INT94396

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2007
Negated 3
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.37
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
Anatomy Link Frequency
liver 1
Cyp1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 15 97.16 Very High Very High Very High
headache 2 47.92 Quite Low
Bioavailability 3 47.40 Quite Low
topical agent 4 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 5 81.84 Quite High
Injury 3 73.36 Quite High
Headache 2 47.92 Quite Low
Gastrointestinal Disease 1 47.40 Quite Low
Mucositis 1 43.28 Quite Low
Candida Infection 93 21.52 Low Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 52 19.12 Low Low
Fungal Infection 35 5.00 Very Low Very Low Very Low
Infection 13 5.00 Very Low Very Low Very Low
Recurrence 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicated that rutaecarpine was a CYP1A inducer and showed potent inductive effects on both CYP1A1 and CYP1A2 in the liver.
Regulation (effects) of CYP1A2 in liver
1) Confidence 0.60 Published 2001 Journal Life Sci. Section Abstract Doc Link 11787945 Disease Relevance 0 Pain Relevance 0
Results showed that the catalytic activity and polypeptide levels of CYP1A2, CYP2E1, and CYP3A were unchanged in the treatment groups compared to vehicle and untreated controls.
Neg (unchanged) Regulation (unchanged) of CYP1A2
2) Confidence 0.43 Published 2001 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 11437634 Disease Relevance 0.30 Pain Relevance 0.77
Following retinol treatment, renal CYP2E1 and hepatic CYP1A2 and CYP2E1 catalytic activities and polypeptide levels were unchanged.
Neg (unchanged) Regulation (unchanged) of CYP1A2
3) Confidence 0.37 Published 2001 Journal Food Chem. Toxicol. Section Abstract Doc Link 11259846 Disease Relevance 0.07 Pain Relevance 0.39
An evaluation of the effects of posaconazole on the various CYP450 enzymes demonstrated an inhibitory effect on CYP3A4 activity, but no influence on the activity of the other isoenzymes (CYP1A2, CYP2C8/9, CYP2D6 or CYP2E1) (Wexler et al 2004).
Neg (no) Regulation (influence) of CYP1A2
4) Confidence 0.03 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2374940 Disease Relevance 0 Pain Relevance 0

General Comments

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