INT94285

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.61
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (CD36) transport (CD36) small molecule metabolic process (CD36)
cell adhesion (CD36) Golgi apparatus (CD36) plasma membrane (CD36)
Anatomy Link Frequency
monocyte 2
macrophages 1
fat 1
plaque 1
lung 1
CD36 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 4 99.54 Very High Very High Very High
Angina 6 97.92 Very High Very High Very High
cytokine 36 96.72 Very High Very High Very High
Analgesic 4 96.20 Very High Very High Very High
rheumatoid arthritis 126 94.40 High High
Inflammation 95 93.36 High High
depression 3 92.16 High High
aspirin 6 86.48 High High
Adalimumab 146 84.08 Quite High
anesthesia 7 78.72 Quite High
Disease Link Frequency Relevance Heat
Adhesions 14 100.00 Very High Very High Very High
Stress 6 100.00 Very High Very High Very High
Hypersensitivity 2 100.00 Very High Very High Very High
Pulmonary Alveolar Proteinosis 8 99.84 Very High Very High Very High
Hypertension 2 99.84 Very High Very High Very High
Targeted Disruption 4 99.72 Very High Very High Very High
Increased Venous Pressure Under Development 24 99.44 Very High Very High Very High
Metabolic Syndrome 6 99.32 Very High Very High Very High
Atherosclerotic Plaque 5 98.96 Very High Very High Very High
Cv General 3 Under Development 5 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myocardial iodine-123 beta-methyl-p-iodophenyl-pentadecanoic acid uptake was absent, but thallium-201 uptake during single photon emission computed tomography was normal, and neither platelet nor monocyte expression of the CD36 molecule was observed, indicating type I CD36 deficiency.
Negative_regulation (deficiency) of CD36 in monocyte
1) Confidence 0.43 Published 2006 Journal J Cardiol Section Abstract Doc Link 16886497 Disease Relevance 0.66 Pain Relevance 0.27
Type I CD36 deficiency associated with metabolic syndrome and vasospastic angina: a case report.
Negative_regulation (deficiency) of CD36 associated with angina and metabolic syndrome
2) Confidence 0.43 Published 2006 Journal J Cardiol Section Title Doc Link 16886497 Disease Relevance 0.69 Pain Relevance 0.30
The accumulation of oxidized LDLs by macrophages from subjects naturally deficient in CD36 appears clearly reduced [17].
Negative_regulation (deficient) of CD36 in macrophages
3) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.94 Pain Relevance 0.27
In humans, subjects naturally deficient in CD36 show greater atherosclerosis, which suggests CD36 has an anti-atherogenic role [49].
Negative_regulation (deficient) of CD36 associated with increased venous pressure under development
4) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.98 Pain Relevance 0.38
Other system issues such as the dynamic profile of high-dose lidocaine pharmacokinetics, the deportation of fat globules in the bloodstream, and the incidence of intraoperative hypothermia remain as unresolved topics for interdisciplinary, multi-institutional clinical research.
Negative_regulation (deportation) of fat in fat associated with hypothermia and lidocaine
5) Confidence 0.41 Published 2001 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 11252101 Disease Relevance 0.79 Pain Relevance 0.57
The CD36 glycoprotein, which plays a role in cellular adhesion and in the regulation of fatty acid transport and uptake, and participates in cellular control of oxidative stress by binding to oxidized low-density lipoprotein [15], was downregulated after 1-h exposure, but was upregulated after 6 h exposure to L. plantarum.
Negative_regulation (downregulated) of CD36 associated with stress and adhesions
6) Confidence 0.24 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.38 Pain Relevance 0
Inhibition of MSR-A and CD36 has been shown to reduce atherosclerotic plaque size [35] and foam-cell formation [36].
Negative_regulation (Inhibition) of CD36 in plaque associated with atherosclerotic plaque
7) Confidence 0.16 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.60 Pain Relevance 0.03
and CD36 deficiency in PAP was cell type-specific in the lung (i.e. found in AM and not in bronchial epithelial cells).
Negative_regulation (deficiency) of CD36 in lung associated with pulmonary alveolar proteinosis
8) Confidence 0.16 Published 2005 Journal Respir Res Section Body Doc Link PMC1242255 Disease Relevance 0.95 Pain Relevance 0.06
That FA oxidation during reperfusion can be protective is also supported by studies showing decreased functional recovery of hearts from fatty acid transporter-knockout animals that lack the sarcolemmal fatty acid transporter CD36 [65], a similar observation as found for GLUT4-knockout animals [66].
Negative_regulation (lack) of CD36 in hearts associated with targeted disruption
9) Confidence 0.09 Published 2008 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2329728 Disease Relevance 0.41 Pain Relevance 0.04
Monocyte populations were gated using FSC/SSC and anti-CD14PE, and CD36 MFI determined using a BD FACS Canto Flow Cytometer.
Negative_regulation (using) of CD36 in Monocyte associated with hypersensitivity
10) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.19 Pain Relevance 0.05

General Comments

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