INT94085

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Context Info
Confidence 0.17
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.10
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (NFASC) plasma membrane (NFASC)
Anatomy Link Frequency
T cells 1
NFASC (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 12 97.40 Very High Very High Very High
Inflammatory response 4 95.40 Very High Very High Very High
Inflammation 98 95.04 Very High Very High Very High
palliative 3 90.00 High High
Etanercept 8 87.04 High High
cytokine 24 85.52 High High
Clonidine 1 85.04 High High
cINOD 15 83.36 Quite High
rheumatoid arthritis 41 75.64 Quite High
chemokine 5 75.00 Quite High
Disease Link Frequency Relevance Heat
Skin Infection 43 100.00 Very High Very High Very High
Streptococcus Infection 1 99.44 Very High Very High Very High
Colon Cancer 15 97.32 Very High Very High Very High
INFLAMMATION 118 95.40 Very High Very High Very High
Apoptosis 4 94.36 High High
Abscess 11 93.56 High High
Opportunistic Infections 2 92.92 High High
Adhesions 82 90.72 High High
Infection 18 89.40 High High
Htlv Types I And Ii 8 88.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although meningioangiomatosis was originally described in association with NF-2, the recent study by Omeis et al [17] has been revealed that meningioangiomatosis occurred more frequently in sporadic form and only 14 cases (14%) of the 100 reported cases are associated with NF.
NF Binding (associated) of
1) Confidence 0.17 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2904739 Disease Relevance 0.60 Pain Relevance 0.03
Early diagnosis and treatment can help reduce the mortality rate associated with NF.


NF Binding (associated) of associated with skin infection
2) Confidence 0.14 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2762971 Disease Relevance 1.31 Pain Relevance 0.09
The inhibitory effect of ASA on IL-4 transcription was not mediated by decreased nuclear expression of the known salicylate target nuclear factor (NF)-kappaB and was accompanied by reduced binding of an inducible factor to an IL-4 promoter region upstream of, but not overlapping, the NF of activated T cells- and NF-kappaB-binding P1 element.
NF Neg (not) Binding (binding) of in T cells
3) Confidence 0.11 Published 2001 Journal Blood Section Abstract Doc Link 11238116 Disease Relevance 0.18 Pain Relevance 0.30
NF is most commonly associated with Group A Streptococcus infection, but other organisms have been implicated.
NF Binding (associated) of associated with streptococcus infection and skin infection
4) Confidence 0.10 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2998525 Disease Relevance 1.65 Pain Relevance 0.21
NHE inhibitors suppressed both inhibitory (I)kappaB degradation and nuclear factor (NF)-kappaB DNA binding, suggesting that a decrease in activation of the IkappaB-NF-kappaB system contributed to the suppression of HUVEC inflammatory response by NHE blockade.
NF Binding (binding) of associated with inflammatory response
5) Confidence 0.07 Published 2002 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12107048 Disease Relevance 0.46 Pain Relevance 0.35
Capsaicin treatment also induced the degradation of Tax and up-regulation of I kappa-B alpha, resulting in the decrease of nuclear factor (NF)-kappa B/p65 DNA binding activity.
NF Binding (binding) of associated with qutenza
6) Confidence 0.07 Published 2003 Journal Leuk. Res. Section Abstract Doc Link 12537981 Disease Relevance 0.58 Pain Relevance 0.44
Capsaicin treatment also induced the degradation of Tax and up-regulation of I kappa-B alpha, resulting in the decrease of nuclear factor (NF)-kappa B/p65 DNA binding activity.
NF Binding (activity) of associated with qutenza
7) Confidence 0.07 Published 2003 Journal Leuk. Res. Section Abstract Doc Link 12537981 Disease Relevance 0.58 Pain Relevance 0.44
B dimers from the NF-?
NF Binding (dimers) of
8) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779420 Disease Relevance 0.74 Pain Relevance 0.31
Therefore further direct evidence linking compounds NF161 and NF177 to their potential ability to interact with CAMs would be very useful to clarify their mechanism of action.


NF161 Binding (interact) of
9) Confidence 0.01 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.51 Pain Relevance 0.17
Therefore further direct evidence linking compounds NF161 and NF177 to their potential ability to interact with CAMs would be very useful to clarify their mechanism of action.


NF177 Binding (interact) of
10) Confidence 0.01 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.50 Pain Relevance 0.16

General Comments

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