INT94095

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 0.97
Pain Relevance 4.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (BCAT1) cytosol (BCAT1) small molecule metabolic process (BCAT1)
cellular nitrogen compound metabolic process (BCAT1) cytoplasm (BCAT1)
Anatomy Link Frequency
neurons 1
nervous system 1
BCAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 28 99.92 Very High Very High Very High
Gabapentin 39 99.84 Very High Very High Very High
anticonvulsant 4 99.68 Very High Very High Very High
GABAergic 1 88.08 High High
gABA 2 83.64 Quite High
Thalamus 1 82.28 Quite High
Pain 2 79.32 Quite High
Neuronal excitability 1 79.24 Quite High
Central nervous system 4 75.00 Quite High
Neurotransmitter 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Stress Fractures 24 99.92 Very High Very High Very High
Sprains And Strains 4 95.64 Very High Very High Very High
Convulsion 2 91.00 High High
Rickets 2 79.84 Quite High
Pain 2 79.32 Quite High
Absence Epilepsy 3 75.00 Quite High
Injury 2 71.76 Quite High
Drug Dependence 31 50.00 Quite Low
Aggression 17 5.40 Low Low
Recurrence 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of BCATc may allow BCKA to accumulate in the astroglia, thus facilitating conversion of glutamate to alpha-ketoglutarate.
Negative_regulation (Inhibition) of BCATc associated with glutamate
1) Confidence 0.49 Published 2001 Journal J. Nutr. Section Abstract Doc Link 11238772 Disease Relevance 0 Pain Relevance 0.75
Pre-steady state kinetics show that 1.3 mm gabapentin can completely inhibit the binding of leucine to reduced hBCATc, whereas 65.4 mm gabapentin is required to inhibit leucine binding to hBCATm.
Negative_regulation (reduced) of hBCATc associated with gabapentin
2) Confidence 0.38 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16141215 Disease Relevance 0 Pain Relevance 0.78
The structure of reduced hBCATc was obtained by soaking the oxidized hBCATc crystals with dithiothreitol.
Negative_regulation (reduced) of hBCATc
3) Confidence 0.38 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16141215 Disease Relevance 0 Pain Relevance 0.64
The calendar is an ongoing record of progress that the therapist can praise in BCT sessions, as well as a visual and temporal record of problems with adherence.
Negative_regulation (praise) of BCT
4) Confidence 0.37 Published 2004 Journal Sci Pract Perspect Section Body Doc Link PMC2851021 Disease Relevance 0 Pain Relevance 0
Evidence in favor of the hypothesis is: 1) The two BCAT isoenzymes appear to be localized separately in the neurons (BCATc) or in the astroglia (BCATm). 2) Inhibition of the shuttle in the direction of glutamate synthesis can be achieved by inhibiting BCATc using the neuroactive drug gabapentin.
Negative_regulation (inhibiting) of BCATc in neurons associated with glutamate and gabapentin
5) Confidence 0.32 Published 2001 Journal J. Nutr. Section Abstract Doc Link 11238772 Disease Relevance 0 Pain Relevance 0.84
The cytosolic isozyme is the predominant BCAT found in the nervous system, and only hBCATc is inhibited by gabapentin.
Negative_regulation (inhibited) of hBCATc in nervous system associated with gabapentin
6) Confidence 0.28 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16141215 Disease Relevance 0 Pain Relevance 0.76
Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin.
Negative_regulation (inhibition) of branched-chain aminotransferase associated with anticonvulsant and gabapentin
7) Confidence 0.28 Published 2005 Journal J. Biol. Chem. Section Title Doc Link 16141215 Disease Relevance 0 Pain Relevance 0.69
The addition of gabapentin, a specific inhibitor of BCAA transaminase (BCAT), reduced the transport of [1-(14)C]alpha-KIC in GAERS and NE rats to a level that became identical in both strains.
Negative_regulation (inhibitor) of BCAT associated with sprains and strains and gabapentin
8) Confidence 0.06 Published 2001 Journal J. Neurosci. Res. Section Abstract Doc Link 11746420 Disease Relevance 0.48 Pain Relevance 0.37
Overall, mean 25(OH)D levels declined during BCT (72.9 ± 30.0 vs 63.3 ± 19.8 nmol/L, P < 0.05, Figure 1A).
Negative_regulation (declined) of BCT
9) Confidence 0.04 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3017021 Disease Relevance 0 Pain Relevance 0
Decrements in nutritional status during US Army basic combat training (BCT) have been documented in female Soldiers [4].
Negative_regulation (Decrements) of BCT
10) Confidence 0.04 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3017021 Disease Relevance 0.48 Pain Relevance 0.08

General Comments

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