INT943

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2010
Negated 12
Speculated 6
Reported most in Abstract
Documents 205
Total Number 211
Disease Relevance 38.42
Pain Relevance 174.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
spinal 10
plasma 7
spinal cord 6
cerebral cortex 6
brain 4
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 1287 100.00 Very High Very High Very High
antagonist 207 100.00 Very High Very High Very High
Morphine 181 100.00 Very High Very High Very High
Opioid 144 100.00 Very High Very High Very High
Enkephalin 103 100.00 Very High Very High Very High
substance P 93 100.00 Very High Very High Very High
Somatostatin 79 100.00 Very High Very High Very High
tolerance 77 100.00 Very High Very High Very High
Spinal cord 68 100.00 Very High Very High Very High
narcan 59 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 19 100.00 Very High Very High Very High
Contracture 5 100.00 Very High Very High Very High
Epilepsy 12 99.92 Very High Very High Very High
Aging 8 99.88 Very High Very High Very High
Frailty 2 99.88 Very High Very High Very High
Obesity 13 99.84 Very High Very High Very High
Pain 92 99.70 Very High Very High Very High
INFLAMMATION 58 99.70 Very High Very High Very High
Pancreatitis 69 99.66 Very High Very High Very High
Urological Neuroanatomy 43 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the locomotor and ingestive effects of CCK are abolished by subdiaphragmatic vagotomy.
Negative_regulation (abolished) of CCK associated with cholecystokinin
1) Confidence 0.59 Published 1986 Journal Peptides Section Abstract Doc Link 3763436 Disease Relevance 0 Pain Relevance 0.66
After this peak, plasma CCK levels gradually decreased.
Negative_regulation (decreased) of CCK in plasma associated with cholecystokinin
2) Confidence 0.59 Published 1993 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 8464169 Disease Relevance 0.15 Pain Relevance 0.38
Using the P77PMC strain of rat, which is genetically prone to audiogenic seizures, and also has decreased levels of cholecystokinin (CCK), we examined the analgesic response to peripheral electrical stimulation, which is, in part, opiate-mediated.
Negative_regulation (decreased) of cholecystokinin associated with epilepsy, analgesic, opiate, sprains and strains and cholecystokinin
3) Confidence 0.59 Published 1997 Journal Brain Res. Section Abstract Doc Link 9037405 Disease Relevance 0.20 Pain Relevance 0.88
Using the P77PMC strain of rat, which is genetically prone to audiogenic seizures, and also has decreased levels of cholecystokinin (CCK), we examined the analgesic response to peripheral electrical stimulation, which is, in part, opiate-mediated.
Negative_regulation (decreased) of CCK associated with epilepsy, analgesic, opiate, sprains and strains and cholecystokinin
4) Confidence 0.59 Published 1997 Journal Brain Res. Section Abstract Doc Link 9037405 Disease Relevance 0.20 Pain Relevance 0.89
In contrast, only celiac ganglionectomy in combination with vagotomy abolished the CCK-8 effect in vehicle-treated controls.
Negative_regulation (abolished) of CCK-8 associated with ganglionectomy
5) Confidence 0.59 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3136661 Disease Relevance 0.09 Pain Relevance 0.66
I(CCK) was also significantly reduced by the CCK(2) receptor antagonist, L-365,260, while it was not affected by the CCK(1) receptor antagonist, L-364,718.
Negative_regulation (reduced) of CCK associated with antagonist and cholecystokinin
6) Confidence 0.59 Published 2006 Journal Life Sci. Section Abstract Doc Link 16797032 Disease Relevance 0.37 Pain Relevance 1.04
The present data are consistent with previous reports that CCK blocks, and CCK antagonists enhance, opiate-induced analgesia in response to thermal pain stimuli.
Negative_regulation (blocks) of CCK associated with pain, antagonist, opiate and analgesia
7) Confidence 0.59 Published 1989 Journal Neuropharmacology Section Abstract Doc Link 2725851 Disease Relevance 0.27 Pain Relevance 1.85
Axotomy, but not inflammation, induced a moderate decrease in CCK- and MOR-LI in the dorsal horn.
Negative_regulation (decrease) of CCK in dorsal horn associated with inflammation, dorsal horn, opioid receptor and cholecystokinin
8) Confidence 0.59 Published 1999 Journal Brain Res. Section Abstract Doc Link 10612699 Disease Relevance 0.29 Pain Relevance 1.93
Low-dose morphine (5 mg/kg) decreased CCK33-LI in hypothalamus.
Negative_regulation (decreased) of CCK33 in hypothalamus associated with morphine
9) Confidence 0.59 Published 1980 Journal Am. J. Physiol. Section Abstract Doc Link 7001917 Disease Relevance 0 Pain Relevance 0.48
In rats treated neonatally with capsaicin there were significant reductions in substance P measured by radioimmunoassay in dorsal spinal cord, spinal ganglia, and coeliac ganglia, but concentrations of cholecystokinin octapeptide (CCK8) measured by radioimmunoassay were not decreased.
Neg (not) Negative_regulation (decreased) of cholecystokinin octapeptide in spinal cord associated with celiac disease, qutenza, cholecystokinin, spinal cord and substance p
10) Confidence 0.59 Published 1982 Journal Brain Res. Section Abstract Doc Link 6765219 Disease Relevance 0.10 Pain Relevance 0.49
High doses of capsaicin had no consistent effects on levels of cholecystokinin (CCK), vasoactive intestinal polypeptide, or somatostatin, although a transient decrease in CCK levels was observed 4 days after dosing.
Negative_regulation (decrease) of CCK associated with qutenza, somatostatin and cholecystokinin
11) Confidence 0.59 Published 1983 Journal J. Neurosci. Section Abstract Doc Link 6194277 Disease Relevance 0.16 Pain Relevance 1.10
However, the inhibitory effect of CCK was preserved as infusion of CCK was associated with a significant reduction in SO phasic amplitude and frequency, both before and after cholecystectomy.
Negative_regulation (effect) of CCK
12) Confidence 0.59 Published 1999 Journal Endoscopy Section Body Doc Link 10223364 Disease Relevance 0 Pain Relevance 0
These results may indicate a link between capsaicin-induced analgesia and the concomitant depletion of cholecystokinin and substance P.
Negative_regulation (depletion) of cholecystokinin associated with qutenza, cholecystokinin, substance p and analgesia
13) Confidence 0.58 Published 1983 Journal Neuroscience Section Abstract Doc Link 6188075 Disease Relevance 0 Pain Relevance 1.75
In this same area, IHC revealed modest reductions in CCK, gastrin, and substance P staining.
Negative_regulation (reductions) of CCK associated with cholecystokinin and substance p
14) Confidence 0.58 Published 1992 Journal J. Comp. Neurol. Section Abstract Doc Link 1479068 Disease Relevance 0 Pain Relevance 0.77
CCK levels were significantly reduced following electro-acupuncture in atropinized rats.
Negative_regulation (reduced) of CCK associated with acupuncture and cholecystokinin
15) Confidence 0.58 Published 1992 Journal Acta Physiol. Scand. Section Abstract Doc Link 1362318 Disease Relevance 0 Pain Relevance 0.52
This loss of the inhibitory effect of CCK on nociceptin after nerve injury may be of clinical interest in the treatment of neuropathic pain.
Negative_regulation (loss) of CCK in nerve associated with nervous system injury, orphanin, neuropathic pain and cholecystokinin
16) Confidence 0.58 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14744608 Disease Relevance 0.58 Pain Relevance 1.27
These effects of CCK-8S were abolished by tetrodotoxin (10(-6) M) and were not influenced by the CCK-A receptor antagonist loxiglumide (CR1505) (10(-7) M and 10(-6) M).
Negative_regulation (abolished) of CCK-8S associated with tetrodotoxin and antagonist
17) Confidence 0.58 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8587661 Disease Relevance 0 Pain Relevance 0.63
Anatomy and enzyme and peptide chemistry of peripheral nerve and spinal cord.

(1) Capsaicin solution was applied for 15 min around a 1 cm length of sciatic nerve in the mid upper leg of adult rats. (2) Electron microscopic examinations of the nerve in the treated region after 14 days shows no signs of degeneration of either myelinated or unmyelinated fibres attributable to the capsaicin. (3) Fluoride resistant acid phosphatase FRAP disappears from the central terminals of the treated nerve by 7 days. (4) 1.5 mM capsaicin is sufficient to product a complete reduction of FRAP in the spinal cord. (5) The peptides substance P and cholecystokinin (CCK) are markedly depleted in the region of spinal cord terminations of the treated nerve at 14 days. (6) Substance P and CCk are not affected in spinal cord regions other than in the unmyelinated afferent terminal zone.

Negative_regulation (depleted) of CCK in nerve associated with qutenza, sciatic nerve, cholecystokinin, unmyelinated, substance p and spinal cord
18) Confidence 0.58 Published 1981 Journal Pain Section Title Doc Link 6173830 Disease Relevance 0 Pain Relevance 1.06
If such a hypothesis is in fact true, then CCK blockade may be of clinical value in the treatment of pain.
Negative_regulation (blockade) of CCK associated with pain and cholecystokinin
19) Confidence 0.58 Published 1985 Journal Brain Res. Section Abstract Doc Link 3838690 Disease Relevance 0.27 Pain Relevance 1.95
In capsaicin-treated rats, the intracerebroventricular or intravenous infusion of L-364,718 inhibited CCK-8 effects.
Negative_regulation (inhibited) of CCK associated with qutenza, cholecystokinin and intracerebroventricular
20) Confidence 0.58 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038882 Disease Relevance 0 Pain Relevance 1.04

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