INT94331

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Context Info
Confidence 0.11
First Reported 2001
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.31
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG, CXCL10) extracellular region (IFNG, CXCL10) signal transduction (CXCL10)
cell-cell signaling (CXCL10)
Anatomy Link Frequency
Monocytes 2
T lymphocytes 1
IFNG (Homo sapiens)
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 11 100.00 Very High Very High Very High
Angina 4 98.04 Very High Very High Very High
Inflammation 10 96.12 Very High Very High Very High
cytokine 9 85.28 High High
antagonist 4 83.60 Quite High
metalloproteinase 6 78.88 Quite High
Opioid 1 52.08 Quite High
Inflammatory marker 2 50.00 Quite Low
Inflammatory response 1 24.96 Low Low
agonist 1 18.64 Low Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 4 98.04 Very High Very High Very High
INFLAMMATION 12 96.12 Very High Very High Very High
Leukemia 1 91.44 High High
Contact Dermatitis 28 91.24 High High
Acute Coronary Syndrome 2 82.44 Quite High
Dermatitis 4 81.48 Quite High
Cancer 62 80.40 Quite High
Hypersensitivity 11 67.12 Quite High
Apoptosis 39 64.76 Quite High
Lymphatic System Cancer 2 56.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IP-10 IFN-gamma-inducible chemokine IP-10
IFN-gamma Positive_regulation (inducible) of IP-10 associated with chemokine
1) Confidence 0.11 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.46 Pain Relevance 0.34
But here IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.
IFN-gamma Positive_regulation (induction) of IP-10 in T lymphocytes associated with inflammation
2) Confidence 0.02 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.60 Pain Relevance 0.27
To explore whether monocyte activation is IFN-gamma driven, patients with unstable (UA) or stable angina (SA) were compared for nuclear translocation of STAT-1 complexes and upregulation of IFN-gamma-inducible genes CD64 and IP-10.
IFN-gamma Positive_regulation (inducible) of IP-10 in monocyte associated with angina
3) Confidence 0.02 Published 2001 Journal Circulation Section Abstract Doc Link 11257077 Disease Relevance 0.26 Pain Relevance 0.22
CONCLUSIONS: Monocytes from UA patients exhibit a molecular fingerprint of recent IFN-gamma triggering, such as nuclear translocation of STAT-1 complexes and upregulation of IFN-gamma-inducible genes CD64 and IP-10, which suggests that monocytes are activated, at least in part, by IFN-gamma.
IFN-gamma Positive_regulation (inducible) of IP-10 in Monocytes
4) Confidence 0.02 Published 2001 Journal Circulation Section Body Doc Link 11257077 Disease Relevance 0 Pain Relevance 0

General Comments

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