INT94189

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Context Info
Confidence 0.31
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 6.61
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (FUT3) Golgi apparatus (FUT3)
Anatomy Link Frequency
LES 3
esophagus 2
muscle 1
neurons 1
stomach 1
FUT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
nud 42 99.36 Very High Very High Very High
anesthesia 11 98.00 Very High Very High Very High
lidocaine 4 93.04 High High
Inflammation 96 85.36 High High
Serotonin 5 59.60 Quite High
Angina 15 57.56 Quite High
cytokine 29 56.24 Quite High
Inflammatory mediators 14 55.12 Quite High
medulla 44 48.72 Quite Low
Central nervous system 23 44.00 Quite Low
Disease Link Frequency Relevance Heat
Esophageal Disease 45 100.00 Very High Very High Very High
Dyspepsia 66 99.36 Very High Very High Very High
Acid Reflux 41 99.24 Very High Very High Very High
Achalasia 79 98.88 Very High Very High Very High
Gastroesophageal Reflux Disease 350 98.56 Very High Very High Very High
Pituitary Cancer 2 98.00 Very High Very High Very High
Esophageal Cancer 1 97.20 Very High Very High Very High
Thyroid Disease 1 95.12 Very High Very High Very High
Adenocarcinoma 7 87.48 High High
Cancer 5 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Multiple other techniques such as the His-Wiz infrasphincteric plicator [13], use of magnets to augment the esophageal sphincter [14], or implantation of an on-demand microstimulator into the LES to increase LES pressure [15] are under study.
Positive_regulation (increase) of LES in esophageal sphincter
1) Confidence 0.31 Published 2010 Journal Surg Endosc Section Body Doc Link PMC2869435 Disease Relevance 0.36 Pain Relevance 0.11
Distal esophageal wall and LES are innervated by postganglionic neurons, consisting of excitatory and inhibitory neurons.
Positive_regulation (innervated) of LES in neurons
2) Confidence 0.28 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2040141 Disease Relevance 1.23 Pain Relevance 0.11
A significant increase in the tone of the LES in the form of increased LES pressure also noted.
Positive_regulation (increase) of LES
3) Confidence 0.21 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.70 Pain Relevance 0.12
Table 5 illustrates that treatment with melatonin alone or combined with omeprazole (Group II & IV) leads to a significant increase in the tone of the LES in the form of increased LES pressure.
Positive_regulation (increased) of LES
4) Confidence 0.21 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.40 Pain Relevance 0.10
A significant increase in the tone of the LES in the form of increased LES pressure also noted.
Positive_regulation (increased) of LES
5) Confidence 0.21 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.68 Pain Relevance 0.11
However, the pH, 5 cm above the level of LES, was elevated from 2.3 ± 0.36, 2.1 ± 0.38 and 1.98 ± 0.37 in pretreated patients to 5.9 ± 0.65, 5.9 ± 0.48 and 6.1 ± 0.55 in patients treated with melatonin for 8 weeks, patients treated with omeprazole for 4 weeks and patients treated with melatonin and omeprazole for 4 weeks respectively).
Positive_regulation (elevated) of LES in LES
6) Confidence 0.21 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.26 Pain Relevance 0.04
Table 5 illustrates that treatment with melatonin alone or combined with omeprazole (Group II & IV) leads to a significant increase in the tone of the LES in the form of increased LES pressure.
Positive_regulation (increase) of LES
7) Confidence 0.21 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.41 Pain Relevance 0.10
Basal H2O2 levels were elevated in circular muscle of esophagitis LES, exceeding normal levels by more than 2 standard deviations.
Positive_regulation (elevated) of LES in muscle associated with esophageal disease
8) Confidence 0.12 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 1.06 Pain Relevance 0.18
Both contractile and inhibitory LES reflexes can be induced via sensory input from the pharynx, larynx, stomach, and esophagus [137].
Positive_regulation (induced) of LES in esophagus
9) Confidence 0.07 Published 2010 Journal Dysphagia Section Body Doc Link PMC2992653 Disease Relevance 0.07 Pain Relevance 0.09
Cheng et al. reported that in a cat model of hydrochloric acid reflux, hydrogen peroxide was induced by an increase of IL-1 in the LES, after which it inhibited the release of acetylcholine from cholinergic nerve terminals and caused LES relaxation by stimulating the synthesis of prostaglandin (PG) E2 and platelet-activating factor (PAF) [31, 32].
Positive_regulation (increase) of LES in LES associated with acid reflux
10) Confidence 0.04 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.91 Pain Relevance 0.10
Both contractile and inhibitory LES reflexes can be induced via sensory input from the pharynx, larynx, stomach, and esophagus [137].
Positive_regulation (induced) of LES in larynx
11) Confidence 0.02 Published 2010 Journal Dysphagia Section Body Doc Link PMC2992653 Disease Relevance 0.07 Pain Relevance 0.09
Both contractile and inhibitory LES reflexes can be induced via sensory input from the pharynx, larynx, stomach, and esophagus [137].
Positive_regulation (induced) of LES in pharynx
12) Confidence 0.02 Published 2010 Journal Dysphagia Section Body Doc Link PMC2992653 Disease Relevance 0.07 Pain Relevance 0.09
Both contractile and inhibitory LES reflexes can be induced via sensory input from the pharynx, larynx, stomach, and esophagus [137].
Positive_regulation (induced) of LES in stomach
13) Confidence 0.02 Published 2010 Journal Dysphagia Section Body Doc Link PMC2992653 Disease Relevance 0.07 Pain Relevance 0.09
Laboratory data indicated thyrotoxic state with elevated TSH, FT3 and FT4 levels.
Positive_regulation (elevated) of FT3
14) Confidence 0.00 Published 2001 Journal Masui Section Abstract Doc Link 11244780 Disease Relevance 0.34 Pain Relevance 0.17

General Comments

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