INT9440

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Context Info
Confidence 0.38
First Reported 1992
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 3.66
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MSMB) extracellular region (MSMB) nucleus (MSMB)
molecular_function (MSMB) biological_process (MSMB)
Anatomy Link Frequency
B cells 1
PSP 1
MSMB (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 43 100.00 Very High Very High Very High
Paracetamol 11 99.64 Very High Very High Very High
alcohol 2 98.36 Very High Very High Very High
shoulder pain 8 89.68 High High
backache 1 86.80 High High
cytokine 10 85.60 High High
Rheumatism 1 59.92 Quite High
headache 10 5.00 Very Low Very Low Very Low
Potency 10 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 42 100.00 Very High Very High Very High
Onchocerciasis 6 100.00 Very High Very High Very High
Nicotine Addiction 5 97.36 Very High Very High Very High
Sprains And Strains 16 91.52 High High
Shoulder Pain 8 89.68 High High
Malaria 175 87.04 High High
Low Back Pain 1 86.80 High High
Stress 1 84.44 Quite High
Hepatotoxicity 3 75.00 Quite High
Intestinal Volvulus 1 72.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With a significant association with onchocerciasis, MSP has the potential of being an important operational diagnostic clue in the detection of onchocerciasis.
MSP Binding (association) of associated with onchocerciasis and pain
1) Confidence 0.38 Published 1992 Journal Angew Parasitol Section Abstract Doc Link 1416218 Disease Relevance 1.21 Pain Relevance 0.56
When PSP was given to rats subchronically for 7 days (300 mg/kg/day, i.p.), the subsequent microsomes obtained also showed a 25% decrease in covalent binding to [14C]-paracetamol, suggesting that PSP interacted with the microsomal proteins rather than the chemically reactive metabolite of paracetamol.
PSP Binding (interacted) of in PSP associated with paracetamol
2) Confidence 0.29 Published 1994 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 7723471 Disease Relevance 0.22 Pain Relevance 0.81
A cross-sectional epidemiologic study was conducted to determine the prevalence of self-reported musculoskeletal pain (MSP) in construction workers and identify associations between MSP and individual factors (i.e., job, age, alcohol consumption, and smoking).
MSP Binding (associations) of associated with pain, nicotine addiction and alcohol
3) Confidence 0.04 Published 1999 Journal Ind Health Section Abstract Doc Link 10547961 Disease Relevance 1.18 Pain Relevance 1.09
The highly conserved C-terminal 19-kDa domain of MSP142 is preferentially recognized by antibodies.
MSP142 Binding (recognized) of
4) Confidence 0.01 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1847697 Disease Relevance 0.28 Pain Relevance 0
These data indicate that both the conserved 19-kDa domain and the dimorphic 33-kDa region of MSP142 are recognized by B cells and stimulate antibody responses.
MSP142 Binding (recognized) of in B cells
5) Confidence 0.01 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1847697 Disease Relevance 0.17 Pain Relevance 0
Antibodies generated following vaccination with either MSP142-FVO/Alhydrogel or MSP142-3D7/Alhydrogel were highly cross-reactive in their ability to recognize the FVO or 3D7 form of MSP142 and MSP119, whereas the low-level antibody to the dimorphic MSP133 region as allele-specific.
MSP119 Binding (recognize) of
6) Confidence 0.01 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1847697 Disease Relevance 0.26 Pain Relevance 0.08
Antibodies generated following vaccination with either MSP142-FVO/Alhydrogel or MSP142-3D7/Alhydrogel were highly cross-reactive in their ability to recognize the FVO or 3D7 form of MSP142 and MSP119, whereas the low-level antibody to the dimorphic MSP133 region as allele-specific.
MSP142 Binding (recognize) of
7) Confidence 0.01 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1847697 Disease Relevance 0.26 Pain Relevance 0.07
In contrast, data from this clinical trial showed MSP142-FVO/Alhydrogel and MSP142-3D7/Alhydrogel were equally immunogenic, and the antibodies elicited by each vaccine recognized the homologous and heterologous MSP142 recombinant proteins and native parasite proteins qualitatively similarly.
MSP142 Binding (recognized) of
8) Confidence 0.01 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1847697 Disease Relevance 0.08 Pain Relevance 0

General Comments

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