INT94357

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 3.63
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neuronal 4
neurons 4
CoAO 2
spinal cord 2
paw 2
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
vanilloid receptor subtype 1 5 100.00 Very High Very High Very High
Inflammation 19 99.98 Very High Very High Very High
Neuropathic pain 8 99.68 Very High Very High Very High
spinal-cord stimulation 8 99.68 Very High Very High Very High
medulla 2 99.16 Very High Very High Very High
Eae 7 98.88 Very High Very High Very High
B1 receptor 101 97.88 Very High Very High Very High
intrathecal 20 96.96 Very High Very High Very High
qutenza 32 96.92 Very High Very High Very High
Dorsal horn 7 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 22 99.98 Very High Very High Very High
Neuropathic Pain 70 99.68 Very High Very High Very High
Hypersensitivity 2 98.56 Very High Very High Very High
Injury 1 96.92 Very High Very High Very High
Coronary Artery Disease 4 95.76 Very High Very High Very High
Hyperalgesia 27 95.12 Very High Very High Very High
Increased Venous Pressure Under Development 2 86.44 High High
Disease 2 79.32 Quite High
Fever 2 78.64 Quite High
Necrosis 5 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sustained (30 min to 4 h) exposure of cultured neurons to TNFalpha evoked a twofold increase in mRNA transcript (P<0.05) and protein levels (P<0.01) of transient potential receptor vanilloid type 1 (TRPV1).
Positive_regulation (increase) of Transcription (transcript) of TRPV1 in neurons
1) Confidence 0.50 Published 2008 Journal Neuroscience Section Abstract Doc Link 18582539 Disease Relevance 0.51 Pain Relevance 0.79
The elevation of the levels of VR1 mRNA and VR1 protein induced by exogenous galanin implicated that VR1 may be involved in the mechanisms of SP release evoked by capsaicin.


Positive_regulation (elevation) of Transcription (levels) of VR1
2) Confidence 0.50 Published 2008 Journal Neuro Endocrinol. Lett. Section Body Doc Link 19112407 Disease Relevance 0.06 Pain Relevance 0
The elevation of the levels of VR1 mRNA and VR1 protein induced by exogenous galanin implicated that VR1 may be involved in the mechanisms of SP release evoked by capsaicin.


Positive_regulation (elevation) of Transcription (levels) of VR1 protein
3) Confidence 0.50 Published 2008 Journal Neuro Endocrinol. Lett. Section Body Doc Link 19112407 Disease Relevance 0.06 Pain Relevance 0
The results showed that 1 could up-regulate the mRNA expression levels of TRPV1 at both 37 and 39 degrees C, and its calcium-mediating function was significantly increased at 39 degrees C, all of which could not be blocked by pretreatment of the neuronal cells with ruthenium red, a general transient receptor potential (TRP) blocker, indicating that the action of 1 was achieved through a non-TRPA1 channel pathway.
Positive_regulation (regulate) of Transcription (expression) of TRPV1 in neuronal
4) Confidence 0.47 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20390747 Disease Relevance 0.24 Pain Relevance 0
The results showed that 1 could up-regulate the mRNA expression levels of TRPV1 at both 37 and 39 degrees C, and its calcium-mediating function was significantly increased at 39 degrees C, all of which could not be blocked by pretreatment of the neuronal cells with ruthenium red, a general transient receptor potential (TRP) blocker, indicating that the action of 1 was achieved through a non-TRPA1 channel pathway.
Positive_regulation (increased) of Transcription (expression) of TRPV1 in neuronal
5) Confidence 0.47 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20390747 Disease Relevance 0.24 Pain Relevance 0
SCS attenuated the increase of SP and TRPV1 mRNA levels at T4 level induced by intermittent CoAO when the stimulation was applied prior to the initiation of the cardiac ischemia.
Positive_regulation (increase) of Transcription (levels) of TRPV1 in CoAO associated with coronary artery disease, ischemia and spinal-cord stimulation
6) Confidence 0.46 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17714867 Disease Relevance 0.40 Pain Relevance 0.75
VR1 mRNA expression increased in the small- and medium-sized DRG neurons from the first to 28th day after injury, and this up-regulation corresponded well with the development and maintenance of thermal hyperalgesia of the hind paw.
Positive_regulation (increased) of Transcription (expression) of VR1 in paw associated with vanilloid receptor subtype 1, thermal hyperalgesia and injury
7) Confidence 0.45 Published 2002 Journal Pain Section Abstract Doc Link 12237189 Disease Relevance 0.34 Pain Relevance 0.76
Sustained (30 min to 4 h) exposure of cultured neurons to TNFalpha evoked a twofold increase in mRNA transcript (P<0.05) and protein levels (P<0.01) of transient potential receptor vanilloid type 1 (TRPV1).
Positive_regulation (increase) of Transcription (transcript) of vanilloid type 1 in neurons
8) Confidence 0.44 Published 2008 Journal Neuroscience Section Abstract Doc Link 18582539 Disease Relevance 0.51 Pain Relevance 0.79
However, the increased mRNA level of TRPV1 in STZ was much less striking (3-fold) than that of B1R (27-fold), IL-1?
Positive_regulation (increased) of Transcription (level) of TRPV1 associated with b1 receptor
9) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.48 Pain Relevance 0.82
The enhanced mRNA expression (B1R, IL-1beta, TNF-alpha, TRPV1) and Iba-1 immunoreactivity in the STZ spinal cord were normalized by fluorocitrate or minocycline, yet B1R binding sites were reduced by 38%.
Positive_regulation (enhanced) of Transcription (expression) of TRPV1 in spinal cord
10) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link 20587056 Disease Relevance 0.16 Pain Relevance 0
Thus, peripheral inflammation induces the axonal transport of VR1 mRNA, which may be involved in the hypersensitivity of primary afferents to capsaicin and the production of inflammatory hyperalgesia.
Positive_regulation (induces) of Transcription (transport) of VR1 associated with hyperalgesia, qutenza, inflammation and hypersensitivity
11) Confidence 0.36 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11259480 Disease Relevance 0.63 Pain Relevance 1.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox