INT94406

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Context Info
Confidence 0.44
First Reported 1998
Last Reported 2010
Negated 6
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 3.71
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc17a5) cytoplasmic membrane-bounded vesicle (Slc17a5) plasma membrane (Slc17a5)
transmembrane transport (Slc17a5) lysosome (Slc17a5)
Anatomy Link Frequency
plasma 4
blood 1
body 1
Slc17a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 121 100.00 Very High Very High Very High
ischemia 10 98.72 Very High Very High Very High
Pain 8 96.04 Very High Very High Very High
analgesia 1 93.68 High High
aspirin 3 93.28 High High
Analgesic 9 92.76 High High
Antinociceptive 2 91.96 High High
Pain management 3 85.04 High High
isoflurane 5 83.92 Quite High
qutenza 2 83.20 Quite High
Disease Link Frequency Relevance Heat
Injury 11 99.66 Very High Very High Very High
Overdose 3 99.24 Very High Very High Very High
Cv Unclassified Under Development 16 98.72 Very High Very High Very High
Body Weight 7 98.12 Very High Very High Very High
Hepatotoxicity 19 98.00 Very High Very High Very High
Congenital Anomalies 4 96.08 Very High Very High Very High
Pain 10 96.04 Very High Very High Very High
Toxicity 70 91.16 High High
Apoptosis 12 86.04 High High
Cancer 9 82.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This compound did not change plasma AST (aspartate aminotransferase) and ALT (alanine aminotransferase) activities as well as urea and creatinine levels in mice after 72 h of exposure.
Neg (not) Regulation (change) of AST in plasma
1) Confidence 0.44 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17123507 Disease Relevance 0.33 Pain Relevance 0.52
Effects of the oil plastic extract were observed on blood elements, serum transaminases (aspartate aminotransferase, AST, and alanine aminotransferase, ALT), organ-to-body weight of the liver, kidneys and brain, and the nervous system (effects on the neuromuscular junction and analgesia, using the Rota-Rod(R) treadmill 'RRT', and the hot plate, respectively).
Regulation (Effects) of AST in body associated with body weight and analgesia
2) Confidence 0.30 Published 2001 Journal Int J Environ Health Res Section Abstract Doc Link 11260789 Disease Relevance 0.36 Pain Relevance 0.09
The effects of sodium sulphate (200 mg/kg) in combination with NAC (400 mg/kg) administered intraperitoneally 2 h post-PCM dose, on mortality rate and plasma activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were investigated in mice 24 h after receiving a single oral dose of 400 mg/kg PCM.
Spec (investigated) Regulation (effects) of AST in plasma associated with paracetamol
3) Confidence 0.29 Published 1998 Journal Inflammopharmacology Section Abstract Doc Link 17657622 Disease Relevance 0.17 Pain Relevance 0.63
The extract had no significant effect on the increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin in CCl(4) treated animals (p > 0.05).
Neg (no) Regulation (effect) of AST
4) Confidence 0.20 Published 2006 Journal Phytother Res Section Abstract Doc Link 16619345 Disease Relevance 0.18 Pain Relevance 0.66
Administration of PB did not effect AST activity at three hours, but there was a significant increase at six hours.
Neg (not) Regulation (effect) of AST
5) Confidence 0.18 Published 2002 Journal Comp. Med. Section Abstract Doc Link 11900415 Disease Relevance 0.34 Pain Relevance 0.32
Similarly, sodium sulphate (200 mg/kg) administered alone to PCM-treated mice had no effect on the high mortality rate or the elevation in plasma AST and ALT activities observed in these animals.
Neg (no) Regulation (effect) of AST in plasma associated with paracetamol
6) Confidence 0.17 Published 1998 Journal Inflammopharmacology Section Abstract Doc Link 17657622 Disease Relevance 0.14 Pain Relevance 0.70
Though, paracetamol is regarded as a safe drug at therapeutic doses; at larger or chronic doses may result in severe liver and renal injuries [30], including changes in alkaline phosphatase (ALP), AST, ALT and creatinine plasma levels [31] which could be additive to those of sunitinib [10].
Regulation (changes) of AST in plasma associated with paracetamol and injury
7) Confidence 0.15 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.82 Pain Relevance 0.59
The enzymes such as ALT, AST, ACP and ALP are responsible for the proper functioning of the liver and any damages induced in the liver due to the hyperglycemic conditions may lead to excessive leakage of these enzymes in the blood stream.
Regulation (responsible) of AST in blood
8) Confidence 0.14 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 0.48 Pain Relevance 0.03
In addition, serum chemistry tests revealed that AST and ALT activity levels did not differ significantly from the V group.
Neg (not) Regulation (differ) of AST
9) Confidence 0.11 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991689 Disease Relevance 0.21 Pain Relevance 0
Biochemical parameters like the AST and ALT were not affected, but significant increase in ALP and uric acid levels, at 2g/kg, was detected.
Neg (not) Regulation (affected) of AST
10) Confidence 0.05 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17628367 Disease Relevance 0.31 Pain Relevance 0.08
FIGURE 1.Time profile of changes in serum levels of AST (A) and ALT
(B) after hepatic ischemia/reperfusion in rats. 
Regulation (changes) of AST associated with ischemia
11) Confidence 0.01 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2596408 Disease Relevance 0.36 Pain Relevance 0.14

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