INT94207

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Context Info
Confidence 0.22
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.24
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SP5) intracellular (SP5) DNA binding (SP5)
Anatomy Link Frequency
neuronal 1
SP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 97.56 Very High Very High Very High
Triptan 2 96.64 Very High Very High Very High
Migraine 6 95.56 Very High Very High Very High
Neuropeptide 4 95.40 Very High Very High Very High
Inflammatory response 2 93.92 High High
Opioid 2 90.96 High High
Glutamate receptor 2 90.44 High High
substance P 2 89.40 High High
Calcitonin gene-related peptide 2 88.88 High High
gABA 2 88.08 High High
Disease Link Frequency Relevance Heat
Nociception 4 99.00 Very High Very High Very High
Pain 4 97.56 Very High Very High Very High
Headache 6 95.56 Very High Very High Very High
INFLAMMATION 2 93.56 High High
Increased Venous Pressure Under Development 2 83.28 Quite High
Depression 2 79.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Orthodromic conduction along trigeminovascular fibers transmits information centrally with induction of immediate early c-fos gene within post-synaptic Sp5C neurons, as a marker of neuronal activity within central nociceptive pathways.
Positive_regulation (induction) of Sp5C in neuronal associated with nociception
1) Confidence 0.22 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11245884 Disease Relevance 0.49 Pain Relevance 0.71
This review discusses the importance of c-fos expression within Sp5C as a marker of cephalic nociception, the different cephalic pain models that induce c-fos within Sp5C, the receptors involved and their potential role as targets for anti-migraine drugs.
Positive_regulation (importance) of Sp5C associated with nociception, pain and migraine
2) Confidence 0.22 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11245884 Disease Relevance 0.75 Pain Relevance 0.90

General Comments

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