INT94128

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.64
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
astrocytes 3
macrophages 2
pancreas 2
microglia 1
Il18 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 2 99.68 Very High Very High Very High
Neuritis 5 99.32 Very High Very High Very High
Chronic pancreatitis 1 98.40 Very High Very High Very High
Brush evoked pain 6 97.88 Very High Very High Very High
spinal dorsal horn 2 96.48 Very High Very High Very High
Angina 2 90.72 High High
headache 1 90.72 High High
cytokine 4 79.60 Quite High
Spinal cord 4 75.00 Quite High
Neuropathic pain 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 8 99.60 Very High Very High Very High
Experimental Autoimmune Neuritis 5 99.32 Very High Very High Very High
Pancreatitis 1 98.40 Very High Very High Very High
Vasculitis 4 98.04 Very High Very High Very High
Neuropathic Pain 10 97.88 Very High Very High Very High
Disease Progression 1 97.68 Very High Very High Very High
Disease 5 92.60 High High
Death 2 91.08 High High
Cv General 3 Under Development 2 90.72 High High
Headache 1 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of IL-18 and IL-18Ralpha/beta mRNA was detectable in carotid arteries from days 2 to 14 after angioplasty.
Positive_regulation (Increased) of Gene_expression (expression) of IL-18
1) Confidence 0.50 Published 2006 Journal Circulation Section Body Doc Link 16864728 Disease Relevance 0.09 Pain Relevance 0
Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury.
Positive_regulation (Neutralization) of Gene_expression (Neutralization) of interleukin-18 associated with vasculitis
2) Confidence 0.50 Published 2006 Journal Circulation Section Title Doc Link 16864728 Disease Relevance 0.45 Pain Relevance 0.09
Immunocytochemically, both perivascular and parenchymal IL-18 protein expression was increased in the roots of EAN rats and mainly associated with ED1+ macrophages stained on serial sections.
Positive_regulation (increased) of Gene_expression (expression) of IL-18 protein in macrophages associated with neuritis
3) Confidence 0.50 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240039 Disease Relevance 1.38 Pain Relevance 0.69
In patients with active MRI lesions the levels of IL-18 in CSF and serum were significantly higher in comparison with the levels found in patients without enhancing lesions.
Positive_regulation (higher) of Gene_expression (levels) of IL-18
4) Confidence 0.40 Published 2001 Journal Acta Neurol. Scand. Section Abstract Doc Link 11551238 Disease Relevance 0.26 Pain Relevance 0.16
Nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microglia and astrocytes, respectively.
Positive_regulation (increase) of Gene_expression (expression) of IL-18 in astrocytes associated with nervous system injury and dorsal horn
5) Confidence 0.24 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.68 Pain Relevance 0.51
Nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microglia and astrocytes, respectively.
Positive_regulation (increase) of in microglia Gene_expression (expression) of IL-18 in astrocytes associated with nervous system injury and dorsal horn
6) Confidence 0.08 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.68 Pain Relevance 0.51
Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis.
Positive_regulation (Enhanced) of Gene_expression (expression) of interleukin-18 in pancreas associated with chronic pancreatitis
7) Confidence 0.05 Published 2006 Journal World J. Gastroenterol. Section Title Doc Link 17072982 Disease Relevance 0.10 Pain Relevance 0.10

General Comments

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