INT94397

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Context Info
Confidence 0.04
First Reported 2001
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.44
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp4f18) endoplasmic reticulum (Cyp4f18)
Cyp4f18 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 9 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acute Liver Failure 6 94.64 High High
Hepatotoxicity 2 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The potentiation effect could be mediated by retinol's induction of CYP450 isoforms relevant to paracetamol metabolism or through depletion of glutathione.
Positive_regulation (induction) of CYP450 associated with paracetamol
1) Confidence 0.04 Published 2001 Journal Food Chem. Toxicol. Section Abstract Doc Link 11259846 Disease Relevance 0.08 Pain Relevance 0.36
In this prospective randomized study we describe the selective induction of CYP450 enzymes, depletion of glutathione, and hepatotoxic insult using acetaminophen in the development and characterization of a novel rabbit model of acute hepatic failure.
Positive_regulation (induction) of CYP450 associated with paracetamol and acute liver failure
2) Confidence 0.00 Published 2002 Journal J. Surg. Res. Section Abstract Doc Link 12175977 Disease Relevance 0.26 Pain Relevance 0.17
After preliminary dose ranging experiments, two groups of New Zealand white (n = 8 in each group) rabbits had CYP450 induction with phenobarbitone (40 mg/kg ip for 5 days) or with 20-methylcholanthrene (80 mg/kg ip).
Positive_regulation (induction) of CYP450
3) Confidence 0.00 Published 2002 Journal J. Surg. Res. Section Body Doc Link 12175977 Disease Relevance 0.09 Pain Relevance 0

General Comments

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