INT94347

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.25
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DYSF)
Anatomy Link Frequency
cardiomyocytes 1
skeletal muscle 1
DYSF (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 120 84.08 Quite High
headache 1 81.76 Quite High
Migraine 1 81.20 Quite High
Inflammation 22 78.32 Quite High
Inflammatory response 2 60.00 Quite High
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Onset of action 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 4 97.28 Very High Very High Very High
Muscle Disease 119 96.60 Very High Very High Very High
Muscular Dystrophy 49 95.56 Very High Very High Very High
Frailty 13 93.84 High High
Necrosis 7 93.00 High High
Muscle Weakness 6 92.56 High High
Disease 29 90.20 High High
Cognitive Disorder 1 82.20 Quite High
Headache 2 81.76 Quite High
Cramps 1 78.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dystrophin, dystrophin-associated proteins and dysferlin were normally expressed.
Gene_expression (expressed) of dysferlin
1) Confidence 0.75 Published 2000 Journal Rinsho Shinkeigaku Section Abstract Doc Link 11257789 Disease Relevance 1.40 Pain Relevance 0.16
The DYSF gene encodes a 230-kDa protein, which is normally expressed in the sarcolemma in skeletal muscle and which is absent in patients with LGMD2B or MM.
Gene_expression (expressed) of DYSF in skeletal muscle associated with muscle disease
2) Confidence 0.59 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2912795 Disease Relevance 0.54 Pain Relevance 0
Although DYSF is also expressed in cardiomyocytes, there is no evidence of cardiac muscle dysfunction in DYSF-deficient patients.
Gene_expression (expressed) of DYSF in cardiomyocytes
3) Confidence 0.59 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2912795 Disease Relevance 0.83 Pain Relevance 0.14
Dysferlinopathies (LGMD2B)
Gene_expression (Dysferlinopathies) of LGMD2B
4) Confidence 0.38 Published 2010 Journal Eur Radiol Section Body Doc Link PMC2940021 Disease Relevance 0.48 Pain Relevance 0.11

General Comments

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