INT94173

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.22
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSA) mitochondrion (CTSA) small molecule metabolic process (CTSA)
endoplasmic reticulum (CTSA) nucleolus (CTSA) nucleus (CTSA)
Anatomy Link Frequency
P19 1
photoreceptor 1
heart 1
CTSA (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 1 99.04 Very High Very High Very High
cva 6 89.12 High High
metalloproteinase 2 85.36 High High
bradykinin 4 69.12 Quite High
anesthesia 2 66.00 Quite High
Central nervous system 2 60.04 Quite High
Pain 2 25.56 Quite Low
Disease Link Frequency Relevance Heat
Mucopolysaccharidoses 18 99.84 Very High Very High Very High
Age-related Macular Degeneration 19 99.20 Very High Very High Very High
Corneal Disease 23 98.86 Very High Very High Very High
Hemorrhage 6 89.12 High High
Edema 6 80.88 Quite High
Rupture 4 80.00 Quite High
Lysosome Storage Disease 6 75.00 Quite High
Disease 8 72.16 Quite High
Myopia 4 67.84 Quite High
Congenital Anomalies 2 62.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Metabolic pulse-chase labeling study revealed that the GSL accumulation in suramin-treated cells may be attributed to both disturbed biosynthesis and significantly slower degradation of GSLs.
Positive_regulation (accumulation) of GSL
1) Confidence 0.53 Published 2001 Journal Mol. Genet. Metab. Section Abstract Doc Link 11243730 Disease Relevance 0.76 Pain Relevance 0.06
To further examine the possible mechanism of GSL accumulation in MPS IIID brains, we employed a cell culture model using suramin-treated neuronal cultures of differentiated P19 cells.
Spec (possible) Positive_regulation (accumulation) of GSL in P19 associated with mucopolysaccharidoses
2) Confidence 0.53 Published 2001 Journal Mol. Genet. Metab. Section Abstract Doc Link 11243730 Disease Relevance 1.03 Pain Relevance 0.10
Cathepsin, which contributes to the initiation and/or progression of keratoconus, is also responsible for photoreceptor homeostasis, and deregulation of cathepsin is associated with macular degeneration [15].
Positive_regulation (deregulation) of cathepsin in photoreceptor associated with corneal disease and age-related macular degeneration
3) Confidence 0.30 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2843708 Disease Relevance 1.43 Pain Relevance 0.09
Angiotensin 1-9 and 1-7 release in human heart: role of cathepsin A.
Positive_regulation (role) of cathepsin in heart associated with enkephalin
4) Confidence 0.10 Published 2002 Journal Hypertension Section Title Doc Link 12019279 Disease Relevance 0 Pain Relevance 0.16

General Comments

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