INT94197

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 5.51
Pain Relevance 6.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK3) mitochondrion (MAPK3) Golgi apparatus (MAPK3)
protein complex assembly (MAPK3) protein complex (MAPK3) cytoplasm (MAPK3)
Anatomy Link Frequency
HT29 5
SH-SY5Y 2
brains 2
HEK 2
A549 1
MAPK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 6 100.00 Very High Very High Very High
fluoxetine 22 99.98 Very High Very High Very High
tetrodotoxin 1 99.84 Very High Very High Very High
Opioid 9 99.68 Very High Very High Very High
Cannabinoid 16 99.56 Very High Very High Very High
antagonist 6 99.40 Very High Very High Very High
narcan 4 98.96 Very High Very High Very High
agonist 9 98.90 Very High Very High Very High
Enkephalin 1 98.66 Very High Very High Very High
opiate 7 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 102 99.24 Very High Very High Very High
Colon Cancer 50 97.50 Very High Very High Very High
Neuroblastoma 4 96.84 Very High Very High Very High
Urological Neuroanatomy 3 95.08 Very High Very High Very High
Cancer 83 92.40 High High
Opiate Addiction 3 90.28 High High
Anaplastic Astrocytoma 2 87.08 High High
Rhabdomyosarcoma 2 86.24 High High
Medulloblastoma 2 85.56 High High
Malignant Neoplastic Disease 14 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite a complete blockade of ERK1/2 phosphorylation, U0126 did not affect opioid-induced AC superactivation, indicating that ERK1/2 activity was not required for opioid-induced AC superactivation in HEK 293 cells.
Negative_regulation (blockade) of Phosphorylation (phosphorylation) of ERK1 in HEK associated with opioid
1) Confidence 0.57 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11720767 Disease Relevance 0 Pain Relevance 0.71
Apoptosis and cell cycle arrest appeared to be independent of derivative induced inhibition of PDK1 and phosphorylation of Akt and Erk1/2.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of Erk1 associated with apoptosis
2) Confidence 0.57 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15499625 Disease Relevance 1.29 Pain Relevance 0.12
Prolonged (12h) exposure of SH-SY5Y neuroblastoma cells to the mu-opioid receptor (MOPr) agonist [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO) causes homologous desensitization as well as heterologous desensitization of the extracellular signal-regulated kinase 1/2 (ERK 1/2) phosphorylation induced by insulin-like growth factor (IGF)-I.
Negative_regulation (desensitization) of Phosphorylation (phosphorylation) of ERK 1 in SH-SY5Y associated with neuroblastoma, agonist, enkephalin and opioid receptor
3) Confidence 0.42 Published 2010 Journal FEBS Lett. Section Abstract Doc Link 20643133 Disease Relevance 0.17 Pain Relevance 0.35
Occupancy by the agonist DAMGO (Tyr-d-Ala-Gly-N-methyl-Phe-Gly-ol) resulted in phosphorylation of the ERK1/2 MAP kinases, which was blocked by the opioid antagonist naloxone but not the cannabinoid CB1 receptor inverse agonist SR141716A.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of ERK1 associated with cannabinoid, antagonist, narcan, agonist and opioid
4) Confidence 0.42 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18319252 Disease Relevance 0 Pain Relevance 0.69
Preconditioning induced phosphorylation of ERK1/2 and CREB which, along with Ca(2+) spiking and OGD tolerance, was eliminated by tetrodotoxin.
Negative_regulation (eliminated) of Phosphorylation (phosphorylation) of ERK1 associated with tetrodotoxin and tolerance
5) Confidence 0.42 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18845540 Disease Relevance 0.22 Pain Relevance 0.73
Treatment of HCT116 human colon cancer cells with the specific mitogen-activated protein kinase kinase, U0126 (5-50 microM) resulted in a time- and dose-dependent inhibition of ERK1/2 phosphorylation, and induction of apoptosis.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of ERK1 in colon associated with colon cancer and apoptosis
6) Confidence 0.41 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11245463 Disease Relevance 0.97 Pain Relevance 0.16
We demonstrate that FLX inhibits phosphorylation of ERK1/2 kinases in a time and concentration-dependent manner, followed by reduced phosphorylation of transcription factor c-Myc in A549 and HT29 cells.
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of ERK1 in HT29 associated with fluoxetine
7) Confidence 0.41 Published 2008 Journal Cancer Biol. Ther. Section Abstract Doc Link 18836303 Disease Relevance 0.84 Pain Relevance 0.93
Induction of expression of the modified cannabinoid CB1 receptor did not limit DAMGO-mediated ERK1/2 MAP kinase phosphorylation and did not allow SR141716A to enhance the function of DAMGO.
Neg (not) Negative_regulation (limit) of Phosphorylation (phosphorylation) of ERK1 associated with cannabinoid
8) Confidence 0.41 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18319252 Disease Relevance 0 Pain Relevance 0.70
We demonstrate that FLX inhibits phosphorylation of ERK1/2 kinases in a time and concentration-dependent manner, followed by reduced phosphorylation of transcription factor c-Myc in A549 and HT29 cells.
Negative_regulation (inhibits) of in A549 Phosphorylation (phosphorylation) of ERK1 in HT29 associated with fluoxetine
9) Confidence 0.14 Published 2008 Journal Cancer Biol. Ther. Section Abstract Doc Link 18836303 Disease Relevance 0.84 Pain Relevance 0.93
Separate blots were blocked overnight at 4°C in TBS with 5% BSA (Sigma) and 0.05% Tween-20 and incubated with Anti-phospho-Erk1/2 (1 ?
Negative_regulation (blocked) of Phosphorylation (phospho) of Erk1
10) Confidence 0.08 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0 Pain Relevance 0
In concordance, phosphorylation of ERK1 (p44) and ERK2 (p42) was also reduced after the treatment.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of ERK1
11) Confidence 0.08 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.40 Pain Relevance 0
We also showed that silencing of MEK1 or MEK2 expression significantly reduces the extent of ERK1 and ERK2 activating phosphorylation (Fig. 7).
Negative_regulation (reduces) of Phosphorylation (phosphorylation) of ERK1
12) Confidence 0.07 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.31 Pain Relevance 0
Notably, pronounced downregulations of phosphorylated MEK (85%) and ERK1/2 (pERK1: 81%; pERK2: 80%) were quantitated in brains of opiate addicts.
Negative_regulation (downregulations) of Phosphorylation (phosphorylated) of pERK1 in brains associated with opiate
13) Confidence 0.01 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15198681 Disease Relevance 0.47 Pain Relevance 0.87

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