INT94390

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 67
Total Number 68
Disease Relevance 45.50
Pain Relevance 14.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GDF15) extracellular space (GDF15) extracellular region (GDF15)
cell-cell signaling (GDF15)
Anatomy Link Frequency
LoVo 8
A549 4
colon 2
cleavage 2
lung 2
GDF15 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 267 100.00 Very High Very High Very High
cytokine 84 100.00 Very High Very High Very High
Kinase C 12 99.28 Very High Very High Very High
agonist 70 98.24 Very High Very High Very High
antagonist 50 94.48 High High
Inflammation 22 85.32 High High
aspirin 36 80.76 Quite High
Cannabinoid receptor 1 73.84 Quite High
COX2 10 25.00 Low Low
Pain 4 19.36 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 651 100.00 Very High Very High Very High
INFLAMMATION 105 100.00 Very High Very High Very High
Stress 36 99.98 Very High Very High Very High
Cancer 305 99.84 Very High Very High Very High
Carcinoma 29 99.84 Very High Very High Very High
Reprotox - General 1 22 99.84 Very High Very High Very High
Colon Cancer 103 99.60 Very High Very High Very High
Lung Cancer 56 98.76 Very High Very High Very High
Adenocarcinoma 8 97.44 Very High Very High Very High
Intestinal Cancer 6 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to carcinoma cells, NAG-1 expression is effectively induced by retinoic acid and the RAR-selective pan-agonist in normal HTBE cells and accompanies the inhibition of squamous differentiation and the initiation of normal differentiation.
Positive_regulation (induced) of Gene_expression (expression) of NAG-1 associated with agonist and carcinoma
1) Confidence 0.69 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12606762 Disease Relevance 0.68 Pain Relevance 0.23
The retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN) greatly enhances the expression of NAG-1 mRNA and protein in a time- and dose-dependent manner in human lung adenocarcinoma H460 cells and several other carcinoma cell lines.
Positive_regulation (enhances) of Gene_expression (expression) of NAG-1 mRNA in H460 associated with adenocarcinoma and carcinoma
2) Confidence 0.69 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12606762 Disease Relevance 0.58 Pain Relevance 0.21
The induction of NAG-1 expression by AHPN is caused at least in part by an 8-fold increase in the stability of NAG-1 mRNA.
Positive_regulation (induction) of Gene_expression (expression) of NAG-1
3) Confidence 0.69 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12606762 Disease Relevance 0.62 Pain Relevance 0.23
Our results suggest that the induction of NAG-1 expression by retinoids in normal HTBE and lung carcinoma cells is regulated by distinct mechanisms and is associated with different biological processes.
Positive_regulation (induction) of Gene_expression (expression) of NAG-1 in lung associated with lung cancer
4) Confidence 0.69 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12606762 Disease Relevance 0.60 Pain Relevance 0.15
The expression of NAG-1 can be increased by treatment with drugs and chemicals documented to prevent tumor formation and development.
Positive_regulation (increased) of Gene_expression (expression) of NAG-1 associated with cancer
5) Confidence 0.66 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17129398 Disease Relevance 0.99 Pain Relevance 0.14
The over-expression of NAG-1 in cancer cells results in growth arrest and increase in apoptosis, suggesting that NAG-1 has anti-tumorigenic activity.
Positive_regulation (over-expression) of Gene_expression (over-expression) of NAG-1 associated with cancer and apoptosis
6) Confidence 0.66 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17129398 Disease Relevance 0.65 Pain Relevance 0.17
In contrast, NAG-1 expression and apoptosis were not induced by NSAIDs or conditioned medium in NHNE cells.
Neg (not) Positive_regulation (induced) of Gene_expression (expression) of NAG-1 associated with cinod and apoptosis
7) Confidence 0.66 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18076062 Disease Relevance 1.33 Pain Relevance 0.63
The induction of NAG-1 expression preceded the induction of apoptosis.
Positive_regulation (induction) of Gene_expression (expression) of NAG-1 associated with apoptosis
8) Confidence 0.66 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18076062 Disease Relevance 1.32 Pain Relevance 0.69
Furthermore, the mixture of I3C with resveratrol enhances NAG-1 expression, suggesting the synergistic effect of these two unrelated compounds on NAG-1 expression.
Positive_regulation (enhances) of Gene_expression (expression) of NAG-1
9) Confidence 0.66 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15670751 Disease Relevance 0.28 Pain Relevance 0.06
Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner.
Positive_regulation (induce) of Gene_expression (expression) of NAG-1 associated with cytokine
10) Confidence 0.66 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 15670751 Disease Relevance 0.32 Pain Relevance 0.14
The expression of TP53 protein in HCT116 cells was increased after irradiation and was followed by an increase in the expression of NAG1 protein.
Positive_regulation (increase) of Gene_expression (expression) of NAG1 protein
11) Confidence 0.64 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.95 Pain Relevance 0.15
In contrast, the expression of NAG1 protein in TP53 mutant cells and TP53(-/-) cells was not increased by the radiation treatment, suggesting that NAG1 was required for apoptosis.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of NAG1 protein associated with apoptosis
12) Confidence 0.64 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.97 Pain Relevance 0.15
Furthermore, GSK3beta gene silencing by siRNA inhibited the celecoxib-induced NAG-1 expression.
Positive_regulation (induced) of Gene_expression (expression) of NAG-1
13) Confidence 0.60 Published 2007 Journal Cancer Lett. Section Abstract Doc Link 17257745 Disease Relevance 0.49 Pain Relevance 0.09
Although NAG-1 is a p53-responsive gene, AHPN-induced NAG-1 expression does not require p53.
Neg (not) Positive_regulation (-) of Gene_expression (expression) of NAG-1
14) Confidence 0.60 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12606762 Disease Relevance 0.62 Pain Relevance 0.23
PI3K inhibition by LY294002 showed an increase in NAG-1 protein and mRNA expression, and 1l-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate (AKT inhibitor) also induced NAG-1 expression.
Positive_regulation (induced) of Gene_expression (expression) of NAG-1
15) Confidence 0.59 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15377673 Disease Relevance 0.56 Pain Relevance 0.22
Most notable is the increase in NAG-1 expression by the inhibitors of cyclooxygenases that prevent human colorectal cancer development.
Positive_regulation (increase) of Gene_expression (expression) of NAG-1 associated with colon cancer
16) Confidence 0.58 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17129398 Disease Relevance 0.96 Pain Relevance 0.13
In AMC-HN5 human sinonasal carcinoma cells, indomethacin was the most potent NAG-1 inducer and caused NAG-1 expression in a time- and dose-dependent manner.
Positive_regulation (caused) of Gene_expression (expression) of NAG-1 associated with carcinoma
17) Confidence 0.58 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18076062 Disease Relevance 1.29 Pain Relevance 0.71
Treatment with MCC-555 resulted in the induction of NAG-1 expression and apoptosis in HCT-116 cells.
Positive_regulation (induction) of Gene_expression (expression) of NAG-1 associated with apoptosis
18) Confidence 0.57 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731769 Disease Relevance 0.79 Pain Relevance 0.10
Inhibition of GSK-3beta, which is negatively regulated by AKT, using AR-A014418 and lithium chloride completely abolished LY294002-induced NAG-1 expression as well as the NAG-1 promoter activity.
Positive_regulation (induced) of Gene_expression (expression) of NAG-1
19) Confidence 0.51 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15377673 Disease Relevance 0.51 Pain Relevance 0.20
Celecoxib inhibited Ser473 Akt and Ser9 GSK3beta phosphorylation and induced upregulation of nonsteroidal anti-inflammatory drugs-activated gene-1 (NAG-1) expression.
Positive_regulation (drugs-activated) of Gene_expression (expression) of NAG-1 associated with inflammation and cinod
20) Confidence 0.50 Published 2007 Journal Cancer Lett. Section Abstract Doc Link 17257745 Disease Relevance 0.52 Pain Relevance 0.10

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