INT94423

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Context Info
Confidence 0.32
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.10
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ALAS2) small molecule metabolic process (ALAS2) biosynthetic process (ALAS2)
transferase activity, transferring acyl groups (ALAS2)
Anatomy Link Frequency
tubes 1
ALAS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 3 87.60 High High
Enkephalin 3 84.24 Quite High
Opioid 3 81.40 Quite High
opioid receptor 2 75.00 Quite High
Pain 10 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Porphyria 10 100.00 Very High Very High Very High
Sideroblastic Anemia 30 99.20 Very High Very High Very High
Disease 54 98.52 Very High Very High Very High
Cognitive Disorder 14 96.44 Very High Very High Very High
Iron Overload 48 93.28 High High
Ataxia 48 90.32 High High
Parkinson's Disease 2 81.44 Quite High
Dementia 16 79.32 Quite High
Cerebrovascular Disease 2 78.84 Quite High
Genomic Instability 4 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
sulfur cluster biogenesis; it also occurs in other diseases, such as the sideroblastic anemia caused by ALAS2 mutations, even though ALAS2 mediates the first condensation of heme biosynthesis and is not directly involved in Fe?
ALAS2 Binding (involved) of associated with porphyria, sideroblastic anemia and disease
1) Confidence 0.32 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.74 Pain Relevance 0
Recent studies have suggested that the tissue specificity is due to the special combination of ALAS2, which contains a 5?
ALAS2 Binding (combination) of
2) Confidence 0.32 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 1.05 Pain Relevance 0
Under these circumstances, I believe we have no choice but to give ANH to a patient who cannot eat."
ANH Neg (no) Binding (give) of
3) Confidence 0.03 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC1997114 Disease Relevance 0 Pain Relevance 0
The purpose of this study is to understand why Japanese physicians feel bound to provide ANH, particularly through the use of PEG tubes, to older patients with severe, irreversible cognitive impairment.
ANH Binding (bound) of in tubes associated with cognitive disorder
4) Confidence 0.03 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC1997114 Disease Relevance 0.32 Pain Relevance 0
Homologous competition curve of [3H]Ile-Delt II, a representative ligand for delta2 sites, was best fit by the one-site model (Kd = 0.82 +/- 0.07 nM).
delta2 Binding (ligand) of
5) Confidence 0.01 Published 2001 Journal Life Sci. Section Abstract Doc Link 11263677 Disease Relevance 0 Pain Relevance 0.61

General Comments

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