INT94388

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 124
Total Number 127
Disease Relevance 79.48
Pain Relevance 31.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GDF15) extracellular space (GDF15) extracellular region (GDF15)
cell-cell signaling (GDF15)
Anatomy Link Frequency
colon 6
lung 3
LoVo 3
A549 2
cleavage 1
GDF15 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 510 100.00 Very High Very High Very High
cytokine 178 100.00 Very High Very High Very High
Inflammation 257 99.60 Very High Very High Very High
antagonist 108 99.44 Very High Very High Very High
Angina 50 99.32 Very High Very High Very High
Kinase C 24 99.04 Very High Very High Very High
agonist 138 97.32 Very High Very High Very High
cva 14 96.44 Very High Very High Very High
Cannabinoid receptor 3 95.36 Very High Very High Very High
diclofenac 1 89.08 High High
Disease Link Frequency Relevance Heat
Apoptosis 1164 100.00 Very High Very High Very High
INFLAMMATION 440 100.00 Very High Very High Very High
Cancer 547 99.84 Very High Very High Very High
Reprotox - General 1 60 99.84 Very High Very High Very High
Carcinoma 41 99.84 Very High Very High Very High
Colon Cancer 183 99.60 Very High Very High Very High
Prostate Cancer 12 99.60 Very High Very High Very High
Ovarian Cancer 44 99.58 Very High Very High Very High
Targeted Disruption 16 99.52 Very High Very High Very High
Stress 56 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of celecoxib on NAG-1 expression were abolished by pretreatment with GSK3beta inhibitor, SB216763.
Gene_expression (expression) of NAG-1
1) Confidence 0.77 Published 2007 Journal Cancer Lett. Section Abstract Doc Link 17257745 Disease Relevance 0.51 Pain Relevance 0.10
Celecoxib inhibited Ser473 Akt and Ser9 GSK3beta phosphorylation and induced upregulation of nonsteroidal anti-inflammatory drugs-activated gene-1 (NAG-1) expression.
Gene_expression (expression) of NAG-1 associated with inflammation and cinod
2) Confidence 0.77 Published 2007 Journal Cancer Lett. Section Abstract Doc Link 17257745 Disease Relevance 0.52 Pain Relevance 0.10
The retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN) greatly enhances the expression of NAG-1 mRNA and protein in a time- and dose-dependent manner in human lung adenocarcinoma H460 cells and several other carcinoma cell lines.
Gene_expression (expression) of NAG-1 mRNA in H460 associated with adenocarcinoma and carcinoma
3) Confidence 0.77 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12606762 Disease Relevance 0.58 Pain Relevance 0.21
In contrast to carcinoma cells, NAG-1 expression is effectively induced by retinoic acid and the RAR-selective pan-agonist in normal HTBE cells and accompanies the inhibition of squamous differentiation and the initiation of normal differentiation.
Gene_expression (expression) of NAG-1 associated with agonist and carcinoma
4) Confidence 0.77 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12606762 Disease Relevance 0.67 Pain Relevance 0.23
The induction of NAG-1 expression by AHPN is caused at least in part by an 8-fold increase in the stability of NAG-1 mRNA.
Gene_expression (expression) of NAG-1
5) Confidence 0.77 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12606762 Disease Relevance 0.61 Pain Relevance 0.23
In vivo, NAG-1 expression was observed in the normal tracheobronchial epithelium, whereas no expression was found in either squamous metaplastic tracheal epithelium or in sections of human lung tumors.
Gene_expression (expression) of NAG-1 in lung associated with lung cancer
6) Confidence 0.77 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12606762 Disease Relevance 0.67 Pain Relevance 0.22
Our results suggest that the induction of NAG-1 expression by retinoids in normal HTBE and lung carcinoma cells is regulated by distinct mechanisms and is associated with different biological processes.
Gene_expression (expression) of NAG-1 in lung associated with lung cancer
7) Confidence 0.77 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12606762 Disease Relevance 0.60 Pain Relevance 0.15
Moreover, prodigiosin caused AKT dephosphorylation and glycogen synthase kinase-3beta (GSK-3beta) activation, which correlated with NAG-1 expression.
Gene_expression (expression) of NAG-1
8) Confidence 0.75 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17237295 Disease Relevance 0.66 Pain Relevance 0.08
The over-expression of NAG-1 in cancer cells results in growth arrest and increase in apoptosis, suggesting that NAG-1 has anti-tumorigenic activity.
Gene_expression (over-expression) of NAG-1 associated with cancer and apoptosis
9) Confidence 0.74 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17129398 Disease Relevance 0.65 Pain Relevance 0.17
The expression of NAG-1 can be increased by treatment with drugs and chemicals documented to prevent tumor formation and development.
Gene_expression (expression) of NAG-1 associated with cancer
10) Confidence 0.74 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17129398 Disease Relevance 0.98 Pain Relevance 0.14
Thus, NAG-1 expression is regulated by tumor suppressor pathways and appears to modulate tumor progression.
Gene_expression (expression) of NAG-1 associated with cancer
11) Confidence 0.74 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17129398 Disease Relevance 0.89 Pain Relevance 0.07
The induction of NAG-1 expression preceded the induction of apoptosis.
Gene_expression (expression) of NAG-1 associated with apoptosis
12) Confidence 0.74 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18076062 Disease Relevance 1.31 Pain Relevance 0.69
In contrast, NAG-1 expression and apoptosis were not induced by NSAIDs or conditioned medium in NHNE cells.
Gene_expression (expression) of NAG-1 associated with cinod and apoptosis
13) Confidence 0.74 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18076062 Disease Relevance 1.32 Pain Relevance 0.63
In this study, we investigated the induction of apoptosis in sinonasal cancer cells treated by various NSAIDs and the role of NAG-1 expression in this induction.
Gene_expression (expression) of NAG-1 associated with cancer, cinod and apoptosis
14) Confidence 0.74 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18076062 Disease Relevance 1.03 Pain Relevance 0.71
Furthermore, the mixture of I3C with resveratrol enhances NAG-1 expression, suggesting the synergistic effect of these two unrelated compounds on NAG-1 expression.
Gene_expression (expression) of NAG-1
15) Confidence 0.74 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15670751 Disease Relevance 0.28 Pain Relevance 0.06
Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner.
Gene_expression (expression) of NAG-1 associated with cytokine
16) Confidence 0.74 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 15670751 Disease Relevance 0.32 Pain Relevance 0.14
Furthermore, the mixture of I3C with resveratrol enhances NAG-1 expression, suggesting the synergistic effect of these two unrelated compounds on NAG-1 expression.
Gene_expression (expression) of NAG-1
17) Confidence 0.74 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15670751 Disease Relevance 0.27 Pain Relevance 0.06
In addition, DIM increased the expression of NAG-1 as well as activating transcription factor 3 (ATF3), and the induction of ATF3 was earlier than that of NAG-1.
Gene_expression (expression) of NAG-1
18) Confidence 0.74 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15670751 Disease Relevance 0.31 Pain Relevance 0.08
The induction of apoptosis in cells of human colon cancer cell lines after gamma irradiation was investigated to determine whether apoptosis was mediated by TP53 and the subsequent expression of its downstream target, the NSAID-activated gene (NAG1).
Gene_expression (expression) of NAG1 in colon associated with colon cancer, cinod and apoptosis
19) Confidence 0.72 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.68 Pain Relevance 0.17
The expression of TP53 protein in HCT116 cells was increased after irradiation and was followed by an increase in the expression of NAG1 protein.
Gene_expression (expression) of NAG1 protein
20) Confidence 0.72 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.94 Pain Relevance 0.15

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