INT94367

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Context Info
Confidence 0.25
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ARRB1, TP53INP2) cytosol (ARRB1) plasma membrane (ARRB1)
transcription factor binding (ARRB1) cytoplasm (ARRB1)
Anatomy Link Frequency
I3L 1
embryonic kidney 1
ARRB1 (Homo sapiens)
TP53INP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 18 100.00 Very High Very High Very High
agonist 2 97.72 Very High Very High Very High
addiction 2 93.72 High High
tolerance 2 93.28 High High
analgesia 2 92.72 High High
opiate 2 92.00 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoprecipitation experiments demonstrated that beta-arrestin 1 physically interacts with delta opioid receptor (DOR) co-expressed in human embryonic kidney 293 cells in an agonist-enhanced manner and truncation of the carboxyl terminus of DOR partially impairs the interaction.
beta-arrestin Binding (interacts) of DOR in embryonic kidney associated with agonist and opioid receptor
1) Confidence 0.25 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11259507 Disease Relevance 0 Pain Relevance 0.67
Surface plasmon resonance determination further revealed that binding of CT and I3L of DOR to beta-arrestin is additive, suggesting these two domains bind at distinctly different sites on beta-arrestin without considerable spatial hindrance.
beta-arrestin Binding (binding) of DOR in I3L associated with opioid receptor
2) Confidence 0.25 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11259507 Disease Relevance 0 Pain Relevance 0.63

General Comments

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