INT94438

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 86
Total Number 90
Disease Relevance 80.38
Pain Relevance 11.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (OLR1) extracellular region (OLR1) cell adhesion (OLR1)
plasma membrane (OLR1)
Anatomy Link Frequency
plasma 16
esophagus 6
coronary artery 4
plaques 4
synovial fluids 2
OLR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 268 99.92 Very High Very High Very High
rheumatoid arthritis 644 99.46 Very High Very High Very High
Inflammation 721 99.42 Very High Very High Very High
cINOD 70 98.60 Very High Very High Very High
Angina 116 98.36 Very High Very High Very High
Inflammatory response 24 96.00 Very High Very High Very High
cytokine 97 95.36 Very High Very High Very High
methotrexate 63 89.76 High High
Pain 47 89.32 High High
abatacept 1 88.80 High High
Disease Link Frequency Relevance Heat
Adhesions 69 100.00 Very High Very High Very High
Atherosclerosis 998 99.92 Very High Very High Very High
Myocardial Infarction 222 99.84 Very High Very High Very High
Atherosclerotic Plaque 125 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 88 99.84 Very High Very High Very High
Autoimmune Disease 33 99.76 Very High Very High Very High
Congenital Anomalies 66 99.66 Very High Very High Very High
Hyperlipidemia 52 99.66 Very High Very High Very High
Diabetes Mellitus 152 99.56 Very High Very High Very High
Disorder Of Lipid Metabolism 1104 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation-dependent surface expression of LOX-1 in human platelets.
Gene_expression (expression) of LOX-1 in platelets
1) Confidence 0.78 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 11263985 Disease Relevance 0.29 Pain Relevance 0.15
Plasma ox-LDL levels in AMI patients were significantly higher than in UAP patients (P<.0001), SAP patients (P<.0001), or controls (P<.0001).
Gene_expression (levels) of ox-LDL in Plasma associated with angina and myocardial infarction
2) Confidence 0.68 Published 2002 Journal J. Diabetes Complicat. Section Abstract Doc Link 11872369 Disease Relevance 2.10 Pain Relevance 0.93
Flow cytometric analyses revealed that LOX-1 was exposed on the surface of platelets in an activation-dependent manner.
Gene_expression (exposed) of LOX-1 in platelets
3) Confidence 0.67 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11263985 Disease Relevance 0.32 Pain Relevance 0.16
From this point of view, the new class of the LOX/COX inhibitors present several beneficial and promising therapeutic effects that could be very important in the elderly (Skelly and Hawkey 2003), and mainly:
Gene_expression (/) of LOX
4) Confidence 0.65 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684079 Disease Relevance 0.55 Pain Relevance 0.47
From this point of view, the new class of the LOX/COX inhibitors present several beneficial and promising therapeutic effects that could be very important in the elderly (Skelly and Hawkey 2003), and mainly:
Gene_expression (class) of LOX
5) Confidence 0.65 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684079 Disease Relevance 0.55 Pain Relevance 0.48
In fact, just to calculate COX and LOX products’ global effect, we have to consider more than 25 active substances, each with two to five different actions, having different cellular or extracellular tissue and organ targets, depending on their different baseline and under-stimulus production rate (Figure 1) (Bertolini et al 2002).
Gene_expression (products) of LOX
6) Confidence 0.65 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684079 Disease Relevance 0.49 Pain Relevance 0.50
Determination of serum ADP, oxLDL, oxLDL-ab, oxLDL-lgG, and oxLDL-lgM
Gene_expression (lgG) of oxLDL
7) Confidence 0.64 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 0.74 Pain Relevance 0
The main finding of the present study is the descending trends of plasma oxLDL, oxLDL-ab, and oxLDL-lgG levels and the elevated trends of plasma oxLDL-lgM levels along with the series of histological spectrum of disease from normal to early invasive squamous cell carcinoma of the esophagus.
Gene_expression (levels) of oxLDL in esophagus associated with basal and squamous cell skin cancer and disease
8) Confidence 0.64 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 0.83 Pain Relevance 0
Determination of serum ADP, oxLDL, oxLDL-ab, oxLDL-lgG, and oxLDL-lgM
Gene_expression (lgG) of oxLDL
9) Confidence 0.64 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 0.75 Pain Relevance 0
The main finding of the present study is the descending trends of plasma oxLDL, oxLDL-ab, and oxLDL-lgG levels and the elevated trends of plasma oxLDL-lgM levels along with the series of histological spectrum of disease from normal to early invasive squamous cell carcinoma of the esophagus.
Gene_expression (levels) of oxLDL in esophagus associated with basal and squamous cell skin cancer and disease
10) Confidence 0.64 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 0.83 Pain Relevance 0
The main finding of the present study is the descending trends of plasma oxLDL, oxLDL-ab, and oxLDL-lgG levels and the elevated trends of plasma oxLDL-lgM levels along with the series of histological spectrum of disease from normal to early invasive squamous cell carcinoma of the esophagus.
Gene_expression (levels) of oxLDL in esophagus associated with basal and squamous cell skin cancer and disease
11) Confidence 0.64 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 0.82 Pain Relevance 0
The significance of lipid and its novel constituents such as adiponectin, immunoglobulin G and M types of autoantibodies to oxidized low-density lipoprotein (oxLDL-lgG and oxLDL-lgM) has been previously established in relation to cardiovascular disease [14,15].
Gene_expression (lgG) of oxLDL associated with cardiovascular disease
12) Confidence 0.64 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 0.63 Pain Relevance 0
The significance of lipid and its novel constituents such as adiponectin, immunoglobulin G and M types of autoantibodies to oxidized low-density lipoprotein (oxLDL-lgG and oxLDL-lgM) has been previously established in relation to cardiovascular disease [14,15].
Gene_expression (lgG) of oxLDL associated with cardiovascular disease
13) Confidence 0.64 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 0.63 Pain Relevance 0
The main finding of the present study is the descending trends of plasma oxLDL, oxLDL-ab, and oxLDL-lgG levels and the elevated trends of plasma oxLDL-lgM levels along with the series of histological spectrum of disease from normal to early invasive squamous cell carcinoma of the esophagus.
Gene_expression (levels) of oxLDL in esophagus associated with basal and squamous cell skin cancer and disease
14) Confidence 0.64 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 0.83 Pain Relevance 0
This increase was related to the expression of lectin-like ox-LDL receptor-1 on monocytes.
Gene_expression (expression) of lectin-like ox-LDL receptor-1 in monocytes
15) Confidence 0.59 Published 2005 Journal J. Am. Coll. Cardiol. Section Body Doc Link 16139128 Disease Relevance 0.12 Pain Relevance 0
Plasma ox-LDL levels were measured in 210 patients (AMI: 70, UAP: 70, SAP: 70), and in 55 control subjects.
Gene_expression (levels) of ox-LDL in Plasma associated with angina and myocardial infarction
16) Confidence 0.59 Published 2002 Journal J. Diabetes Complicat. Section Abstract Doc Link 11872369 Disease Relevance 2.09 Pain Relevance 0.92
Cyclooxygenase (COX)-2 produces procarcinogenic prostaglandin E2, whereas 15-lipoxygenase (LOX)-1 produces PPAR?
Gene_expression (produces) of LOX
17) Confidence 0.58 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2422868 Disease Relevance 0.79 Pain Relevance 0
Comparison of serum levels of ADP, oxLDL, oxLDL-ab, oxLDL-lgG, and oxLDL-lgM among the four groups
Gene_expression (levels) of oxLDL
18) Confidence 0.57 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 0.52 Pain Relevance 0
The foundation of these samples pressed us to establish the relationship of the serum levels of lipid-related constituents to these different lesions and carcinoma of the esophagus, especially the levels of oxLDL-lgG or/and oxLDL-lgM to the different stages in the progression of ESSC.


Gene_expression (levels) of oxLDL in esophagus associated with basal and squamous cell skin cancer and carcinoma
19) Confidence 0.57 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 1.71 Pain Relevance 0.07
In the present study, we found that the descending levels of oxLDL and oxLDL-ab may negatively related to the different stages of the development of esophageal cancer while the elevated levels of oxLDL-lgM has a positive potence, which is contrary in the case of their relations to cardiovascular and cerebrovascular diseases revealed in previous literature.
Gene_expression (levels) of oxLDL associated with disease and esophageal cancer
20) Confidence 0.57 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 0.51 Pain Relevance 0

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