INT94429

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.05
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2)
Anatomy Link Frequency
chondrocytes 2
cartilage 1
TIMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 162 96.56 Very High Very High Very High
metalloproteinase 62 91.20 High High
Inflammatory mediators 6 90.48 High High
cytokine 3 73.60 Quite High
Snapping jaw 1 50.00 Quite Low
Inflammation 19 33.84 Quite Low
COX2 1 10.00 Low Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Dysuria 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overweight 39 100.00 Very High Very High Very High
Obesity 312 99.04 Very High Very High Very High
Renal Cancer 4 98.96 Very High Very High Very High
Cancer 36 98.92 Very High Very High Very High
Aggression 2 98.64 Very High Very High Very High
Osteoarthritis 162 96.56 Very High Very High Very High
INFLAMMATION 22 90.48 High High
Disease 5 74.80 Quite High
Bladder Cancer 29 73.84 Quite High
Transitional Cell Carcinoma 26 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kugler et al. [38] stated for renal cell carcinoma (RCC) that the balance of MMP2- and MMP9- to TIMP1- and TIMP2-mRNA expression is a prognostic factor of tumour aggressiveness.
Transcription (expression) of TIMP2 associated with cancer, aggression and renal cancer
1) Confidence 0.61 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.93 Pain Relevance 0.22
Similarly, leptin did not induce any change in the mRNA level of TIMP-2 in cells isolated from obese patients (Figure 2).
Transcription (level) of TIMP-2 associated with obesity
2) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.90 Pain Relevance 0.08
The gene encoding TIMP-2 was induced in chondrocytes obtained from normal or overweight patients while mRNA level of MMP-13 or COX-2 was increased in leptin-treated chondrocytes collected from obese OA patients.
Transcription (level) of TIMP-2 in chondrocytes associated with obesity, osteoarthritis and overweight
3) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.32 Pain Relevance 0.12
By contrast, mRNA levels for TIMP-2 was markedly increased in leptin-treated chondrocytes compared with control cells.
Transcription (levels) of TIMP-2 in chondrocytes
4) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.90 Pain Relevance 0.26
CTS also counteracted cartilage degradation by augmenting expression of mRNA for tissue inhibitor of metalloproteinases 2 that is inhibited by rHuIL-1beta.
Transcription (expression) of metalloproteinases 2 in cartilage
5) Confidence 0.08 Published 2001 Journal Arthritis Rheum. Section Body Doc Link 11263775 Disease Relevance 0 Pain Relevance 0

General Comments

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