INT94430

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Context Info
Confidence 0.24
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.25
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2)
Anatomy Link Frequency
chondrocytes 4
cartilage 2
TIMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 108 97.88 Very High Very High Very High
Inflammatory mediators 4 81.08 Quite High
cytokine 2 73.60 Quite High
Snapping jaw 1 50.00 Quite Low
Inflammation 12 33.84 Quite Low
COX2 1 10.00 Low Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overweight 26 100.00 Very High Very High Very High
Obesity 208 98.12 Very High Very High Very High
Osteoarthritis 108 97.88 Very High Very High Very High
INFLAMMATION 14 80.68 Quite High
Temporomandibular Joint Syndrome 1 50.00 Quite Low
Sprains And Strains 1 50.00 Quite Low
Arthritis 2 33.84 Quite Low
Body Weight 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gene encoding TIMP-2 was induced in chondrocytes obtained from normal or overweight patients while mRNA level of MMP-13 or COX-2 was increased in leptin-treated chondrocytes collected from obese OA patients.
Positive_regulation (increased) of Transcription (level) of TIMP-2 in chondrocytes associated with obesity, osteoarthritis and overweight
1) Confidence 0.24 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.34 Pain Relevance 0.12
By contrast, mRNA levels for TIMP-2 was markedly increased in leptin-treated chondrocytes compared with control cells.
Positive_regulation (increased) of Transcription (levels) of TIMP-2 in chondrocytes
2) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.92 Pain Relevance 0.26
CTS also counteracted cartilage degradation by augmenting expression of mRNA for tissue inhibitor of metalloproteinases 2 that is inhibited by rHuIL-1beta.
Positive_regulation (augmenting) of Transcription (expression) of metalloproteinases 2 in cartilage
3) Confidence 0.06 Published 2001 Journal Arthritis Rheum. Section Body Doc Link 11263775 Disease Relevance 0 Pain Relevance 0

General Comments

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