INT94427

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 11.15
Pain Relevance 4.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS2) oxidoreductase activity (NOS2) nucleus (NOS2)
intracellular (NOS2) cytoplasm (NOS2)
Anatomy Link Frequency
TMJ 4
lung 4
chondrocytes 2
plaques 2
platelet 2
NOS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 142 100.00 Very High Very High Very High
cytokine 109 100.00 Very High Very High Very High
Pain 33 99.96 Very High Very High Very High
Abeta 12 99.68 Very High Very High Very High
Angina 3 99.52 Very High Very High Very High
cINOD 81 98.80 Very High Very High Very High
Osteoarthritis 80 98.16 Very High Very High Very High
ischemia 8 97.76 Very High Very High Very High
corticosteroid 5 88.52 High High
aspirin 21 81.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 195 100.00 Very High Very High Very High
Infection 12 99.98 Very High Very High Very High
Pain 30 99.96 Very High Very High Very High
Adult Respiratory Distress Syndrome 40 99.92 Very High Very High Very High
Atherosclerotic Plaque 7 99.62 Very High Very High Very High
Cv General 3 Under Development 5 99.52 Very High Very High Very High
Diabetes Mellitus 10 98.24 Very High Very High Very High
Osteoarthritis 86 98.16 Very High Very High Very High
Coronary Artery Disease 3 97.76 Very High Very High Very High
Toxicity 3 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, accumulation of a marker of protein nitration nitrotyrosine, as well as the superoxide anion (O(2)(-)) levels and inducible nitric oxide synthase (iNOS), were evaluated.
Positive_regulation (accumulation) of Positive_regulation (inducible) of iNOS
1) Confidence 0.47 Published 2004 Journal Diabetes Section Abstract Doc Link 15331549 Disease Relevance 1.26 Pain Relevance 0.36
Nitrite was quantified as a measure for inducible nitric oxide synthase (iNOS) activity.
Positive_regulation (measure) of Positive_regulation (inducible) of iNOS
2) Confidence 0.42 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15076232 Disease Relevance 0.47 Pain Relevance 0.54
RESULTS: Exposure of TMJ fibrochondrocytes to rHuIL-1beta resulted in the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2), which were paralleled by NO and PGE2 production.
Positive_regulation (induction) of Positive_regulation (inducible) of iNOS in TMJ
3) Confidence 0.34 Published 2001 Journal Arthritis Rheum. Section Body Doc Link 11263775 Disease Relevance 0 Pain Relevance 0
RESULTS: Exposure of TMJ fibrochondrocytes to rHuIL-1beta resulted in the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2), which were paralleled by NO and PGE2 production.
Positive_regulation (resulted) of Positive_regulation (induction) of iNOS in TMJ
4) Confidence 0.34 Published 2001 Journal Arthritis Rheum. Section Body Doc Link 11263775 Disease Relevance 0 Pain Relevance 0
-AR stimulation and that ERK phosphorylation precedes transcriptional induction of COX-2 or iNOS.


Positive_regulation (precedes) of Positive_regulation (induction) of iNOS
5) Confidence 0.33 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.18 Pain Relevance 0.09
Recent studies show that amyloid beta (Abeta), a peptide extensively studied in Alzheimer's disease and that is cleaved from APP by beta- and gamma-secretase, and/or Abeta-like peptides are also present in human atherosclerotic plaques, in particular in activated, inducible nitric oxide synthase (iNOS) expressing perivascular macrophages that had phagocytized platelets.
Positive_regulation (activated) of Positive_regulation (inducible) of iNOS in plaques associated with atherosclerotic plaque, alzheimer's dementia, disease and abeta
6) Confidence 0.32 Published 2006 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 16724933 Disease Relevance 0.99 Pain Relevance 0.37
In vitro studies confirm that platelet phagocytosis leads to macrophage activation and suggest that platelet-derived APP is proteolytically processed to Abeta-like peptides, resulting in iNOS induction.
Positive_regulation (resulting) of Positive_regulation (induction) of iNOS in platelet associated with abeta
7) Confidence 0.26 Published 2006 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 16724933 Disease Relevance 1.01 Pain Relevance 0.47
Conversely, increased NO production after activation of iNOS by inflammatory cytokines can increase pain perception.
Positive_regulation (increase) of Positive_regulation (activation) of iNOS associated with pain, inflammation and cytokine
8) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582806 Disease Relevance 1.87 Pain Relevance 1.31
Our results suggest that the activation of PKA is also required for the ET-1-induced upregulation of iNOS and for subsequent production of NO by human OA chondrocytes.
Positive_regulation (required) of Positive_regulation (upregulation) of iNOS in chondrocytes associated with osteoarthritis
9) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.27 Pain Relevance 0.14
OA may also promote ALI by increasing the ratio between angiotensin-converting enzymes I and II [47], upregulating inducible nitric-oxide synthase (iNOS), and inhibiting alveolar epithelial Na,K-ATPase activity [48].
Positive_regulation (upregulating) of Positive_regulation (increasing) of iNOS associated with adult respiratory distress syndrome
10) Confidence 0.17 Published 2008 Journal Crit Care Section Body Doc Link PMC2646309 Disease Relevance 0.98 Pain Relevance 0.16
Increased inducible nitric oxide synthase (iNOS) and resultant NO levels have been isolated in lung tissue as a result of inhalation injury (Enkhbaatar et al 2003).
Positive_regulation (Increased) of Positive_regulation (inducible) of iNOS in lung associated with injury
11) Confidence 0.13 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761179 Disease Relevance 0.88 Pain Relevance 0.14
Increased inducible nitric oxide synthase (iNOS) and resultant NO levels have been isolated in lung tissue as a result of inhalation injury (Enkhbaatar et al 2003).
Positive_regulation (inducible) of Positive_regulation (Increased) of iNOS in lung associated with injury
12) Confidence 0.13 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761179 Disease Relevance 0.88 Pain Relevance 0.14
FIV infection up-regulated inducible NO synthase (iNOS), STAT-1, and TNF-alpha mRNA levels in DRG cultures.
Positive_regulation (up-regulated) of Positive_regulation (up-regulated) of inducible NO synthase in DRG associated with infection
13) Confidence 0.09 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.44 Pain Relevance 0.11
-cells are in particular the generation of nitric oxide via induction of the inducible nitric oxide synthase (iNOS) and production of reactive oxygen species.
Positive_regulation (induction) of Positive_regulation (induction) of iNOS
14) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2838227 Disease Relevance 0.94 Pain Relevance 0.48

General Comments

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