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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.55
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (VIPR1) plasma membrane (VIPR1) nucleus (VIPR1)
cytoplasm (VIPR1) signal transducer activity (VIPR1)
Anatomy Link Frequency
embryonic kidney 1
oocytes 1
respiratory 1
VIPR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 3 99.54 Very High Very High Very High
qutenza 18 98.48 Very High Very High Very High
agonist 9 97.24 Very High Very High Very High
Cannabinoid receptor 1 96.52 Very High Very High Very High
Central nervous system 1 95.80 Very High Very High Very High
imagery 3 91.00 High High
antagonist 13 87.04 High High
medulla 1 84.80 Quite High
Calcium channel 2 82.00 Quite High
Pain 1 81.40 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 32 87.24 High High
Pain 1 81.40 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 67.24 Quite High
Hypocapnia 4 65.92 Quite High
Alkalosis 3 64.72 Quite High
Cancer 119 50.00 Quite Low
Pressure And Volume Under Development 24 48.48 Quite Low
Acid Base Imbalance 2 45.28 Quite Low
Wound Healing 3 40.36 Quite Low
Heart Rate Under Development 13 39.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The abilities of 19 analogues of palmitoylethanolamide and two analogues of oleoylethanolamide to affect the Ca(2+) influx into human embryonic kidney cells expressing the human vanilloid receptor (hVR1-HEK293 cells) in response to anandamide (AEA) have been investigated using a FLIPR assay and a bovine serum albumin-containing assay medium.
Gene_expression (expressing) of hVR1 in embryonic kidney
1) Confidence 0.58 Published 2003 Journal Bioorg. Med. Chem. Section Abstract Doc Link 12614867 Disease Relevance 0 Pain Relevance 0
the previous orphan receptor RDC1 is now recognized as an additional CXCL12 receptor,
Gene_expression (previous) of RDC1
2) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.07 Pain Relevance 0.07
HEK-293 cells, stably expressing rVR1 or hVR1, exhibited dose-dependent increases in [Ca(++)](i) when challenged with capsaicin (EC(50)s congruent with 10 nM).
Gene_expression (expressing) of hVR1 associated with qutenza
3) Confidence 0.11 Published 2002 Journal J Biomol Screen Section Abstract Doc Link 14599363 Disease Relevance 0 Pain Relevance 0.57
Capsaicin (EC(50) = 853 nM), low pH (<5.5), and noxious heat (44 degrees C) activate hVR1 expressed in Xenopus oocytes.
Gene_expression (expressed) of hVR1 in oocytes associated with qutenza
4) Confidence 0.07 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11243859 Disease Relevance 0.08 Pain Relevance 0.79
Amplification of mtDNA Hypervariable Region I (HVR-I) diagnostic regions
Gene_expression (regions) of HVR-I
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871044 Disease Relevance 0 Pain Relevance 0
General metabolic stimulants, such as caffeine and cocoa; and respiratory stimulants, such as progesterone, increase the HVR.[11] On the other hand, respiratory depressants, such as alcohol and fragmented sleep, depress the HVR.
Gene_expression (depress) of HVR in respiratory associated with alcohol
6) Confidence 0.04 Published 2010 Journal Indian Journal of Occupational and Environmental Medicine Section Body Doc Link PMC2923424 Disease Relevance 0.40 Pain Relevance 0.09
The endogenous ligand of CB(1) cannabinoid receptors, anandamide, is also a full agonist at vanilloid VR1 receptors for capsaicin and resiniferatoxin, thereby causing an increase in cytosolic Ca(2+) concentration in human VR1-overexpressing (hVR1-HEK) cells.
Gene_expression (overexpressing) of hVR1-HEK associated with qutenza, cannabinoid receptor and agonist
7) Confidence 0.00 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278420 Disease Relevance 0 Pain Relevance 0.27

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