INT94196

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2011
Negated 2
Speculated 3
Reported most in Abstract
Documents 60
Total Number 65
Disease Relevance 31.64
Pain Relevance 9.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
Anatomy Link Frequency
mononuclear cells 4
epithelial cells 3
colon 2
apoptotic cell 2
platelets 2
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 65 100.00 Very High Very High Very High
bradykinin 13 100.00 Very High Very High Very High
opioid receptor 84 99.60 Very High Very High Very High
aspirin 28 99.10 Very High Very High Very High
Gabapentin 8 98.94 Very High Very High Very High
cINOD 197 97.84 Very High Very High Very High
cytokine 342 94.80 High High
Inflammation 315 94.00 High High
antagonist 171 93.80 High High
COX2 4 93.64 High High
Disease Link Frequency Relevance Heat
Apoptosis 621 99.52 Very High Very High Very High
Rheumatoid Arthritis 274 99.52 Very High Very High Very High
Infection 78 99.16 Very High Very High Very High
Colon Cancer 222 99.12 Very High Very High Very High
Cv General 2 Under Development 3 99.12 Very High Very High Very High
Death 182 98.92 Very High Very High Very High
Neuroblastoma 181 98.40 Very High Very High Very High
Cancer 493 98.32 Very High Very High Very High
Breast Cancer 60 97.50 Very High Very High Very High
INFLAMMATION 453 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the sulfide and sulfone metabolites of sulindac as well as more potent cyclic GMP-dependent phosphodiesterase inhibitors were shown to cause inhibition of extracellular signal-regulated kinase (ERK)1/2 phosphorylation at doses (40-600 microM) and times (1-5 days) consistent with the induction of apoptosis by the drugs.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of ERK associated with apoptosis
1) Confidence 0.59 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11245463 Disease Relevance 0.94 Pain Relevance 0.19
EGF-stimulated phosphorylation of ERK and Bad is blocked by pretreatment with U0126, a selective MAP kinase kinase (MKK)1/2 inhibitor.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of ERK
2) Confidence 0.57 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566304 Disease Relevance 1.32 Pain Relevance 0.16
The decreased phosphorylation of extracellular signal-regulated kinase (ERK) was induced by JEV infection and the decrease in ERK was reversed by salicylate.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of ERK associated with infection
3) Confidence 0.56 Published 2002 Journal J. Gen. Virol. Section Abstract Doc Link 12124453 Disease Relevance 0.75 Pain Relevance 0.59
Inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and induction of apoptosis by sulindac metabolites.
Negative_regulation (Inhibition) of Phosphorylation (phosphorylation) of signal-regulated kinase associated with apoptosis
4) Confidence 0.51 Published 2001 Journal Cancer Res. Section Title Doc Link 11245463 Disease Relevance 0.84 Pain Relevance 0.24
The high basal level phosphorylation of ERK was abrogated by treatment with U0126, an inhibitor for MEK1 (Fig. 5C), suggesting a constitutive activation of the MAPK pathway upstream of ERK in these metaplastic cells.
Negative_regulation (abrogated) of Phosphorylation (phosphorylation) of ERK
5) Confidence 0.46 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.45 Pain Relevance 0.03
Alternatively, as already suggested above, a reduced dephosphorylation of ERK by a deficiency in appropriate MAPK phosphatase activities could be involved.
Negative_regulation (reduced) of Phosphorylation (dephosphorylation) of ERK
6) Confidence 0.46 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.39 Pain Relevance 0.20
Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of extracellular-regulated kinase in colon associated with colon cancer
7) Confidence 0.42 Published 2003 Journal Cancer Res. Section Title Doc Link 12566304 Disease Relevance 1.43 Pain Relevance 0.17
BK treatment resulted in the phosphorylation of p38 MAPK and extracellular signal-regulated kinase (ERK)1/2, and 2-APB could suppress BK-induced phosphorylation of ERK1/2.
Negative_regulation (suppress) of Phosphorylation (phosphorylation) of ERK associated with bradykinin
8) Confidence 0.42 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15345332 Disease Relevance 0.31 Pain Relevance 0.61
Gabapentin (120 and 240 microM) also concentration-dependently inhibited collagen (1 microg mL(-1))-induced phosphoinositide breakdown, intracellular Ca(2+) mobilization, thromboxane A(2) formation, and p38 MAPK phosphorylation in human platelets.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of p38 in platelets associated with gabapentin
9) Confidence 0.41 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17883897 Disease Relevance 0.08 Pain Relevance 0.77
These results suggest that the inhibition of ERK1/2 phosphorylation is responsible for at least part of the induction of programmed cell death by sulindac metabolites.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of ERK associated with apoptosis
10) Confidence 0.41 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11245463 Disease Relevance 0.92 Pain Relevance 0.13
Aspirin and NS-398, in contrast to PD98059, did not suppress ERK1/2 phosphorylation induced by HGF.
Negative_regulation (suppress) of Phosphorylation (phosphorylation) of ERK in HGF associated with aspirin
11) Confidence 0.41 Published 2002 Journal Hepatology Section Abstract Doc Link 11981761 Disease Relevance 0.50 Pain Relevance 0.48
The decreased phosphorylation of extracellular signal-regulated kinase (ERK) was induced by JEV infection and the decrease in ERK was reversed by salicylate.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of extracellular signal-regulated kinase associated with infection
12) Confidence 0.41 Published 2002 Journal J. Gen. Virol. Section Abstract Doc Link 12124453 Disease Relevance 0.75 Pain Relevance 0.59
Both the sulfide and sulfone metabolites of sulindac as well as more potent cyclic GMP-dependent phosphodiesterase inhibitors were shown to cause inhibition of extracellular signal-regulated kinase (ERK)1/2 phosphorylation at doses (40-600 microM) and times (1-5 days) consistent with the induction of apoptosis by the drugs.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of signal-regulated kinase associated with apoptosis
13) Confidence 0.37 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11245463 Disease Relevance 0.94 Pain Relevance 0.19
Furthermore, Trolox attenuated indomethacin-induced increased phosphorylation in ERK, p38 MAPK, JNK, and AKT.
Negative_regulation (attenuated) of Phosphorylation (phosphorylation) of ERK
14) Confidence 0.37 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 0.61 Pain Relevance 0.05
Furthermore, Trolox attenuated indomethacin-induced increased phosphorylation in ERK, p38 MAPK, JNK, and AKT.
Negative_regulation (attenuated) of Phosphorylation (phosphorylation) of p38
15) Confidence 0.37 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 0.61 Pain Relevance 0.05
MEK inhibitors, PD98059 and U-0126, which inhibited ERK phosphorylation were shown to elevate 15-PGDH levels very significantly.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of ERK
16) Confidence 0.37 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.54 Pain Relevance 0.44
Alternatively, as already suggested above, a reduced dephosphorylation of ERK by a deficiency in appropriate MAPK phosphatase activities could be involved.
Negative_regulation (dephosphorylation) of Phosphorylation (dephosphorylation) of ERK
17) Confidence 0.34 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.39 Pain Relevance 0.20
Left ventricular biopsy specimens taken immediately before cross clamping from ischemic (ISCH) and from reference (REF) areas were processed to analyze p38 MAPK phosphorylation and HSP-72-protein expression.
Spec (analyze) Negative_regulation (analyze) of Spec (analyze) Phosphorylation (phosphorylation) of p38 MAPK
18) Confidence 0.34 Published 2005 Journal J Card Surg Section Body Doc Link 16153270 Disease Relevance 0 Pain Relevance 0
Left ventricular biopsy specimens taken immediately before cross clamping from ischemic (ISCH) and from reference (REF) areas were processed to analyze p38 MAPK phosphorylation and HSP-72-protein expression.
Spec (analyze) Negative_regulation (analyze) of Spec (analyze) Phosphorylation (phosphorylation) of p38 MAPK
19) Confidence 0.34 Published 2005 Journal J Card Surg Section Body Doc Link 16153270 Disease Relevance 0 Pain Relevance 0
Due to the elevated ERK phosphorylation, the response to EGF was obscured, even though a normal or even enhanced level of EGFR could be demonstrated (Fig. 5B).
Negative_regulation (obscured) of Phosphorylation (phosphorylation) of ERK
20) Confidence 0.34 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.40 Pain Relevance 0

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