INT94193

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.29
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
response to stress (Cyp1a2)
Anatomy Link Frequency
livers 1
Cyp1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 1 92.20 High High
Nicotine 2 83.64 Quite High
tolerance 4 83.32 Quite High
Paracetamol 8 77.96 Quite High
anesthesia 1 73.48 Quite High
Glutamate 2 56.00 Quite High
chemokine 4 21.92 Low Low
Inflammation 26 10.40 Low Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 4 90.20 High High
Cancer 34 89.84 High High
Toxicity 3 89.36 High High
Acute Liver Failure 3 82.00 Quite High
Stress 2 76.68 Quite High
Injury 5 75.00 Quite High
Poisoning 2 75.00 Quite High
Acute-phase Reaction 1 71.64 Quite High
Hepatotoxicity 2 65.00 Quite High
Cirrhosis 1 47.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After the toxic dose, the mRNA levels of glutathione-S-transferase, gamma-glutamylcysteine synthetase heavy and light chain subunits, and CYP1A2 in naïve rats rose, approaching those of pretreated rats.
Transcription (levels) of CYP1A2
1) Confidence 0.65 Published 2001 Journal Pharmacol. Toxicol. Section Abstract Doc Link 11245408 Disease Relevance 0.29 Pain Relevance 0.44
Good correlations were observed between mRNA expression and enzyme activity of CYP2C11, CYP2E1, CYP3A2 and CYP1A2 in livers of rats given various doses of CCl(4).
Transcription (expression) of CYP1A2 in livers
2) Confidence 0.62 Published 2004 Journal Int J Pharm Section Abstract Doc Link 14706259 Disease Relevance 0.16 Pain Relevance 0.09
There were no significant differences in the mRNA expression of CYP1A2, 2B1 and 2E1 among any of the experimental groups.
Transcription (expression) of CYP1A2
3) Confidence 0.56 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.46 Pain Relevance 0.07
Andrographolide significantly induced the expression of CYP1A1 and CYP1A2 mRNAs in a concentration-dependent manner, and synergistically induced CYP1A1 expression with the typical CYP1A inducers [95,96].
Transcription (expression) of CYP1A2
4) Confidence 0.15 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.38 Pain Relevance 0.14

General Comments

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