INT94148

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Pparg (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 5 99.08 Very High Very High Very High
agonist 2 88.32 High High
Inflammation 4 78.40 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 98.80 Very High Very High Very High
Death 2 89.20 High High
Apoptosis 3 87.60 High High
Stress 2 86.60 High High
Cancer 1 65.88 Quite High
Aging 1 52.16 Quite High
Diabetes Mellitus 2 51.00 Quite High
Obesity 3 50.60 Quite High
Increased Venous Pressure Under Development 1 49.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PPARgamma is bound and activated by fatty acid derivatives and prostaglandin J2.
Positive_regulation (activated) of PPARgamma Binding (bound) of
1) Confidence 0.43 Published 2000 Journal Br. J. Nutr. Section Abstract Doc Link 11242474 Disease Relevance 0.09 Pain Relevance 0.14
Recently, attention has been focused on the anti-proliferative activity of nonsteroidal anti-inflammatory drugs (NSAIDs) in cancerous or transformed cells, which is mediated through interaction with PPARgamma irrespective of their ability to inhibit COX-2.
Positive_regulation (mediated) of PPARgamma Binding (interaction) of associated with inflammation and cinod
2) Confidence 0.37 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 14555212 Disease Relevance 1.07 Pain Relevance 0.52

General Comments

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