INT94164

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Context Info
Confidence 0.80
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 83
Total Number 83
Disease Relevance 48.84
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
Anatomy Link Frequency
lamina 6
BxPC-3 6
Saos-2 5
HPAC 1
smooth muscle cells 1
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 584 99.42 Very High Very High Very High
qutenza 390 97.86 Very High Very High Very High
withdrawal 13 96.56 Very High Very High Very High
Opioid 169 92.40 High High
antagonist 70 91.84 High High
narcan 117 90.96 High High
Enkephalin 26 87.48 High High
agonist 95 83.12 Quite High
cINOD 54 76.64 Quite High
Inflammation 95 72.48 Quite High
Disease Link Frequency Relevance Heat
Retinoblastoma 1899 100.00 Very High Very High Very High
Cancer 1418 99.92 Very High Very High Very High
Osteogenic Sarcomas 141 99.70 Very High Very High Very High
Breast Cancer 131 99.20 Very High Very High Very High
Apoptosis 838 98.92 Very High Very High Very High
Cytomegalovirus Infection 68 98.84 Very High Very High Very High
Pancreatic Cancer 530 97.06 Very High Very High Very High
Hematologic Neoplasms 6 95.64 Very High Very High Very High
Obesity 42 95.60 Very High Very High Very High
Psoriasis 6 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This protein is known to inhibit the cyclin-dependent kinase 4 (CDK4)–mediated phosphorylation of retinoblastoma 1 protein and prevents the cell from progressing through the G1 cell cycle checkpoint (3,4).
Phosphorylation (phosphorylation) of retinoblastoma 1 associated with retinoblastoma
1) Confidence 0.80 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 1.15 Pain Relevance 0.12
Their anti-proliferative effect is mediated through increased production of cell cycle inhibitor proteins p21CIP1 [64–68, 72, 73, 77, 78] and in some instances, p27KIP1 [64, 67, 68], attenuation of cyclin D1 [73, 78] and hypophosphorylation of the retinoblastoma (Rb) protein [45].
Phosphorylation (hypophosphorylation) of retinoblastoma associated with retinoblastoma
2) Confidence 0.79 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.65 Pain Relevance 0
One of those proteins is p16INK4A, which inhibits the CDK4/6 mediated phosphorilation and inactivation of Rb (retinoblastoma) protein.
Phosphorylation (phosphorilation) of Rb associated with retinoblastoma
3) Confidence 0.79 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2556318 Disease Relevance 1.15 Pain Relevance 0
Loss in Rb function is, in most cases, a result of the phosphorylation and inactivation of Rb by the cyclin-dependent kinases (cdks), main regulators of cell cycle progression.
Phosphorylation (phosphorylation) of Rb associated with retinoblastoma
4) Confidence 0.71 Published 2001 Journal Leukemia Section Abstract Doc Link 11243375 Disease Relevance 0.86 Pain Relevance 0.03
Our observation that OGF down-regulated the phosphorylation of Rb on S795 is consistent with decreased Cdk2 kinase activity.
Phosphorylation (phosphorylation) of Rb associated with retinoblastoma
5) Confidence 0.66 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.84 Pain Relevance 0
The phosphorylation of Rb protein is necessary for cells to progress from G1 to the S phase.
Phosphorylation (phosphorylation) of Rb associated with retinoblastoma
6) Confidence 0.66 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.71 Pain Relevance 0
This would suggest that OGF action in regard to the cell cycle is not broad based, but rather extremely specific to a pathway focused on the phosphorylation of Rb.
Phosphorylation (phosphorylation) of Rb associated with retinoblastoma
7) Confidence 0.66 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.50 Pain Relevance 0.40
During the cell cycle progression, Rb is sequentially phosphorylated by different cyclin/Cdk complexes [12].
Phosphorylation (phosphorylated) of Rb associated with retinoblastoma
8) Confidence 0.66 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.88 Pain Relevance 0
We also observed that OGF had no effect on Rb S807/811 phosphorylation, which implies that OGF did not affect Cdk4 activity.
Phosphorylation (phosphorylation) of Rb associated with retinoblastoma
9) Confidence 0.66 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.82 Pain Relevance 0
OGF treatment does not change total Rb protein but decreases the amount of phosphorylated Rb
Phosphorylation (phosphorylated) of Rb associated with retinoblastoma
10) Confidence 0.66 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.70 Pain Relevance 0
Different phosphorylation sites in Rb have been demonstrated, with the preferred site being S807/811 by Cdk4/cyclin D and S795 by Cdk2/4 [12].
Phosphorylation (phosphorylation) of Rb associated with retinoblastoma
11) Confidence 0.66 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.92 Pain Relevance 0
To elucidate the role of Rb in OGF-induced BxPC-3 cell growth inhibition, Rb expression and the phosphorylated state of Rb were assessed in synchronized BxPC-3 cells.
Phosphorylation (phosphorylated) of Rb in BxPC-3 associated with retinoblastoma
12) Confidence 0.66 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.87 Pain Relevance 0
Loss in Rb function results from the phosphorylation and inactivation of Rb by the cyclin-dependent kinases (cdks), main regulators of cell cycle progression.
Phosphorylation (phosphorylation) of Rb associated with retinoblastoma
13) Confidence 0.65 Published 2000 Journal Oncogene Section Abstract Doc Link 11426645 Disease Relevance 0.76 Pain Relevance 0
In response to DNA damage, nuclear P53 accumulates and causes cell cycle arrest by inhibiting Cyclin D1 phosphorylation of the Rb gene and thereby promotes apoptosis.
Phosphorylation (phosphorylation) of Rb associated with apoptosis
14) Confidence 0.61 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 0.93 Pain Relevance 0
However, the level of phospho-Rb (Ser795), which is specifically phosphorylated by Cdk2/4 in the G1 phase [12], was decreased at 15, 18, and 21 hours following exposure to 10-6 M OGF, and reached statistical significance at 21 hours (p < 0.01) (Figs. 2A, B).
Phosphorylation (phosphorylated) of Rb associated with retinoblastoma
15) Confidence 0.57 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.87 Pain Relevance 0
Although phospho-Rb (pSer807/811) was specifically phosphorylated by Cdk4 in the G1 phase [12], OGF treatment did not alter the results of Western blot analysis of phospho-Rb (pSer807/811) levels (Fig. 2B).
Phosphorylation (phosphorylated) of Rb associated with retinoblastoma
16) Confidence 0.57 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.83 Pain Relevance 0
Using BxPC-3 cells, OGF decreased phosphorylation of retinoblastoma (Rb) protein without changing total Rb.
Phosphorylation (phosphorylation) of retinoblastoma in BxPC-3 associated with retinoblastoma
17) Confidence 0.51 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2253554 Disease Relevance 0.73 Pain Relevance 0.21
To elucidate the role of Rb in OGF-induced BxPC-3 cell growth inhibition, Rb expression and the phosphorylated state of Rb were assessed in synchronized BxPC-3 cells.
Phosphorylation (phosphorylated) of Rb in BxPC-3 associated with retinoblastoma
18) Confidence 0.51 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.82 Pain Relevance 0
Using BxPC-3 cells, OGF decreased phosphorylation of retinoblastoma (Rb) protein without changing total Rb.
Phosphorylation (phosphorylation) of Rb in BxPC-3 associated with retinoblastoma
19) Confidence 0.44 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2253554 Disease Relevance 0.73 Pain Relevance 0.21
Compared with single-agent treatment, combination treatment selectively inhibited Akt and RB1 phosphorylation.
Phosphorylation (phosphorylation) of RB1
20) Confidence 0.41 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.64 Pain Relevance 0

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