INT94169

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 8.87
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
Anatomy Link Frequency
BxPC-3 3
smooth muscle cells 2
HPAC 1
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 292 99.70 Very High Very High Very High
qutenza 130 99.16 Very High Very High Very High
withdrawal 3 87.96 High High
agonist 45 83.12 Quite High
cINOD 14 66.64 Quite High
melanocortin 1 receptor 159 61.60 Quite High
Inflammation 26 50.08 Quite High
Pain 1 44.96 Quite Low
Taxol 2 28.56 Quite Low
Kinase C inhibitor 1 28.16 Quite Low
Disease Link Frequency Relevance Heat
Retinoblastoma 36 100.00 Very High Very High Very High
Breast Cancer 79 99.20 Very High Very High Very High
Apoptosis 227 98.88 Very High Very High Very High
Hematologic Neoplasms 4 96.20 Very High Very High Very High
Cancer 394 94.68 High High
Skin Cancer 97 90.04 High High
Hyperplasia 25 86.56 High High
Melanoma 154 86.40 High High
Pancreatic Cancer 75 85.92 High High
Carcinoma In Situ 11 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This protein is known to inhibit the cyclin-dependent kinase 4 (CDK4)–mediated phosphorylation of retinoblastoma 1 protein and prevents the cell from progressing through the G1 cell cycle checkpoint (3,4).
Negative_regulation (prevents) of Phosphorylation (phosphorylation) of retinoblastoma 1 associated with retinoblastoma
1) Confidence 0.41 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 1.16 Pain Relevance 0.12
One of those proteins is p16INK4A, which inhibits the CDK4/6 mediated phosphorilation and inactivation of Rb (retinoblastoma) protein.
Negative_regulation (inhibits) of Phosphorylation (phosphorilation) of Rb associated with retinoblastoma
2) Confidence 0.41 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2556318 Disease Relevance 1.16 Pain Relevance 0
Loss in Rb function is, in most cases, a result of the phosphorylation and inactivation of Rb by the cyclin-dependent kinases (cdks), main regulators of cell cycle progression.
Negative_regulation (result) of Phosphorylation (phosphorylation) of Rb associated with retinoblastoma
3) Confidence 0.37 Published 2001 Journal Leukemia Section Abstract Doc Link 11243375 Disease Relevance 0.86 Pain Relevance 0.03
However, the level of phospho-Rb (Ser795), which is specifically phosphorylated by Cdk2/4 in the G1 phase [12], was decreased at 15, 18, and 21 hours following exposure to 10-6 M OGF, and reached statistical significance at 21 hours (p < 0.01) (Figs. 2A, B).
Negative_regulation (decreased) of Phosphorylation (phosphorylated) of Rb associated with retinoblastoma
4) Confidence 0.30 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.87 Pain Relevance 0
Compared with single-agent treatment, combination treatment selectively inhibited Akt and RB1 phosphorylation.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of RB1
5) Confidence 0.29 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.65 Pain Relevance 0
Treatment with lovastatin or celecoxib decreased the levels of cyclin D1, CDK2, pRb and E2F1, while the combination treatment showed more pronounced suppression.
Negative_regulation (decreased) of Phosphorylation (levels) of pRb
6) Confidence 0.20 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.33 Pain Relevance 0.07
In addition, frameshift mutations and stop codons lead to a truncated protein, which is not detected by antibodies and leads to negative immunohistochemistry [11, 18] After DNA damage, nuclear p53 accumulates and causes cell cycle arrest by inhibiting cyclin D1 phosphorylation of the Rb gene and thereby promoting apoptosis [9, 13].
Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of Rb associated with apoptosis
7) Confidence 0.15 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.88 Pain Relevance 0
inhibit pRb phosphorylation in vascular smooth muscle cells [106–108],
Negative_regulation (inhibit) of Phosphorylation (phosphorylation) of pRb in smooth muscle cells
8) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.46 Pain Relevance 0.07
the phosphorylation of pRb, but also decreases the amount of “free” E2F
Negative_regulation (decreases) of Phosphorylation (phosphorylation) of pRb
9) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.09 Pain Relevance 0
Our results also indicate decreased phosphorylation of Rb at Ser780 and Ser249/Thr252.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Rb
10) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.10 Pain Relevance 0
Western blotting showed that cocaine significantly decreased the phosphorylated forms of CDK2 and pRb (Figure 5A), indicating that cocaine-induced down-regulation of cyclin A results in a hypoactive state of the downstream cell cycle signaling pathway.


Negative_regulation (decreased) of Phosphorylation (phosphorylated) of pRb associated with cocaine
11) Confidence 0.06 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.18 Pain Relevance 0.42
Capsaicin-induced G1 arrest is correlated with the suppression of cyclin D1 levels, inhibition of cdk4 activity and Rb phosphorylation in endothelial and breast cancer cells [21], [22].
Negative_regulation (suppression) of Phosphorylation (phosphorylation) of Rb associated with qutenza and breast cancer
12) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 1.08 Pain Relevance 0.72
ligands can also inhibit the G1/S transition by inhibiting Rb phosphorylation [161].
Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of Rb
13) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.67 Pain Relevance 0.15
We found that the treatments decreased the phosphorylation status of Rb but did not affect total Rb (Fig. 3A).


Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Rb
14) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
Phosphorylated Rb protein was decreased in both BxPC-3 and HPAC cells by [6]-gingerol.
Negative_regulation (decreased) of Phosphorylation (Phosphorylated) of Rb in BxPC-3
15) Confidence 0.02 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.19 Pain Relevance 0
Phosphorylated Rb protein was decreased in both BxPC-3 and HPAC cells by [6]-gingerol.
Negative_regulation (decreased) of in HPAC Phosphorylation (Phosphorylated) of Rb in BxPC-3
16) Confidence 0.01 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.19 Pain Relevance 0

General Comments

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