INT94207

Context Info Confidence 0.22 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.24 Pain Relevance 1.61

nucleus (SP5) intracellular (SP5) DNA binding (SP5)

Anatomy Link Frequency neuronal 1 SP5 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 4 97.56 Triptan 2 96.64 Migraine 6 95.56 Neuropeptide 4 95.40 Inflammatory response 2 93.92 Opioid 2 90.96 Glutamate receptor 2 90.44 substance P 2 89.40 Calcitonin gene-related peptide 2 88.88 gABA 2 88.08

Disease Link Frequency Relevance Heat Nociception 4 99.00 Pain 4 97.56 Headache 6 95.56 INFLAMMATION 2 93.56 Increased Venous Pressure Under Development 2 83.28 Depression 2 79.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Orthodromic conduction along trigeminovascular fibers transmits information centrally with induction of immediate early c-fos gene within post-synaptic Sp5C neurons, as a marker of neuronal activity within central nociceptive pathways.

Positive_regulation (induction) of Sp5C in neuronal associated with nociception

1) Confidence 0.22 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11245884 Disease Relevance 0.49 Pain Relevance 0.71

This review discusses the importance of c-fos expression within Sp5C as a marker of cephalic nociception, the different cephalic pain models that induce c-fos within Sp5C, the receptors involved and their potential role as targets for anti-migraine drugs.

Positive_regulation (importance) of Sp5C associated with nociception, pain and migraine

2) Confidence 0.22 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11245884 Disease Relevance 0.75 Pain Relevance 0.90

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