INT94203

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Context Info
Confidence 0.25
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.41
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SP5, FOS) nucleoplasm (FOS) aging (FOS)
nucleolus (FOS) intracellular (SP5) DNA binding (SP5)
SP5 (Homo sapiens)
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 99.74 Very High Very High Very High
depression 2 99.08 Very High Very High Very High
headache 2 97.96 Very High Very High Very High
Migraine 6 97.20 Very High Very High Very High
Triptan 2 91.84 High High
Opioid 2 86.16 High High
gABA 2 86.00 High High
Glutamate receptor 2 85.64 High High
Neuropeptide 4 78.92 Quite High
Inflammatory response 2 77.44 Quite High
Disease Link Frequency Relevance Heat
Pain 4 99.74 Very High Very High Very High
Nociception 4 99.16 Very High Very High Very High
Depression 2 99.08 Very High Very High Very High
Increased Venous Pressure Under Development 2 98.32 Very High Very High Very High
Headache 6 97.20 Very High Very High Very High
INFLAMMATION 2 77.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All these techniques induce c-fos within Sp5C and are used as a rodent/feline model of vascular headache in humans.
Sp5C Positive_regulation (induce) of c-fos associated with headache and increased venous pressure under development
1) Confidence 0.25 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11245884 Disease Relevance 0.68 Pain Relevance 0.92
This review discusses the importance of c-fos expression within Sp5C as a marker of cephalic nociception, the different cephalic pain models that induce c-fos within Sp5C, the receptors involved and their potential role as targets for anti-migraine drugs.
Sp5C Positive_regulation (induce) of c-fos associated with nociception, pain and migraine
2) Confidence 0.25 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11245884 Disease Relevance 0.73 Pain Relevance 0.79

General Comments

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