INT94335

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 71
Total Number 71
Disease Relevance 50.69
Pain Relevance 23.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL10) extracellular space (CXCL10) extracellular region (CXCL10)
cell-cell signaling (CXCL10)
Anatomy Link Frequency
fibroblasts 6
plasma 5
monocyte 4
epithelial cells 3
endothelial cells 3
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1462 100.00 Very High Very High Very High
cytokine 1219 100.00 Very High Very High Very High
Inflammation 744 99.98 Very High Very High Very High
spinal inflammation 343 99.84 Very High Very High Very High
Arthritis 824 99.68 Very High Very High Very High
rheumatoid arthritis 677 99.60 Very High Very High Very High
Fibrositis 194 99.56 Very High Very High Very High
Multiple sclerosis 76 98.88 Very High Very High Very High
Angina 4 98.36 Very High Very High Very High
Inflammatory response 58 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Polyradiculoneuropathy 44 100.00 Very High Very High Very High
INFLAMMATION 830 99.98 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 69 99.88 Very High Very High Very High
Low Back Pain 345 99.84 Very High Very High Very High
Severe Acute Respiratory Syndrome 7 99.78 Very High Very High Very High
Seronegative Spondarthritis 307 99.68 Very High Very High Very High
Systemic Lupus Erythematosus 187 99.66 Very High Very High Very High
Rheumatoid Arthritis 694 99.60 Very High Very High Very High
Infection 649 99.60 Very High Very High Very High
Arthritis 527 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, peptidoglycan (PGN), double-stranded (ds) RNA or lipopolysaccharide (LPS) (TLR2, TLR3 or TLR4 ligands, respectively) synergized with interferon-gamma (IFN-gamma) at inducing CXCL9 and CXCL10.
Positive_regulation (inducing) of CXCL10
1) Confidence 0.58 Published 2006 Journal Lab. Invest. Section Abstract Doc Link 16847431 Disease Relevance 0.31 Pain Relevance 0.27
CXCL10 and interleukin-8) expression was observed in both microglia and astrocytes (p<0.05).
Positive_regulation (observed) of CXCL10 in astrocytes
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943470 Disease Relevance 2.69 Pain Relevance 0.21
We and others have reported that IP-10/CXCL10 was upregulated in the CNS fluid of NPSLE [9, 21].

3.1.3.

Positive_regulation (upregulated) of IP-10
3) Confidence 0.44 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.23 Pain Relevance 0.45
We and others have reported that IP-10/CXCL10 was upregulated in the CNS fluid of NPSLE [9, 21].

3.1.3.

Positive_regulation (upregulated) of CXCL10
4) Confidence 0.44 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.23 Pain Relevance 0.45
In addition, CD26 is coexpressed with CXCR3 on the infiltrating Th1 lymphocytes and natural killer cells, and rapidly inactivates CXCL10 by NH2-terminal processing [22,44].
Positive_regulation (inactivates) of CXCL10 in natural killer cells
5) Confidence 0.44 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.38 Pain Relevance 0.57
Similarly, transcript levels of CXCL10 and CXCL8 in HFAs were increased at 6 and 12 hr after HCV core protein application (Figure 3B and 3D, p<0.05).
Positive_regulation (increased) of CXCL10 associated with hepatitis c virus infection
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.01 Pain Relevance 0.27
to induce CXCL10 has previously been reported for several cell types, including leukocytes, epithelial cells, endothelial cells and fibroblasts [13-16].
Positive_regulation (induce) of CXCL10 in fibroblasts
7) Confidence 0.41 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.22 Pain Relevance 0.22
Synergistic induction of CXCL10 ligands in fibroblasts and endothelial cells by inflammatory cytokines.
Positive_regulation (induction) of CXCL10 in fibroblasts associated with inflammation and cytokine
8) Confidence 0.41 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.95 Pain Relevance 0.68
As shown here, synovial CXCL10 levels were significantly increased in AS, PsA and RA compared with levels in nonautoimmune CA.
Positive_regulation (increased) of CXCL10 associated with spinal inflammation, rheumatoid arthritis and arthritis
9) Confidence 0.41 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 1.64 Pain Relevance 0.87
is generally accepted to be the main endogenous inducer of CXCL10, which attracts and activates Th1 lymphocytes and natural killer cells [33].
Positive_regulation (inducer) of CXCL10 in lymphocytes
10) Confidence 0.41 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 1.09 Pain Relevance 0.87
Paradoxically, constant inflammatory signals provided by the significant increase in several chemokines (CCL2, CCL3, CCL19, CXCL8, CXCL10, CXCL11) and pro-inflammatory cytokines (IL6, IL17, IL1A, IL1B, TNF) in the lung cells may have resulted in massive infiltration of leucocytes and excessive tissue damage.
Positive_regulation (increase) of CXCL10 in lung associated with chemokine, inflammation and cytokine
11) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.61 Pain Relevance 0.29
Compared with CA patients, the median synovial CXCL10 levels were significantly enhanced in patients with RA (P < 10-7), in patients with AS (P < 10-4) and in patients with PsA (P < 10-4).
Positive_regulation (enhanced) of CXCL10 associated with spinal inflammation, rheumatoid arthritis and arthritis
12) Confidence 0.38 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 1.19 Pain Relevance 0.64
Compared with CA patients, the median synovial CXCL10 levels were significantly enhanced in patients with RA (P < 10-7), in patients with AS (P < 10-4) and in patients with PsA (P < 10-4).
Positive_regulation (synovial) of CXCL10 associated with spinal inflammation, rheumatoid arthritis and arthritis
13) Confidence 0.38 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 1.12 Pain Relevance 0.63
Similar to fibroblasts, synergistic CXCL10 induction occurred between IL-1?
Positive_regulation (induction) of CXCL10 in fibroblasts
14) Confidence 0.36 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.09 Pain Relevance 0.22
All three groups of autoimmune arthritis patients (ankylosing spondylitis, psoriatic arthritis and rheumatoid arthritis) had significantly increased synovial CXCL10 levels compared with crystal arthritis patients.
Positive_regulation (increased) of CXCL10 associated with seronegative spondarthritis, spinal inflammation, rheumatoid arthritis and arthritis
15) Confidence 0.36 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1779382 Disease Relevance 1.39 Pain Relevance 0.93
(Figure 3), however, only yielded a weak synergistic CXCL10 induction and the total CXCL10 production remained low (?
Positive_regulation (induction) of CXCL10
16) Confidence 0.36 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.06 Pain Relevance 0.12
To investigate whether DPP IV activity (or CD26 expression) could be upregulated in fibroblasts by cytokines under similar conditions to those used to induce CXCL10, cell cultures were stimulated with IL-1?
Positive_regulation (induce) of CXCL10 in fibroblasts associated with cytokine
17) Confidence 0.36 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0 Pain Relevance 0.05
Tears from the DED patients had significantly increased IP-10/CXCL10 levels.
Positive_regulation (increased) of IP-10 in Tears associated with eye disease
18) Confidence 0.35 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.84 Pain Relevance 0.40
Tears from the DED patients had significantly increased IP-10/CXCL10 levels.
Positive_regulation (increased) of CXCL10 in Tears associated with eye disease
19) Confidence 0.35 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.85 Pain Relevance 0.40
Human conjunctival epithelial cells in vitro secrete significantly increased amounts of IP-10/CXCL10 when stimulated by TNF-?
Positive_regulation (increased) of IP-10 in epithelial cells
20) Confidence 0.35 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.39 Pain Relevance 0.28

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