gene_expression (expression) of cytokine in T cell associated with cytokine
13) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.42 Pain Relevance 0.13
These new molecules have now helped to clarify the role of p38 MAPK in vitro and to define the mechanisms by which p38 MAPK controls for example LPS-induced cytokine expression in macrophages [19].
Regulation (controls) of Gene_expression (expression) of cytokine in macrophages associated with cytokine
14) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.05
Cytokine production is under genetic control.
Regulation (under) of Gene_expression (production) of Cytokine associated with cytokine
15) Confidence 0.00 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16428070 Disease Relevance 0.18 Pain Relevance 0.57
The transcription factor, nuclear factor-kappa B (NF-kappaB), plays a pivotal role in regulating pro-inflammatory cytokine gene expression.
Regulation (regulating) of Gene_expression (expression) of cytokine gene associated with inflammation and cytokine
16) Confidence 0.00 Published 2001 Journal Neuroreport Section Abstract Doc Link 11447311 Disease Relevance 1.06 Pain Relevance 0.86
Alterations in antral cytokine gene expression in peptic ulcer patients during ulcer healing and after Helicobacter pylori eradication.
Regulation (Alterations) of Gene_expression (expression) of cytokine gene associated with ulcers and cytokine
17) Confidence 0.00 Published 2008 Journal Scand. J. Immunol. Section Title Doc Link 18028289 Disease Relevance 0.99 Pain Relevance 0.42
SUMMARY OF BACKGROUND DATA: Transcription factor nuclear factor-kappa B is reported to play a crucial role in regulating pro-inflammatory cytokine gene expression.
Regulation (regulating) of Gene_expression (expression) of cytokine gene
18) Confidence 0.00 Published 2006 Journal Spine Section Body Doc Link 17139220 Disease Relevance 0.08 Pain Relevance 0
Effect of a wound healing electromagnetic field on inflammatory cytokine gene expression in rats.
Regulation (Effect) of Gene_expression (expression) of cytokine gene associated with inflammation, wound healing and cytokine
19) Confidence 0.00 Published 2001 Journal Biomed Sci Instrum Section Title Doc Link 11347390 Disease Relevance 1.21 Pain Relevance 0.63
Functional polymorphisms in cytokine genes have been identified that alter cytokine production.
Regulation (alter) of Gene_expression (production) of cytokine associated with cytokine
20) Confidence 0.00 Published 2004 Journal Alcohol Section Abstract Doc Link 15066699 Disease Relevance 0.81 Pain Relevance 0.58

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