INT94337

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.66
Pain Relevance 3.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL10) extracellular space (CXCL10) extracellular region (CXCL10)
cell-cell signaling (CXCL10)
Anatomy Link Frequency
dental pulp 2
blood 1
coronary artery 1
mononuclear cells 1
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 180 100.00 Very High Very High Very High
pulpitis 4 99.92 Very High Very High Very High
cytokine 71 99.20 Very High Very High Very High
Inflammation 102 98.80 Very High Very High Very High
rheumatoid arthritis 110 95.56 Very High Very High Very High
Arthritis 53 95.36 Very High Very High Very High
Inflammatory response 8 87.12 High High
methotrexate 14 76.44 Quite High
Angina 5 68.72 Quite High
Inflammatory mediators 5 38.88 Quite Low
Disease Link Frequency Relevance Heat
Pulpitis 4 99.92 Very High Very High Very High
Coronary Artery Disease 24 99.44 Very High Very High Very High
INFLAMMATION 111 98.80 Very High Very High Very High
Hepatitis C Virus Infection 189 98.08 Very High Very High Very High
Infection 38 97.72 Very High Very High Very High
Atherosclerosis 6 96.36 Very High Very High Very High
Rheumatoid Arthritis 110 95.56 Very High Very High Very High
Juvenile Chronic Polyarthritis 40 95.36 Very High Very High Very High
Recurrence 3 92.00 High High
Disease 32 86.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Constitutive transcription of CXCL10 was demonstrated in all PBMCs, while CCL3 mRNA was readily detected in control PBMCs and seven of eight PBMCs from JIA patients. mRNA for CXCL10 and CCL3 were readily detected in all SFMC samples.
Transcription (transcription) of CXCL10 associated with arthritis
1) Confidence 0.49 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.58 Pain Relevance 0.40
expressed elevated levels of CXCL10 and CXCL8 transcripts (Figure 3A and 3C, p<0.05).
Transcription (levels) of CXCL10
2) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.06 Pain Relevance 0.31
CXCL10 mRNA expression levels in clinically inflamed dental pulp were higher than those in healthy dental pulp.
Transcription (expression) of CXCL10 in dental pulp
3) Confidence 0.45 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 18037659 Disease Relevance 0.34 Pain Relevance 0.43
CXCL10 mRNA expression levels in clinically inflamed dental pulp were higher than those in healthy dental pulp.
Transcription (levels) of CXCL10 in dental pulp
4) Confidence 0.45 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 18037659 Disease Relevance 0.34 Pain Relevance 0.43
As shown in Figure 2a, mRNA expression for two selected chemokines, CCL18 and CXCL10, was readily detectable in SF PMN but remained undetectable in peripheral blood PMN from the healthy donor.
Transcription (expression) of CXCL10 in blood associated with chemokine
5) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.39 Pain Relevance 0.28
Patients with CAD showed higher constitutive expression of CCL2, CXCL8, CXCL9, CXCL10 and IFN-gamma mRNA and, after stimulation with oxLDL, higher expression of CCL2 and CXCL8 mRNA than the control group.
Transcription (expression) of CXCL10 associated with coronary artery disease
6) Confidence 0.16 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18617279 Disease Relevance 0.96 Pain Relevance 0.30
We evaluated mRNA expression and protein production of CCL2, CXCL8, CXCL9, CXCL10, IFN-gamma and IL-10 in vitro as well as the expression of the CCR2 and CXCR3 receptors in peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD) and healthy controls in the presence or absence of oxidized LDL (oxLDL).
Transcription (expression) of CXCL10 in coronary artery associated with coronary artery disease
7) Confidence 0.15 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18617279 Disease Relevance 0.69 Pain Relevance 0.26
Patients with CAD showed higher constitutive expression of CCL2, CXCL8, CXCL9, CXCL10 and IFN-gamma mRNA and, after stimulation with oxLDL, higher expression of CCL2 and CXCL8 mRNA than the control group.
Transcription (expression) of CXCL10 associated with coronary artery disease
8) Confidence 0.15 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18617279 Disease Relevance 0.98 Pain Relevance 0.36
In synoviocytes, BEB3-crosslinked hTWEAK increased the mRNA level of IL-8, MCP-1, RANTES, IP-10 and MIP-1?.
Transcription (level) of IP-10
9) Confidence 0.11 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.24 Pain Relevance 0.13
However, no mRNA expression was observed for CCL18 and CXCL10 in PMN infected with A. phagocytophilum.


Transcription (expression) of CXCL10
10) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.64 Pain Relevance 0.49
METHODS AND RESULTS: Peripheral blood mononuclear cells were stained for expression of CD64 on CD14(+) monocytes and analyzed by PCR for transcription of IP-10.
Spec (analyzed) Transcription (transcription) of IP-10 in mononuclear cells
11) Confidence 0.07 Published 2001 Journal Circulation Section Body Doc Link 11257077 Disease Relevance 0 Pain Relevance 0
in humans, IP-10 mRNA was detected in BAL cells only in the nebulized patients and not subcutaneous rIFN-?
Neg (not) Transcription (detected) of IP-10
12) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737621 Disease Relevance 0.45 Pain Relevance 0.08

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