INT94175

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Context Info
Confidence 0.06
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.87
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (GALNT3) Golgi apparatus (GALNT3) nucleus (GALNT3)
carbohydrate metabolic process (GALNT3) cytoplasm (GALNT3)
Anatomy Link Frequency
brain 1
GALNT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 20 97.16 Very High Very High Very High
anesthesia 1 73.40 Quite High
Central nervous system 1 67.44 Quite High
Arthritis 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mucopolysaccharidoses 9 98.96 Very High Very High Very High
Aging 4 97.96 Very High Very High Very High
Pain 16 97.16 Very High Very High Very High
Death 12 96.52 Very High Very High Very High
Lysosome Storage Disease 3 75.00 Quite High
Infection 88 70.08 Quite High
Gangliosidoses 1 63.24 Quite High
Intellectual Impairment 1 59.44 Quite High
Dislocations 20 10.08 Low Low
Osteolysis 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These changes may be, in part, due to the reduction of sialidase and UDP-N-acetylgalactosamine:GM3 N-acetylgalactosaminyltransferase (GalNAc-T) activities in MPS IIID caprine brain.
Negative_regulation (reduction) of GM3 N-acetylgalactosaminyltransferase in brain associated with mucopolysaccharidoses
1) Confidence 0.06 Published 2001 Journal Mol. Genet. Metab. Section Abstract Doc Link 11243730 Disease Relevance 1.10 Pain Relevance 0.11
For this reason, we feel that the decline in HHS corresponds to a decline in general health due to aging of the patients, which has been reported in some [23] but not all [39] earlier studies.
Negative_regulation (decline) of HHS associated with aging
2) Confidence 0.04 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2837808 Disease Relevance 1.10 Pain Relevance 0.38
The observed decline in HHS from 5 years in the Charnley group and from 2 years in the Duraloc group is in accordance with what is usually seen.
Negative_regulation (decline) of HHS
3) Confidence 0.04 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2837808 Disease Relevance 0.66 Pain Relevance 0.33

General Comments

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