INT94210

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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.07
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Neurod1) nucleocytoplasmic transport (Neurod1) nucleus (Neurod1)
DNA binding (Neurod1) transcription factor binding (Neurod1) cytoplasm (Neurod1)
Anatomy Link Frequency
interpeduncular nucleus 1
Neurod1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 9 95.32 Very High Very High Very High
Kinase C 4 92.48 High High
IPN 1 91.88 High High
midbrain 1 90.40 High High
Intracerebroventricular 1 84.60 Quite High
addiction 1 38.48 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 69.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunolabeling autoradiography was used to map and quantitate the effects of beta2 and alpha4 subunit-null mutations on their putative partner subunits' protein expression. [(125)I]mAb 299 labeling was nearly eliminated in beta2(-/-) sections, although dorsal interpeduncular nucleus (IPN) retained a faint signal.
Regulation (effects) of beta2 in interpeduncular nucleus associated with ipn
1) Confidence 0.33 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.09
However, the protein levels of PKCalpha, betaI, betaII and epsilon were not affected in the same preparation.
Neg (not) Regulation (affected) of betaII
2) Confidence 0.01 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246146 Disease Relevance 0.07 Pain Relevance 0.94

General Comments

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