INT94327

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Context Info
Confidence 0.80
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.06
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
liver 1
brain 1
nucleus 1
Primary sensory neurons 1
T cells 1
Stat1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 15 99.28 Very High Very High Very High
cytokine 86 98.40 Very High Very High Very High
Potency 26 98.04 Very High Very High Very High
Eae 4 89.56 High High
Angina 2 88.64 High High
Neuropeptide 28 85.40 High High
fluoxetine 2 83.52 Quite High
cINOD 8 82.92 Quite High
depression 8 81.84 Quite High
sSRI 8 79.60 Quite High
Disease Link Frequency Relevance Heat
Depressive Disorder 2 95.40 Very High Very High Very High
Acute Coronary Syndrome 1 95.16 Very High Very High Very High
Weight Gain 2 90.24 High High
Death 72 89.12 High High
Cv General 3 Under Development 2 88.64 High High
Apoptosis 16 84.16 Quite High
INFLAMMATION 88 82.68 Quite High
Disease 26 70.68 Quite High
Depression 8 70.68 Quite High
Encephalitis 28 70.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primary sensory neurons respond to a vigorous excitation via the capsaicin receptor/TRPV1 cation channel by a phosphorylation of the Jak/STAT pathway as measured by phospho-STAT3, and of the Ras/Raf-MAPK pathway as measured by phospho-MAPK/ERK1/2.
Phosphorylation (phosphorylation) of STAT in Primary sensory neurons associated with qutenza
1) Confidence 0.80 Published 2006 Journal Pharmacology Section Abstract Doc Link 16788306 Disease Relevance 0 Pain Relevance 0.52
Western blot analyses of brain and liver tissue indicated that signal transducer and activator of transcripton (STAT1) was not phosphorylated following IFN-alpha administration, suggesting that the pegylated compounds may not have bound type I IFN receptors in the rat.
Neg (not) Phosphorylation (phosphorylated) of STAT1 in liver
2) Confidence 0.73 Published 2006 Journal Psychoneuroendocrinology Section Abstract Doc Link 17049181 Disease Relevance 0.37 Pain Relevance 0.47
driven STAT1 phosphorylation in T cells, whereas IL-6 activation of STAT3 was less sensitive.
Phosphorylation (phosphorylation) of STAT1 in T cells
3) Confidence 0.40 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.37
200 BD Bioscience), phospho-STAT1 (1?
Phosphorylation (phospho) of STAT1
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.06 Pain Relevance 0
receptors (data not shown), nor the phoshorylation of STAT1 induced by IFN?
Phosphorylation (phoshorylation) of STAT1
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.39 Pain Relevance 0.33
induced the rapid phosphorylation of STAT1 (Fig. 2A), with translocation of the protein into the nucleus (Fig. 2B).
Phosphorylation (phosphorylation) of STAT1 in nucleus
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.25 Pain Relevance 0.16
Western blot analyses of brain and liver tissue indicated that signal transducer and activator of transcripton (STAT1) was not phosphorylated following IFN-alpha administration, suggesting that the pegylated compounds may not have bound type I IFN receptors in the rat.
Neg (not) Phosphorylation (phosphorylated) of STAT1 in brain
7) Confidence 0.25 Published 2006 Journal Psychoneuroendocrinology Section Abstract Doc Link 17049181 Disease Relevance 0.37 Pain Relevance 0.47
signaling is tightly controlled at different levels, including dephosphorylation of p-STAT1 and the induction of the suppressor of cytokine signaling (SOCS) proteins [20].
Phosphorylation (dephosphorylation) of p-STAT1 associated with cytokine
8) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.35 Pain Relevance 0.27
IFN-gamma induces phosphorylation and nuclear translocation of transcription factor STAT-1, which initiates a specific program of gene induction.
Phosphorylation (phosphorylation) of STAT-1
9) Confidence 0.03 Published 2001 Journal Circulation Section Abstract Doc Link 11257077 Disease Relevance 0.26 Pain Relevance 0.21

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