INT94328

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Context Info
Confidence 0.31
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.86
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
Monocytes 2
Stat1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 6 99.12 Very High Very High Very High
cytokine 17 96.88 Very High Very High Very High
Inflammation 20 91.84 High High
Neuropeptide 7 50.00 Quite Low
Kinase C 6 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 6 99.12 Very High Very High Very High
Acute Coronary Syndrome 3 94.04 High High
INFLAMMATION 17 91.84 High High
Death 18 76.88 Quite High
Breast Cancer 1 64.12 Quite High
Brain Injury 1 32.16 Quite Low
Disease 4 29.84 Quite Low
Encephalitis 7 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
activated STAT-1 signaling and the nuclear translocation of the protein.
Localization (translocation) of STAT-1
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.34 Pain Relevance 0.05
CONCLUSIONS: Monocytes from UA patients exhibit a molecular fingerprint of recent IFN-gamma triggering, such as nuclear translocation of STAT-1 complexes and upregulation of IFN-gamma-inducible genes CD64 and IP-10, which suggests that monocytes are activated, at least in part, by IFN-gamma.
Localization (translocation) of STAT-1 in Monocytes
2) Confidence 0.03 Published 2001 Journal Circulation Section Body Doc Link 11257077 Disease Relevance 0 Pain Relevance 0
To explore whether monocyte activation is IFN-gamma driven, patients with unstable (UA) or stable angina (SA) were compared for nuclear translocation of STAT-1 complexes and upregulation of IFN-gamma-inducible genes CD64 and IP-10.
Localization (translocation) of STAT-1 in monocyte associated with angina
3) Confidence 0.03 Published 2001 Journal Circulation Section Abstract Doc Link 11257077 Disease Relevance 0.26 Pain Relevance 0.22
IFN-gamma induces phosphorylation and nuclear translocation of transcription factor STAT-1, which initiates a specific program of gene induction.
Localization (translocation) of STAT-1
4) Confidence 0.03 Published 2001 Journal Circulation Section Abstract Doc Link 11257077 Disease Relevance 0.26 Pain Relevance 0.21

General Comments

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