INT94393

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Context Info
Confidence 0.17
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.02
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANGPT2) signal transduction (ANGPT2) extracellular space (ANGPT2)
extracellular region (ANGPT2) plasma membrane (ANGPT2) nucleus (ANGPT2)
Anatomy Link Frequency
neurons 1
brain 1
endothelium 1
smooth muscle cells 1
vascular endothelium 1
ANGPT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 48 99.68 Very High Very High Very High
agonist 6 98.48 Very High Very High Very High
Inflammation 64 94.04 High High
Inflammatory response 5 88.68 High High
cva 11 82.96 Quite High
cytokine 26 82.88 Quite High
tetrodotoxin 1 76.48 Quite High
Neuronal excitability 1 58.80 Quite High
Neurotransmitter 1 56.36 Quite High
Clonidine 1 49.52 Quite Low
Disease Link Frequency Relevance Heat
Volume Depletion And Dehydration 1 99.20 Very High Very High Very High
Atherosclerosis 106 98.18 Very High Very High Very High
Increased Venous Pressure Under Development 57 97.40 Very High Very High Very High
Cardiovascular Disease 39 95.92 Very High Very High Very High
INFLAMMATION 67 94.04 High High
Injury 19 93.76 High High
Stress 86 92.44 High High
Natriuresis 5 92.16 High High
Hemorrhage 2 90.32 High High
Hyperlipidemia 11 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies identify multiple postsynaptic modulatory sites through which ANG II can influence the excitability of neurosecretory parvocellular PVN neurons and, as a consequence of such actions, control hormonal secretion from the anterior pituitary.
Localization (secretion) of ANG II in neurons
1) Confidence 0.17 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15831764 Disease Relevance 0 Pain Relevance 0.13
The antiatherogenic ACE-I properties may be related both to the inhibition of tissue and circulating Ang II formation and to bradykinin potentiation, resulting in decreased proliferation and migration of smooth muscle cells, decreased accumulation and activation of inflammatory cells, decreased oxidative stress, and increased endothelial NO formation, leading to improved endothelial function.
Localization (formation) of Ang II in smooth muscle cells associated with stress, inflammation and bradykinin
2) Confidence 0.14 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.82 Pain Relevance 0.14
Generation of Ang II is regulated by a circulating RAAS and a tissue angiotensin system, both of which are upregulated in cardiovascular diseases (Dzau and Re 1994).
Localization (Generation) of Ang II associated with cardiovascular disease
3) Confidence 0.14 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.39 Pain Relevance 0.12
In animal models, ACE-I can retard the development of atherosclerosis, and these antiatherogenic properties can be related to the inhibition of angiotensin-II (Ang II) formation and to the inhibition of bradykinin degradation, which promotes vasodilatation by stimulating the production of arachidonic acid metabolites and nitric oxide (NO) in vascular endothelium.
Localization (formation) of Ang II in vascular endothelium associated with atherosclerosis, increased venous pressure under development and bradykinin
4) Confidence 0.14 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.94 Pain Relevance 0.15
Similarly, Ang II decreased and remained below placebo for 48 hours (P < 0.05).
Localization (decreased) of Ang II
5) Confidence 0.13 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 0.07 Pain Relevance 0
Within the brain ANP inhibits drinking induced by ANG-II and blocks dehydration-induced drinking known to be caused by release of ANG-II.
Localization (release) of ANG-II in brain associated with volume depletion and dehydration
6) Confidence 0.04 Published 2001 Journal Brain Res. Section Abstract Doc Link 11259763 Disease Relevance 0.27 Pain Relevance 0.16
Through release of promoters and inhibitors of growth and differentiation of the VSMC, such as platelet-derived growth factor (PDGF) and ANG-II, endothelium also has an impact on vascular remodeling [11].
Localization (release) of ANG-II in endothelium
7) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.14 Pain Relevance 0.14
Under physiological circumstances, there is a balanced release of endothelial-derived relaxing factors such as nitric oxide (NO) and prostacyclin (PGI2), and contracting factors such as endothelin-1 (ET-1), prostaglandins, and angiotensin II (ANG-II).
Localization (release) of ANG-II
8) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.31 Pain Relevance 0.11

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