INT94194

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.53
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gclc) ligase activity (Gclc)
Anatomy Link Frequency
liver 1
Gclc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 6 92.36 High High
Paracetamol 16 87.00 High High
Disease Link Frequency Relevance Heat
Necrosis 2 85.24 High High
Acute-phase Reaction 2 80.68 Quite High
Poisoning 2 75.00 Quite High
Toxicity 2 65.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After the toxic dose, the mRNA levels of glutathione-S-transferase, gamma-glutamylcysteine synthetase heavy and light chain subunits, and CYP1A2 in naïve rats rose, approaching those of pretreated rats.
Transcription (s of g) of gamma-glutamylcysteine synthetase
1) Confidence 0.58 Published 2001 Journal Pharmacol. Toxicol. Section Abstract Doc Link 11245408 Disease Relevance 0.29 Pain Relevance 0.43
Before the toxic dose pretreated rats compared to control rats had higher activity of glutathione-S-transferase (liver) and alanine aminotransferase (serum), higher hepatic mRNA level of glutathione-S-transferase and gamma-glutamylcysteine synthetase heavy and light chain subunits, and lower hepatic concentration of glutathione, cysteine and mRNA of CYP1A2 than control rats.
Transcription ( of g) of gamma-glutamylcysteine synthetase in liver
2) Confidence 0.19 Published 2001 Journal Pharmacol. Toxicol. Section Abstract Doc Link 11245408 Disease Relevance 0.24 Pain Relevance 0.44

General Comments

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