INT94181

Context Info Confidence 0.58 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 0.55 Pain Relevance 1.79

nucleolus (VIPR1) plasma membrane (VIPR1) nucleus (VIPR1) cytoplasm (VIPR1) signal transducer activity (VIPR1)

Anatomy Link Frequency embryonic kidney 1 oocytes 1 respiratory 1 VIPR1 (Homo sapiens)

Pain Link Frequency Relevance Heat alcohol 3 99.54 qutenza 18 98.48 agonist 9 97.24 Cannabinoid receptor 1 96.52 Central nervous system 1 95.80 imagery 3 91.00 antagonist 13 87.04 medulla 1 84.80 Calcium channel 2 82.00 Pain 1 81.40

Disease Link Frequency Relevance Heat Hypoxia 32 87.24 Pain 1 81.40 Acquired Immune Deficiency Syndrome Or Hiv Infection 6 67.24 Hypocapnia 4 65.92 Alkalosis 3 64.72 Cancer 119 50.00 Pressure And Volume Under Development 24 48.48 Acid Base Imbalance 2 45.28 Wound Healing 3 40.36 Heart Rate Under Development 13 39.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

The abilities of 19 analogues of palmitoylethanolamide and two analogues of oleoylethanolamide to affect the Ca(2+) influx into human embryonic kidney cells expressing the human vanilloid receptor (hVR1-HEK293 cells) in response to anandamide (AEA) have been investigated using a FLIPR assay and a bovine serum albumin-containing assay medium.

Gene_expression (expressing) of hVR1 in embryonic kidney

1) Confidence 0.58 Published 2003 Journal Bioorg. Med. Chem. Section Abstract Doc Link 12614867 Disease Relevance 0 Pain Relevance 0

the previous orphan receptor RDC1 is now recognized as an additional CXCL12 receptor,

Gene_expression (previous) of RDC1

2) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.07 Pain Relevance 0.07

HEK-293 cells, stably expressing rVR1 or hVR1, exhibited dose-dependent increases in [Ca(++)](i) when challenged with capsaicin (EC(50)s congruent with 10 nM).

Gene_expression (expressing) of hVR1 associated with qutenza

3) Confidence 0.11 Published 2002 Journal J Biomol Screen Section Abstract Doc Link 14599363 Disease Relevance 0 Pain Relevance 0.57

Capsaicin (EC(50) = 853 nM), low pH (<5.5), and noxious heat (44 degrees C) activate hVR1 expressed in Xenopus oocytes.

Gene_expression (expressed) of hVR1 in oocytes associated with qutenza

4) Confidence 0.07 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11243859 Disease Relevance 0.08 Pain Relevance 0.79

Amplification of mtDNA Hypervariable Region I (HVR-I) diagnostic regions

Gene_expression (regions) of HVR-I

5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871044 Disease Relevance 0 Pain Relevance 0

General metabolic stimulants, such as caffeine and cocoa; and respiratory stimulants, such as progesterone, increase the HVR.[11] On the other hand, respiratory depressants, such as alcohol and fragmented sleep, depress the HVR.

Gene_expression (depress) of HVR in respiratory associated with alcohol

6) Confidence 0.04 Published 2010 Journal Indian Journal of Occupational and Environmental Medicine Section Body Doc Link PMC2923424 Disease Relevance 0.40 Pain Relevance 0.09

The endogenous ligand of CB(1) cannabinoid receptors, anandamide, is also a full agonist at vanilloid VR1 receptors for capsaicin and resiniferatoxin, thereby causing an increase in cytosolic Ca(2+) concentration in human VR1-overexpressing (hVR1-HEK) cells.

Gene_expression (overexpressing) of hVR1-HEK associated with qutenza, cannabinoid receptor and agonist

7) Confidence 0.00 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278420 Disease Relevance 0 Pain Relevance 0.27

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