INT94437

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 16.04
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (OLR1) extracellular region (OLR1) cell adhesion (OLR1)
plasma membrane (OLR1)
Anatomy Link Frequency
plasma 8
coronary artery 6
platelets 4
OLR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 88 99.98 Very High Very High Very High
Inflammation 200 96.84 Very High Very High Very High
Inflammatory response 5 96.84 Very High Very High Very High
cytokine 31 95.36 Very High Very High Very High
Angina 38 93.12 High High
methotrexate 36 90.68 High High
abatacept 1 88.80 High High
anakinra 1 86.56 High High
Etanercept 1 85.00 Quite High
Adalimumab 1 83.36 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 89 99.98 Very High Very High Very High
Hyperlipidemia 15 99.96 Very High Very High Very High
Autoimmune Disease 10 99.76 Very High Very High Very High
Disease 155 99.68 Very High Very High Very High
Congenital Anomalies 22 99.66 Very High Very High Very High
Rheumatic Diseases 3 99.64 Very High Very High Very High
Atherosclerosis 191 99.60 Very High Very High Very High
Hypoxia 14 99.44 Very High Very High Very High
Acute Myeloid Leukemia 25 99.40 Very High Very High Very High
Acute Coronary Syndrome 85 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation-dependent surface expression of LOX-1 in human platelets.
Positive_regulation (Activation) of Gene_expression (expression) of LOX-1 in platelets
1) Confidence 0.70 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 11263985 Disease Relevance 0.29 Pain Relevance 0.15
In fact, just to calculate COX and LOX products’ global effect, we have to consider more than 25 active substances, each with two to five different actions, having different cellular or extracellular tissue and organ targets, depending on their different baseline and under-stimulus production rate (Figure 1) (Bertolini et al 2002).
Positive_regulation (calculate) of Gene_expression (products) of LOX
2) Confidence 0.49 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684079 Disease Relevance 0.49 Pain Relevance 0.50
Activation-dependent surface expression of LOX-1 in human platelets.
Positive_regulation (dependent) of Gene_expression (expression) of LOX-1 in platelets
3) Confidence 0.47 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 11263985 Disease Relevance 0.29 Pain Relevance 0.15
Indeed, the work from Piarulli et al. demonstrated that plasma oxLDL levels were increased just among the longstanding diabetes patients.
Positive_regulation (increased) of Gene_expression (levels) of oxLDL in plasma associated with diabetes mellitus
4) Confidence 0.39 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 1.01 Pain Relevance 0
A strong correlation between endothelial function abnormalities and high plasma levels of oxLDL was also demonstrated with regard to the coronary and brachial arteries.26,27 OxLDL plasma levels were also independent predictors of coronary artery disease28 and were even stronger predictors than LDL and total cholesterol blood levels.29
Positive_regulation (demonstrated) of Gene_expression (levels) of oxLDL in plasma associated with congenital anomalies and disorder of lipid metabolism
5) Confidence 0.39 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 0.58 Pain Relevance 0
In subjects with familial hyperlipidemia, elevated blood oxLDL and LDL-cholesterol levels were associated with increased carotid intimal-media thickness.23 In two other studies, elevated plasma oxLDL levels were associated with increased carotid intimal-media thickness in asymptomatic subjects whose relatives had familial hypercholesterolemia and also in asymptomatic middle-aged males.24,25
Positive_regulation (elevated) of Gene_expression (levels) of oxLDL in plasma associated with hyperlipoproteinemia type ii and hyperlipidemia
6) Confidence 0.34 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 0.68 Pain Relevance 0
Experimental data showed that this accumulation may lead to cell proliferation, hypertrophy, apoptosis, or necrosis, depending on the amount and duration of the exposure of the cells to oxLDL.15,16 Moreover, this accumulation may also inactivate nitric oxide17 and sensitize the contractile apparatus of the vessel wall, thus inducing vasoconstriction.18
Positive_regulation (inactivate) of Gene_expression (exposure) of oxLDL associated with necrosis, hypertrophy, increased venous pressure under development and apoptosis
7) Confidence 0.34 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 1.06 Pain Relevance 0.07
A strong correlation between endothelial function abnormalities and high plasma levels of oxLDL was also demonstrated with regard to the coronary and brachial arteries.26,27 OxLDL plasma levels were also independent predictors of coronary artery disease28 and were even stronger predictors than LDL and total cholesterol blood levels.29
Positive_regulation (demonstrated) of Gene_expression (levels) of OxLDL in plasma associated with congenital anomalies and disorder of lipid metabolism
8) Confidence 0.34 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 0.63 Pain Relevance 0
In the preliminary investigation we found a descensive oxLDL- lgG and an elevated oxLDL-lgM serum levels for the adult AML.
Positive_regulation (elevated) of Gene_expression (levels) of oxLDL-lgM associated with acute myeloid leukemia
9) Confidence 0.11 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2834680 Disease Relevance 0.50 Pain Relevance 0
Circulating levels of Ox-LDL have been associated with the presence of coronary artery disease in patients undergoing elective angiography; similarly elevated Ox-LDL levels are significantly higher in patients with ACS, finally, some but not all prospective studies have shown higher Ox-LDL levels in patients subsequent development of cardiac death, non-fatal MI, and unstable angina.
Positive_regulation (elevated) of Gene_expression (levels) of Ox-LDL in coronary artery associated with acute coronary syndrome, angina, coronary artery disease, myocardial infarction and death
10) Confidence 0.11 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716784 Disease Relevance 1.54 Pain Relevance 0.24
Circulating levels of Ox-LDL have been associated with the presence of coronary artery disease in patients undergoing elective angiography; similarly elevated Ox-LDL levels are significantly higher in patients with ACS, finally, some but not all prospective studies have shown higher Ox-LDL levels in patients subsequent development of cardiac death, non-fatal MI, and unstable angina.
Positive_regulation (Circulating) of Gene_expression (levels) of Ox-LDL in coronary artery associated with acute coronary syndrome, angina, coronary artery disease, myocardial infarction and death
11) Confidence 0.11 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716784 Disease Relevance 1.69 Pain Relevance 0.24
Circulating levels of Ox-LDL have been associated with the presence of coronary artery disease in patients undergoing elective angiography; similarly elevated Ox-LDL levels are significantly higher in patients with ACS, finally, some but not all prospective studies have shown higher Ox-LDL levels in patients subsequent development of cardiac death, non-fatal MI, and unstable angina.
Positive_regulation (higher) of Gene_expression (levels) of Ox-LDL in coronary artery associated with acute coronary syndrome, angina, coronary artery disease, myocardial infarction and death
12) Confidence 0.11 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716784 Disease Relevance 1.44 Pain Relevance 0.22
Oxidized-LDL (Ox-LDL) is generated during lipid peroxidation, resulting in generation of reactive species that modify the lipid components of LDL.
Positive_regulation (generated) of Gene_expression (generated) of Ox-LDL
13) Confidence 0.10 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716784 Disease Relevance 1.80 Pain Relevance 0.12
A vegan diet in RA induced decreased LDL and oxLDL levels and raised levels of natural antibodies of IgA and IgM subclasses to PC.
Positive_regulation (induced) of Gene_expression (levels) of oxLDL associated with rheumatoid arthritis
14) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453753 Disease Relevance 0.80 Pain Relevance 0.20
Also of interest is that another marker of many diseases, homocysteine, enhances endothelial LOX-1 expression [38].
Positive_regulation (enhances) of Gene_expression (expression) of LOX-1 associated with disease
15) Confidence 0.06 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.17 Pain Relevance 0.05
Using antibodies that recognized the oxidative epitopes of phospholipids moiety of LDL (oxPL), diet-induced atherosclerosis is associated with increased levels of oxLDL and increased levels of total oxPL as well as oxPL/apoB [35].
Positive_regulation (increased) of Gene_expression (levels) of oxLDL associated with atherosclerosis
16) Confidence 0.04 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3022166 Disease Relevance 0.61 Pain Relevance 0
The levels of IL-6 and its soluble receptor (sIL-6ra) are elevated in many rheumatic diseases.7,8 and the overproduction of IL-6 is thought to play a role in the pathogenesis of RA.9 Encouraging data from several clinical trials have led to the approval of tocilizumab in Europe in combination with methotrexate (MTX) for the treatment of adult patients with moderate to severe active RA who has inadequate response from previous treatment with one or more disease-modifying antirheumatic drugs (DMARDs) or tumor necrosis factor inhibitors (TNF).
Positive_regulation (elevated) of Gene_expression (levels) of soluble receptor associated with necrosis, cancer, rheumatoid arthritis, disease, methotrexate and rheumatic diseases
17) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857613 Disease Relevance 1.48 Pain Relevance 0.87

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