INT944

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Context Info
Confidence 0.43
First Reported 1979
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 3.39
Pain Relevance 4.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 3
muscle 1
sympathetic 1
proximal 1
bowel 1
Mln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 8 100.00 Very High Very High Very High
tetrodotoxin 9 99.96 Very High Very High Very High
substance P 6 98.08 Very High Very High Very High
spastic colon 19 97.32 Very High Very High Very High
Pain 3 97.28 Very High Very High Very High
Spinal cord 10 95.36 Very High Very High Very High
antagonist 4 93.60 High High
abdominal pain 3 92.32 High High
opiate 2 92.16 High High
agonist 4 91.76 High High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

18 99.38 Very High Very High Very High
Functional Bowel Disorder 6 97.32 Very High Very High Very High
Pain 4 97.28 Very High Very High Very High
Frailty 8 95.36 Very High Very High Very High
Diarrhoea 1 92.92 High High
Congenital Anomalies 4 91.68 High High
Syndrome 1 88.72 High High
Constipation 2 79.32 Quite High
Ileus 2 78.60 Quite High
Abdominal Pain 3 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The action of motilin was unaffected by extrinsic denervation (cervical vagotomy or splanchnicectomy), hexamethonium, and propranolol.
Neg (unaffected) Negative_regulation (unaffected) of motilin
1) Confidence 0.43 Published 1988 Journal Gastroenterology Section Abstract Doc Link 3410223 Disease Relevance 0 Pain Relevance 0.18
Tissue section autoradiography in the antrum revealed that specific labeled motilin binding sites were localized in the circular muscle layer and myenteric plexus, and could be reduced in the presence of an excess of EM574.
Negative_regulation (reduced) of motilin in muscle
2) Confidence 0.43 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9088872 Disease Relevance 0 Pain Relevance 0.19
The 'extra'-contraction to motilin was not blocked by tetrodotoxin (1 microgram/ml) nor by atropine (10(-7) M), but acetylcholine (10(-5) M) was blocked by atropine.
Negative_regulation (blocked) of motilin associated with tetrodotoxin
3) Confidence 0.42 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2725711 Disease Relevance 0 Pain Relevance 0.14
Responses to motilin were partially inhibited by hexamethonium perfusion (15 micrograms/ml) suggesting that motilin acts, in part, on preganglionic neural elements proximal to nicotinic cholinergic synapses within the enteric nervous system.
Negative_regulation (inhibited) of motilin in proximal
4) Confidence 0.42 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3792443 Disease Relevance 0 Pain Relevance 0.20
This study explored ghrelin and motilin concentrations in plasma in relation to gastrointestinal motility and whether plasma ghrelin is changed in patients with irritable bowel syndrome (IBS).
Negative_regulation (explored) of motilin in plasma associated with spastic colon
5) Confidence 0.34 Published 2010 Journal Peptides Section Abstract Doc Link 20338210 Disease Relevance 0.17 Pain Relevance 0.41
In fasting studies, there was a trend (P = 0.23) toward increased fasting serum motilin in paraplegic patients, and this result did not support tonic inhibition of motilin release.
Negative_regulation (inhibition) of motilin
6) Confidence 0.23 Published 1995 Journal Am J Phys Med Rehabil Section Abstract Doc Link 7576409 Disease Relevance 0.56 Pain Relevance 0.19
In constipated patients fasting levels of gastrin and motilin and postprandial levels of gastrin, motilin and PP were decreased.
Negative_regulation (decreased) of motilin
7) Confidence 0.19 Published 1987 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 3477012 Disease Relevance 0.33 Pain Relevance 0.70
Blood samples were taken 30 min before and after each rectal distension procedure to determine plasma levels of cholecystokinin (CCK), pancreatic polypeptide (PP) and motilin.
Spec (determine) Negative_regulation (levels) of motilin in plasma associated with cholecystokinin
8) Confidence 0.15 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18761628 Disease Relevance 0.27 Pain Relevance 0.43
We hypothesized that abdominal sympathetic pathways provide tonic inhibition of peptide YY and motilin release and that postprandial increases in these gut hormones are mediated through spinal pathways.
Negative_regulation (inhibition) of motilin in sympathetic
9) Confidence 0.14 Published 1995 Journal Am J Phys Med Rehabil Section Abstract Doc Link 7576409 Disease Relevance 0.64 Pain Relevance 0.20
Pretreatment with tetrodotoxin (TTX) attenuated the motilin- and bombesin-induced contraction, but not the SP-induced contraction and VIP-induced relaxation.
Negative_regulation (attenuated) of motilin associated with tetrodotoxin and substance p
10) Confidence 0.14 Published 1996 Journal Peptides Section Abstract Doc Link 8899810 Disease Relevance 0 Pain Relevance 0.69
After the injection of FK, the plasma level of motilin markedly decreased from the baseline value of 456 +/- 70.2 pg/ml to 264 +/- 44.7 pg/ml at 120 min.
Negative_regulation (decreased) of motilin in plasma
11) Confidence 0.11 Published 1986 Journal Gastroenterol. Jpn. Section Abstract Doc Link 3770354 Disease Relevance 0 Pain Relevance 0.43
Fasting and postprandial levels of gastrin, insulin, gastric inhibitory polypeptide, pancreatic polypeptide, motilin, enteroglucagon and neurotensin were measured in 42 patients with irritable bowel syndrome (IBS).
Negative_regulation (levels) of motilin in bowel associated with spastic colon
12) Confidence 0.03 Published 1981 Journal Digestion Section Abstract Doc Link 7215725 Disease Relevance 0.34 Pain Relevance 0.34
There was significant blunting of insulin and gastric inhibitory polypeptide secretion, with complete abolition of the normal postprandial increases in pancreatic polypeptide and motilin.
Negative_regulation (abolition) of motilin
13) Confidence 0.03 Published 1983 Journal Am. J. Gastroenterol. Section Abstract Doc Link 6846306 Disease Relevance 0 Pain Relevance 0.25
The effects of motilin, neurotensin, and thyrotropin-releasing hormone were greatly reduced or abolished by perfusion of the preparation with tetrodotoxin.
Negative_regulation (reduced) of motilin associated with tetrodotoxin
14) Confidence 0.02 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 115560 Disease Relevance 0 Pain Relevance 0.54
MLN-4760 (ACE2 inhibitor) was obtained from Millennium Pharmaceuticals (Cambridge, MA).
Negative_regulation (inhibitor) of MLN-4760
15) Confidence 0.01 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.06 Pain Relevance 0.06

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