INT94277

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.69
Pain Relevance 4.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr2) intracellular (Egr2) DNA binding (Egr2)
ligase activity (Egr2) cytoplasm (Egr2)
Anatomy Link Frequency
lateral areas 5
sciatic nerve 2
medial 1
Egr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 25 99.98 Very High Very High Very High
withdrawal 3 99.90 Very High Very High Very High
Sciatic nerve 5 99.80 Very High Very High Very High
antagonist 1 99.22 Very High Very High Very High
Opioid 2 99.00 Very High Very High Very High
Dopamine 106 97.56 Very High Very High Very High
Hippocampus 13 97.32 Very High Very High Very High
narcan 5 97.08 Very High Very High Very High
Thalamus 27 95.60 Very High Very High Very High
Morphine 5 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 2 94.56 High High
Aids-related Complex 1 89.12 High High
Nociception 3 86.44 High High
Urological Neuroanatomy 2 78.12 Quite High
Opiate Addiction 2 69.92 Quite High
Repression 3 27.60 Quite Low
Disease 3 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Gliosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The opioid antagonist, in turn, precipitated withdrawal and increased the expression of a set of genes which are predominantly transcription factors (krox20, CREM, NGFI-B, IkappaB, etc).
Positive_regulation (increased) of Gene_expression (expression) of krox20 associated with antagonist, withdrawal and opioid
1) Confidence 0.49 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12670709 Disease Relevance 0.55 Pain Relevance 1.06
Egr2 expression was substantially more induced by METH injection in the intact side (6.1-fold) of the hemiparkinsonian rats in comparison to control animals (3.8-fold) (Table 6).
Positive_regulation (induced) of Gene_expression (expression) of Egr2
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.11
A brief, strong electrical stimulation of sciatic nerve C-fibres induced little or no expression of c-Fos or Krox-20.
Positive_regulation (induced) of Gene_expression (expression) of Krox-20 in sciatic nerve associated with c fibre and sciatic nerve
3) Confidence 0.32 Published 2001 Journal Brain Res. Section Abstract Doc Link 11251193 Disease Relevance 0.09 Pain Relevance 0.46
This simultaneous stimulation was the only type of stimulation to induce expression of Krox-20.
Positive_regulation (induce) of Gene_expression (expression) of Krox-20
4) Confidence 0.32 Published 2001 Journal Brain Res. Section Abstract Doc Link 11251193 Disease Relevance 0.05 Pain Relevance 0.52
A weak C-fiber input caused by noxious mechanical stimulation of the skin of one hindpaw did not induce expression of c-Fos, FosB, Krox-20 or Krox-24; but it did reduce the basal expressions of c-Jun and JunD in both the medial and lateral areas.
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of Krox-20 in lateral areas associated with c fibre
5) Confidence 0.23 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.74
An intense input produced by electrical stimulation of all the C-fibers in one sciatic nerve also failed to induce expression of c-Fos, FosB, Krox-20 or Krox-24 in the medial or lateral areas.
Neg (failed) Positive_regulation (induce) of Gene_expression (expression) of Krox-20 in lateral areas associated with c fibre and sciatic nerve
6) Confidence 0.23 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.78
A weak C-fiber input caused by noxious mechanical stimulation of the skin of one hindpaw did not induce expression of c-Fos, FosB, Krox-20 or Krox-24; but it did reduce the basal expressions of c-Jun and JunD in both the medial and lateral areas.
Neg (not) Positive_regulation (induce) of in medial Gene_expression (expression) of Krox-20 in lateral areas associated with c fibre
7) Confidence 0.08 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.74

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