INT94428

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 20
Total Number 24
Disease Relevance 11.61
Pain Relevance 5.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS2) oxidoreductase activity (NOS2) nucleus (NOS2)
intracellular (NOS2) cytoplasm (NOS2)
Anatomy Link Frequency
macrophage 2
chondrocytes 2
glial cells 2
Cartilage 2
THP-1 2
NOS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 109 99.90 Very High Very High Very High
Inflammation 306 99.74 Very High Very High Very High
opiate 4 99.58 Very High Very High Very High
Locus ceruleus 5 99.28 Very High Very High Very High
COX2 4 98.86 Very High Very High Very High
cOX1 2 98.86 Very High Very High Very High
ischemia 7 98.28 Very High Very High Very High
Inflammatory mediators 14 94.80 High High
Analgesic 6 93.68 High High
Osteoarthritis 144 93.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 351 99.74 Very High Very High Very High
Ulcers 4 99.64 Very High Very High Very High
Peptic Ulcer 2 99.14 Very High Very High Very High
Diabetes Mellitus 17 98.84 Very High Very High Very High
Cv Unclassified Under Development 2 98.28 Very High Very High Very High
Cognitive Disorder 4 95.96 Very High Very High Very High
Death 23 95.76 Very High Very High Very High
Osteoarthritis 149 93.28 High High
Headache 1 93.12 High High
Neurasthenia 1 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of BV-2 cells with GLNVA diminished LPS-induced nitric oxide production, overexpression of inducible nitric-oxide synthase (iNOS), and gp91(phox) and intracellular reactive oxygen species (iROS).
Negative_regulation (diminished) of Gene_expression (production) of iNOS
1) Confidence 0.47 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.94 Pain Relevance 0.20
RESULTS: Preincubation of the tissue with morphine, anandamide or estrogen prior to, but not after, the addition of LPS + IFN-gamma, blocked iNOS expression.
Negative_regulation (blocked) of Gene_expression (expression) of iNOS
2) Confidence 0.37 Published 2000 Journal Acta Pharmacol. Sin. Section Body Doc Link 11324436 Disease Relevance 0 Pain Relevance 0
However, in the brain of opiate addicts, NADPHd and iNOS expression was detected in noradrenergic LC cells, correlating with an increase in iNOS and TNF-alpha expression in glial cells as revealed by immunohistochemical and Western blot analyses.
Negative_regulation (detected) of Gene_expression (expression) of iNOS in glial cells associated with locus ceruleus and opiate
3) Confidence 0.37 Published 2009 Journal J. Chem. Neuroanat. Section Abstract Doc Link 19038328 Disease Relevance 0.35 Pain Relevance 0.63
Diabetes is associated with increased myocardial tissue levels of iNOS, O(2)(-), and nitrotyrosine and reduced expression of myocardial angiogenesis factors during ischemia.
Negative_regulation (reduced) of Gene_expression (expression) of iNOS associated with diabetes mellitus and ischemia
4) Confidence 0.35 Published 2004 Journal Diabetes Section Abstract Doc Link 15331549 Disease Relevance 1.08 Pain Relevance 0.30
GLNVA also suppressed accumulation of iROS and up-regulated heme oxygenase-1 expression. 6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.
Negative_regulation (reduced) of Gene_expression (overexpression) of iNOS
5) Confidence 0.34 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.64 Pain Relevance 0.16
Pretreatment of BV-2 cells with GLNVA diminished LPS-induced nitric oxide production, overexpression of inducible nitric-oxide synthase (iNOS), and gp91(phox) and intracellular reactive oxygen species (iROS).
Negative_regulation (diminished) of Gene_expression (production) of inducible nitric-oxide synthase
6) Confidence 0.34 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.93 Pain Relevance 0.20
Armillariella mellea shows anti-inflammatory activity by inhibiting the expression of NO, iNOS, COX-2 and cytokines in THP-1 cells.
Negative_regulation (inhibiting) of Gene_expression (expression) of iNOS in THP-1 associated with inflammation, cox1 and cytokine
7) Confidence 0.30 Published 2007 Journal Am. J. Chin. Med. Section Title Doc Link 17597509 Disease Relevance 0.60 Pain Relevance 0.61
The ET-1-induced iNOS protein expression was completely suppressed by SB202190 and LY83583, and was partially suppressed by Wortmannin and KT5720.
Negative_regulation (suppressed) of Gene_expression (expression) of iNOS
8) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0
Concomitant application of CTS abrogated the catabolic effects of IL-1beta on TMJ chondrocytes by inhibiting iNOS, COX-2, and MMP-1 mRNA production and NO, PGE2, and MMP-1 synthesis.
Negative_regulation (inhibiting) of Gene_expression (synthesis) of iNOS in chondrocytes
9) Confidence 0.29 Published 2001 Journal Arthritis Rheum. Section Body Doc Link 11263775 Disease Relevance 0 Pain Relevance 0
Moreover, preincubation of UROtsa cells with the selective PKA inhibitors H-89 or Rp-cAMPs did not diminish this isoproterenol mediated phosphorylation of ERK or production of iNOS and COX-2.


Neg (not) Negative_regulation (diminish) of Gene_expression (production) of iNOS
10) Confidence 0.28 Published 2005 Journal Cell Commun Signal Section Abstract Doc Link PMC1198236 Disease Relevance 0.34 Pain Relevance 0.31
Additional study by RT-PCR demonstrated that the extract of Crinum asiaticum significantly suppressed the expression of the iNOS gene.
Negative_regulation (suppressed) of Gene_expression (expression) of iNOS
11) Confidence 0.26 Published 2008 Journal J Cosmet Sci Section Abstract Doc Link 18841306 Disease Relevance 0.47 Pain Relevance 0.17
Interestingly in healing gastric ulcers we confirmed that sangre de grado therapy reduces the expression of inducible nitric oxide synthase (iNOS) in the ulcer bed, along with IL-1?
Negative_regulation (reduces) of Gene_expression (expression) of iNOS associated with ulcers and peptic ulcer
12) Confidence 0.24 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1971260 Disease Relevance 0.31 Pain Relevance 0.07
Moreover, the guanylate cyclase inhibitor LY83583 reduced the NO production as significant differences were found when compared with either the ET-1 stimulation (P < 0.05) or with the control (P < 0.05), and this inhibitor also decreased both the endogenous and ET-1-induced iNOS level (Fig. 2d).
Negative_regulation (decreased) of Gene_expression (level) of iNOS
13) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0
Marzocco [34] demonstrated that yuccaols inhibit inducible nitric oxide synthase (iNOS) expression (Fig. 3).
Negative_regulation (inhibit) of Gene_expression (expression) of iNOS
14) Confidence 0.20 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1440857 Disease Relevance 1.14 Pain Relevance 0.54
He also developed the collaboration with SP, and collectively they demonstrated the role of yucca phenolics as inhibitors of NFkB and iNOS production.



Negative_regulation (inhibitors) of Gene_expression (production) of iNOS
15) Confidence 0.20 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1440857 Disease Relevance 0.45 Pain Relevance 0.10
Marzocco [34] demonstrated that yuccaols inhibit inducible nitric oxide synthase (iNOS) expression (Fig. 3).
Negative_regulation (inhibit) of Gene_expression (expression) of inducible nitric oxide synthase
16) Confidence 0.20 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1440857 Disease Relevance 1.14 Pain Relevance 0.54
Cartilage samples were used to determine expression of iNOS and COX-2 protein.
Spec (determine) Negative_regulation (determine) of Spec (determine) Gene_expression (expression) of iNOS in Cartilage
17) Confidence 0.18 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.32 Pain Relevance 0.16
Our study revealed that paeoniflorin decreased the expression of COX-2 and iNOS in HDMECs.
Negative_regulation (decreased) of Gene_expression (expression) of iNOS
18) Confidence 0.18 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3021874 Disease Relevance 0.75 Pain Relevance 0.54
Western blot analyses revealed that the expression of COX-2 and iNOS was increased by LPS stimulation in HDMECs whereas the treatment with paeoniflorin resulted in a decrease in COX-2 and iNOS expression (Figure 3).


Negative_regulation (decrease) of Gene_expression (expression) of iNOS
19) Confidence 0.13 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3021874 Disease Relevance 0.28 Pain Relevance 0.17
Next, we examined whether paeoniflorin could inhibit the production of COX-2 and iNOS.
Negative_regulation (inhibit) of Gene_expression (production) of iNOS
20) Confidence 0.13 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3021874 Disease Relevance 0.27 Pain Relevance 0.20

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