INT94165

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Context Info
Confidence 0.52
First Reported 2000
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 27.29
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
Anatomy Link Frequency
macrophages 1
HPAC 1
vulva 1
BxPC-3 1
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 28 95.80 Very High Very High Very High
withdrawal 6 91.84 High High
COX-2 inhibitor 52 90.96 High High
qutenza 130 83.92 Quite High
cINOD 23 66.64 Quite High
tolerance 7 52.24 Quite High
aspirin 4 47.00 Quite Low
Inflammation 64 44.48 Quite Low
melanocortin 1 receptor 1 33.52 Quite Low
headache 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 1066 100.00 Very High Very High Very High
Retinoblastoma 350 100.00 Very High Very High Very High
Small Cell Lung Cancer 63 99.90 Very High Very High Very High
Chondrosarcoma 37 99.52 Very High Very High Very High
Genital Human Papilloma Virus 108 99.14 Very High Very High Very High
Infection 125 99.04 Very High Very High Very High
Papillomavirus Infection 176 98.44 Very High Very High Very High
Congenital Anomalies 9 98.42 Very High Very High Very High
Basal And Squamous Cell Skin Cancer 213 97.96 Very High Very High Very High
Hematologic Neoplasms 6 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lastly, the mutated RB1 may also play a role in the observed erlotinib insensitivity, as the loss of both RB1 and PTEN as seen in this tumor has previously been implicated in gefitinib resistance [36].


Negative_regulation (loss) of RB1 associated with cancer
1) Confidence 0.52 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.77 Pain Relevance 0
Loss in Rb function is, in most cases, a result of the phosphorylation and inactivation of Rb by the cyclin-dependent kinases (cdks), main regulators of cell cycle progression.
Negative_regulation (Loss) of Rb associated with retinoblastoma
2) Confidence 0.50 Published 2001 Journal Leukemia Section Abstract Doc Link 11243375 Disease Relevance 0.69 Pain Relevance 0
In non hereditary cases (45% of all patients) both RB1 alleles are inactivated somatically in a single developing retinal progenitor cell.
Negative_regulation (inactivated) of RB1
3) Confidence 0.42 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1586012 Disease Relevance 1.39 Pain Relevance 0
One of those proteins is p16INK4A, which inhibits the CDK4/6 mediated phosphorilation and inactivation of Rb (retinoblastoma) protein.
Negative_regulation (inactivation) of Rb associated with retinoblastoma
4) Confidence 0.42 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2556318 Disease Relevance 1.14 Pain Relevance 0
We observed that in the presence of subclinical infection the lower two concentrations of progesterone treatment were not effective but at the highest concentration of progesterone, the PRA/PRB ratio was suppressed to pre-parturition levels (Figure 4).


Negative_regulation (suppressed) of PRA/PRB associated with asymptomatic infections
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.41 Pain Relevance 0.05
OGF treatment does not change total Rb protein but decreases the amount of phosphorylated Rb
Negative_regulation (decreases) of Rb associated with retinoblastoma
6) Confidence 0.35 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.70 Pain Relevance 0
To verify whether the OGF-induced downregulation of pRb was associated with changes in Cdk2, Cdk2 expression and activity levels were determined.
Spec (whether) Negative_regulation (downregulation) of pRb
7) Confidence 0.34 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.68 Pain Relevance 0
These results demonstrate that the OGF-mediated decrease of pRb was consistent with the reduction in Cdk2 kinase activities.


Negative_regulation (decrease) of pRb
8) Confidence 0.34 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.18 Pain Relevance 0
Loss in Rb function results from the phosphorylation and inactivation of Rb by the cyclin-dependent kinases (cdks), main regulators of cell cycle progression.
Negative_regulation (inactivation) of Rb associated with retinoblastoma
9) Confidence 0.34 Published 2000 Journal Oncogene Section Abstract Doc Link 11426645 Disease Relevance 0.76 Pain Relevance 0
Loss in Rb function results from the phosphorylation and inactivation of Rb by the cyclin-dependent kinases (cdks), main regulators of cell cycle progression.
Negative_regulation (Loss) of Rb associated with retinoblastoma
10) Confidence 0.34 Published 2000 Journal Oncogene Section Abstract Doc Link 11426645 Disease Relevance 0.65 Pain Relevance 0
However, the level of phospho-Rb (Ser795), which is specifically phosphorylated by Cdk2/4 in the G1 phase [12], was decreased at 15, 18, and 21 hours following exposure to 10-6 M OGF, and reached statistical significance at 21 hours (p < 0.01) (Figs. 2A, B).
Negative_regulation (decreased) of Rb associated with retinoblastoma
11) Confidence 0.30 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.87 Pain Relevance 0
In particular, TGCT has been shown to be associated with a characteristic series of abnormalities in the retinoblastoma pathway including upregulation of cyclin D2 and p27 and downregulation of RB1 and the cyclin-dependent kinase inhibitors of p16, p18, p19 and p21 [13].
Negative_regulation (downregulation) of RB1 associated with congenital anomalies, testicular cancer and retinoblastoma
12) Confidence 0.28 Published 2008 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2735737 Disease Relevance 1.37 Pain Relevance 0
LOH (loss of heterozygosity) in Rb predominantly occurs in the dedifferentiated components of dedifferentiated chondrosarcomas [23].
Negative_regulation (loss) of Rb associated with chondrosarcoma
13) Confidence 0.24 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1526734 Disease Relevance 1.69 Pain Relevance 0
Our results further demonstrated that the combinational effects of atorvastatin/celecoxib were associated with increased levels of p21(Cip1/Waf1), p27(Kip1), and phospho-JNK; decreased levels of phospho-AKT and hyper-phosphorylated Rb; and activation of caspase cascade.
Negative_regulation (decreased) of Rb
14) Confidence 0.22 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18172863 Disease Relevance 0.58 Pain Relevance 0.06
Treatment with lovastatin or celecoxib decreased the levels of cyclin D1, CDK2, pRb and E2F1, while the combination treatment showed more pronounced suppression.
Negative_regulation (decreased) of pRb
15) Confidence 0.21 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.33 Pain Relevance 0.07
For example, during HHV-5 (HCMV) infection, the UL97 CHPK is necessary and sufficient for Rb inactivation through phosphorylation on Cdk consensus sites [46].
Negative_regulation (inactivation) of Rb associated with retinoblastoma and infection
16) Confidence 0.14 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 1.34 Pain Relevance 0
Rb inactivation appears to be a critical function of UL97 for efficient viral replication [67].
Negative_regulation (inactivation) of Rb associated with retinoblastoma
17) Confidence 0.14 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 1.40 Pain Relevance 0
In spite of these limitations, there appears to be a relationship between cyclin D1 gene amplification and poor disease outcome in ER-positive patients.144–146 In contrast, cyclin D1 protein expression is associated with a good prognosis in some studies,141,147 potentially as a consequence of its positive relationship with ER expression and negative relationship with RB mutations.
Negative_regulation (relationship) of RB associated with disease
18) Confidence 0.14 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.36 Pain Relevance 0
Human retinoblastoma cells show several genetic changes in addition to Rb inactivation [16], suggesting that Rb loss provides the capacity to proliferate and that another mutation is necessary for the dividing cells to be death resistant.
Negative_regulation (loss) of Rb associated with retinoblastoma and death
19) Confidence 0.13 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3022222 Disease Relevance 1.09 Pain Relevance 0
Moreover, the inhibition of cell proliferation was correlated to a downregulation of cyclin D1, cyclin E, and pRb and the upregulation of p16 and p27 [89].
Negative_regulation (downregulation) of pRb
20) Confidence 0.11 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.03 Pain Relevance 0.10

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