INT94168

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Context Info
Confidence 0.60
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 6.60
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
Anatomy Link Frequency
BxPC-3 2
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 22 77.04 Quite High
qutenza 260 50.88 Quite High
Inflammation 36 50.08 Quite High
COX-2 inhibitor 52 48.88 Quite Low
antagonist 10 42.04 Quite Low
Kinase C inhibitor 1 28.16 Quite Low
headache 3 25.00 Low Low
Opioid 13 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
narcan 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 145 100.00 Very High Very High Very High
Cancer 341 98.20 Very High Very High Very High
Pancreatic Cancer 52 97.64 Very High Very High Very High
Hematologic Neoplasms 6 96.20 Very High Very High Very High
Death 46 90.56 High High
Disease 21 90.00 High High
Apoptosis 250 77.12 Quite High
INFLAMMATION 42 76.84 Quite High
Skin Cancer 15 75.00 Quite High
Small Cell Lung Cancer 126 69.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss in Rb function is, in most cases, a result of the phosphorylation and inactivation of Rb by the cyclin-dependent kinases (cdks), main regulators of cell cycle progression.
Positive_regulation (result) of Phosphorylation (phosphorylation) of Rb associated with retinoblastoma
1) Confidence 0.60 Published 2001 Journal Leukemia Section Abstract Doc Link 11243375 Disease Relevance 0.86 Pain Relevance 0.03
The phosphorylation of Rb protein is necessary for cells to progress from G1 to the S phase.
Positive_regulation (necessary) of Phosphorylation (phosphorylation) of Rb associated with retinoblastoma
2) Confidence 0.56 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.72 Pain Relevance 0
Loss in Rb function results from the phosphorylation and inactivation of Rb by the cyclin-dependent kinases (cdks), main regulators of cell cycle progression.
Positive_regulation (inactivation) of Phosphorylation (phosphorylation) of Rb associated with retinoblastoma
3) Confidence 0.39 Published 2000 Journal Oncogene Section Abstract Doc Link 11426645 Disease Relevance 0.76 Pain Relevance 0
Loss in Rb function results from the phosphorylation and inactivation of Rb by the cyclin-dependent kinases (cdks), main regulators of cell cycle progression.
Positive_regulation (results) of Phosphorylation (phosphorylation) of Rb associated with retinoblastoma
4) Confidence 0.39 Published 2000 Journal Oncogene Section Abstract Doc Link 11426645 Disease Relevance 0.77 Pain Relevance 0
Sulindac sulfide induced expression of p21wafl/cipl in a dose-dependent fashion, decreased cyclin D1 protein levels, and increased Rb hypophosphorylation. p21waf1/cip1 protein levels increased without a significant increase in wild-type p53, suggesting that sulindac sulfide induces a p53-independent pathway regulating p2lwafl/ciP1 protein levels in SCCHN.
Positive_regulation (increased) of Phosphorylation (hypophosphorylation) of Rb
5) Confidence 0.18 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 17172818 Disease Relevance 0.37 Pain Relevance 0.08
The hypophosphorylation of pRb proteins may depend on the inhibition of cyclin expression, however, this effect may also be
Spec (may) Positive_regulation (depend) of Phosphorylation (hypophosphorylation) of pRb
6) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.08 Pain Relevance 0
Expression of the beta- and gamma- CHPKs leads to Rb phosphorylation
Positive_regulation (leads) of Phosphorylation (phosphorylation) of Rb associated with retinoblastoma
7) Confidence 0.15 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.63 Pain Relevance 0
Phosphorylation of Rb on specific Cdk-consensus sites results in the dissociation of protein complexes between Rb, histone deacetylases (HDACs), and E2F transcription factors and allows for the expression of E2F-responsive genes that drive progression through G1 and entry into the S-phase of the cell cycle [64].
Positive_regulation (results) of Phosphorylation (Phosphorylation) of Rb associated with retinoblastoma
8) Confidence 0.15 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.90 Pain Relevance 0
For example, after DNA damage, p53, a tumor suppressor gene, activates transcription of p21, which inhibits cyclin E phosphorylation leading to hypophosphorylation of retinoblastoma protein (pRb) [81].
Positive_regulation (leading) of Phosphorylation (hypophosphorylation) of pRb associated with cancer and retinoblastoma
9) Confidence 0.13 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.29 Pain Relevance 0
The onset of mitogenic stimuli causes phosphorylation of Rb, p130 and p107 by cyclin D and E and their associated kinases.
Positive_regulation (causes) of Phosphorylation (phosphorylation) of Rb
10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.06 Pain Relevance 0
The phosphorylation of Rb, p107 and p130 results in their inactivation and dissociation from E2F proteins [25].
Positive_regulation (results) of Phosphorylation (phosphorylation) of Rb
11) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.07 Pain Relevance 0.05
These reports suggest conclusively that phosphorylation of p-Rb by Cdk2-cyclin E requires p-Rb to be hypophosphorylated, and thus, the inactivation of p-Rb involves sequential phosphorylation by cyclin D-Cdk4/6 and cyclin E/Cdk2 [26], [27].
Positive_regulation (requires) of Phosphorylation (phosphorylation) of p-Rb
12) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.20 Pain Relevance 0
These reports suggest conclusively that phosphorylation of p-Rb by Cdk2-cyclin E requires p-Rb to be hypophosphorylated, and thus, the inactivation of p-Rb involves sequential phosphorylation by cyclin D-Cdk4/6 and cyclin E/Cdk2 [26], [27].
Positive_regulation (requires) of Phosphorylation (phosphorylation) of p-Rb
13) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.20 Pain Relevance 0
Therefore we examined the anticancer activities of [6]-gingerol, and investigated its mechanism in two different pancreatic cancer cell lines, HPAC with wt p53 or BxPC-3 with mutant p53. [6]-Gingerol's antiproliferative effects are associated with changes in the expression or phosphorylation of Cyclin A, Cdks, p21 and Rb, and most commonly, causes cell cycle arrest at the G1 phase.
Positive_regulation (changes) of Phosphorylation (phosphorylation) of Rb in BxPC-3 associated with pancreatic cancer
14) Confidence 0.02 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.71 Pain Relevance 0

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